Document Type : Original Article
Authors
- Mahtab Mashayekhi 1
- Mahdokht Rezaei 1
- Narges Bazgir 2
- Monirsadat Mirzadeh 3
- Abbas Allami 1
- shahin aliakbari 4
- kimia Rahimi Ardali 1
1 Boali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
2 Hearing Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Assistant Professor, Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
4 aliakbarishahin@gmail.com
Abstract
Background: ST-segment elevation myocardial infarction (STEMI) results from coronary artery blockage due to ruptured atherosclerotic plaque. Eosinophils play a dual role in STEMI, contributing to thrombus formation and tissue repair. This study investigates the association between eosinophil percentage, platelet counts, and in-hospital prognosis in STEMI patients.
Methods: A cross-sectional study was conducted from September 2019 to February 2020, including patients aged 18 and above with a STEMI diagnosis. In-hospital mortality, arrhythmia, and left ventricular ejection fraction (LVEF) were recorded. Demographic data, clinical manifestations, and laboratory investigations were collected. Data were analyzed using SPSS (version 25.0), with a P value of <0.05 considered significant.
Results: The study included 100 STEMI patients with a mean age of 65±13.26 years; 75% were male. The mortality rate was 13%. A significant relationship was found between eosinophil percentage and mortality (p=0.032), and platelet count also correlated significantly with mortality (p=0.008). The association between eosinophil percentage and EF was significant (p<0.001). The area under the ROC curve was 0.705 (95% CI 0.605 - 0.792) for platelet counts and 0.679 (95% CI 0.577 - 0.770) for eosinophil percentage in differentiating live and expired patients.
Conclusions: Platelet count could be a significant prognostic indicator for in-hospital outcomes in STEMI patients, suggesting an increased risk of mortality. Additionally, there is a notable relationship between eosinophil percentage and ejection fraction (EF).
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