ARYA Atherosclerosis Journal

COMPARISON OF SOYMILK AND PROBIOTIC SOYMILK EFFECTS ON SERUM HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN DIABETIC WISTAR RATS

Document Type : Original Article(s)

Authors

Mina Babashahi 1
Maryam Mirlohi 2
Reza Ghiasvand 3
Leila Azadbakht 4

1 Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2 Food Security Research Center AND Department of Food Science and Technology, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

3 Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

4 Food Security Research Center AND Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract
BACKGROUND: Soy milk (SM) and its fermented products are identified as rich sources of bioactive compounds helping to manage and to reduce the risk of chronic disease. This study aimed to compare the effects of SM and probiotic SM (PSM) consumption on serum low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) in diabetic Wistar rats.
METHODS: Probiotic SM was prepared by fermentation of the plain SM with a native strain of Lactobacillus plantarum. 20 streptozotocin-nicotinamide-induced diabetic Wistar rats were divided into two groups based on the type of administered SM (SM group and PSM group). The animals were fed with 1 ml/day of either soy or PSM for 21 days. The serum lipoprotein levels were analyzed at baseline and the end of the intervention period.
RESULTS: HDL-C increased significantly in PSM group. Furthermore, this group showed more percent of change in increased HDL-C in compression with SM group (P < 0.050). Regarding LDL-C level, rats fed with SM was not significantly different from the PSM group (P < 0.050); though, this biomarker was reduced in both group.
CONCLUSION: Probiotic SM could modulate blood lipoprotein levels. Thus, it may be considered in managing diabetes complications and atherosclerotic risks.
 

Keywords

Lactobacillus
Probiotic
Low Density Lipoprotein Cholesterol
High Density Lipoprotein Cholesterol
Soy Milk
ARYA Atherosclerosis Journal
Volume 11, SUPPL 1
Winter 2015
Pages 88-93

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