ARYA Atherosclerosis Journal

Hypertension and 10-year risk of coronary artery diseases in adult population: Yazd healthy heart project

Document Type : Original Article

Authors

Mohammadtaghi Sarebanhassanabadi 1
Mahdieh Mousavirad 1, 2
Lida Hosseini 3
Pedro Marques-Vidal 4
Alexander Kraemer 5
Seyedeh Mahdieh Namayandeh 1, 6
Hamideh Mihanpour 7, 8
Sima Mozafari 1

1 Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Department of Physical Medicine & Rehabilitation, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Department of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran

4 Department of Internal Medicine, BH10-642, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland

5 Department of Health Sciences, Bielefeld University, Bielefeld, Germany

6 Clinical Research Development Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

7 Department of Occupational Health Engineering, Genetic and Environmental Adventures Research Center, School of Abarkouh Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

8 Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

10.48305/arya.2025.45949.3127
Abstract
BACKGROUND: The incidence of coronary artery disease (CAD) is influenced by several risk factors, including hypertension. Although the association between hypertension and CAD has been investigated in Western countries, limited research has been conducted in Asia and the Middle East. We investigated the association between hypertension and the 10‑year risk of CAD in the adult population.
METHODS: In this cohort study, 2,000 participants aged 20 to 74 years in the Yazd Healthy Heart Project were enrolled in 2005–2006 and followed up to 2015–2016. Participants with a history of CAD were excluded. At baseline, data on demographic characteristics, anthropometric measurements, biochemical blood tests, and lifestyle factors were collected. The association between hypertension and approximately 10‑year CAD risk was assessed using the Cox regression model.
RESULTS: The baseline prevalence of hypertension among adults was 36.1%. During the ten‑year follow‑up, CAD incidence was 16.8% in men, 12.0% in women, and 14.5% in the total population. After adjusting for potential confounders, hypertension increased the risk of CAD in men (HR = 1.64; 95% CI: 1.09–2.46), women (HR = 2.16; 95% CI: 1.15–4.05), and the whole sample (HR = 1.73; 95% CI: 1.23–2.43). This association was similar in men and women (p for interaction ≥0.05).
CONCLUSION: This study demonstrated a significant association between hypertension and CAD risk, highlighting the need for targeted interventions in populations with hypertension to reduce CAD risk.

Keywords

Coronary Artery Disease
Hypertension
Incidence
Risk Factors
Cohort Studies
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ARYA Atherosclerosis Journal
Volume 22, Issue 2
March and April 2026
Pages 26-34

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