ARYA Atherosclerosis Journal

The Value of NOX3 Gene Polymorphism (Rs3749930) To Predict Lower Overall Survival of Patients with Abdominal Aortic Aneurysm Undergoing Endovascular Aneurysm Repairing Surgery

Document Type : Original Article

Authors

Hidayet Demir
Mehmet Altuğ Tunçer
Mehrdad Sheikhvatan
Sumaia M. Abuqalben

Cardiovascular Surgery Research Center, Istanbul Okan University, Istanbul, Turkey

https://doi.org/10.48305/arya.2026.45423.3072
Abstract
BACKGROUND: Due to the relationship between changes in NOX3 gene expression and production of reactive oxygen species (ROS) activity, as well as the correlation between ROS activity and the occurrence of abdominal aortic aneurysm (AAA), this study proposed the hypothesis for the first time that the occurrence of rs3749930 polymorphism in the NOX3 gene may predict adverse outcomes in patients with AAA undergoing endovascular aneurysm repairing (EVAR) surgery.
METHODS: The study participants included 1092 patients aged higher than 18 years suffered from AAA and candidate for EVAR. The Kompetitive Allele Specific polymerase chain reaction (KASP) method was used to genotyping the rs3749930 polymorphism in the NOX3 gene. The mean follow-up time of the patients was 6.6 years to assess post-procedural long-term outcome.
RESULTS: The prevalence of G and T alleles in the study population was found to be 86.3% and 13.7% respectively. The prevalence of G and T alleles in died patients 93.0% and 7.0% and in survived patients was 83.2% and 16.8% respectively indicating a significant difference (P = 0.012). The 5-year overall survival in patients with the GG variant of rs3749930 polymorphism 58.6% and in those with GT+TT genotype was 73.4%. According to Cox proportional hazard modeling, the presence of GG variant along with older age, female gender, history of renal dysfunction, and higher aneurysm diameter were the correlates of long-term death.
CONCLUSION: Tracking the presence of G dominant allele of NOX3 gene polymorphism (rs3749930) can predict lower overall survival following EVAR surgery.

Keywords

Arterial aneurysm
Endovascular surgery
Nadph oxidase
Gene
Reactive oxygen species
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ARYA Atherosclerosis Journal
Volume 22, Issue 4
July and August 2026
Pages 11-20

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