ARYA Atherosclerosis Journal

Hypertriglyceridemic waist phenotype and 10-year incidence of hypertension: Yazd healthy heart cohort study

Document Type : Original Article

Authors

Mohammadtaghi Sarebanhassanabadi 1
Mahnaz Eider 1
Hamideh Mihanpour 2
Pedro Marques-Vidal 3
Seyed Jalil Mirhosseini 1
Lida Hosseini 1
Seyedeh Mahdieh Namayandeh 1
Sima Mozafari 1

1 Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Department of Occupational Health Engineering, Genetic and Environmental Adventures Research Center, School of Abarkouh Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Department of Internal Medicine, BH10-642, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland

10.48305/arya.2025.45945.3126
Abstract
BACKGROUND: The hypertriglyceridemic waist phenotype (HTGW), a surrogate indicator of visceral adiposity, has been proposed as a simple screening tool for cardiometabolic risk. Limited information is available on the influence of HTGW and its temporal variations on the development of hypertension. This study examined the association between HTGW and decade-long hypertension incidence in an urban population of Iranian adults.
METHODS: Data were obtained from the Yazd Healthy Heart Project (YHHP). In its initial phase (2005–2006), 2,000 participants aged 20–74 years were enrolled. At baseline, demographic characteristics, blood pressure, anthropometric data, and biochemical tests were evaluated and reassessed in 2015–2016. After excluding individuals with hypertension at baseline, 1,269 normotensive participants were followed for approximately 10 years to assess incident hypertension, using multivariable logistic regression analyses in SPSS.
RESULTS: In this study, after excluding participants lost to follow-up, 786 participants were selected for the final analysis. The cumulative incidence of hypertension was 40.3% (317 out of 786). After adjustment for potential confounders, the risk of HTN was significantly higher among participants with hypertriglyceridemia (OR=2.38, 95% CI: 1.21–4.67) and those with HTGW (OR=1.88, 95% CI: 1.12–3.13) compared to those with normal waist and normal triglycerides (NWNT) in the total population. In men, there was a significant positive association between hypertriglyceridemia (OR=2.71, 95% CI: 1.22–6.02) and HTGW (OR=2.35, 95% CI: 1.23–4.47) and the 10-year incidence of HTN after multivariate adjustment.  
CONCLUSION: Our findings showed that hypertriglyceridemia and HTGW are independent predictors of 10-year hypertension incidence, particularly among men, in an Iranian urban adult population.

Keywords

Hypertension
Hypertriglyceridemic Waist
Incidence
Cohort Studies
Risk Factors
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ARYA Atherosclerosis Journal
Volume 22, Issue 1
January and February 2026
Pages 60-68

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