Document Type : Original Article

Author

• sediqeh jalali

Department of Biology, Payam Noor University, Po Box 4697-19395, Tehran, Iran

Abstract

Background: Liver X receptors (LXR) have an essential role in the regulation of cholesterol metabolism and their activation increase ABCG5 and ABCG8 genes expression for the improvement of cholesterol excretion from body during reverse cholesterol transport (RCT). The aim of this study was to investigate the effects of high intensity interval (HIT) and low intensity continuous (LIT) trainings on gene expression of these substances after a high fat diet in Wistar rats.
Methods: Fifteen male Wistar rats were divided into 3 groups: control group (n = 5), HIT exercise group (n = 5) and LIT exercise group (n = 5). All groups used a high fat diet for 13 weeks and the HIT and LIT groups performed the specific training program. The expression of LXRβ, ABCG5 and ABCG8 genes was measured after the training period.
Findings: Data analysis showed significant higher levels of LXRβ, ABCG5 and ABCG8 genes expression in HIT and LIT groups compared to the control group (P≤0.05).
Conclusion: HIT and LIT trainings after a high fat diet have beneficial effects on RCT that prevents heart attack. Also, HIT training may have a greater effect on cholesterol excretion during the reverse cholesterol transport mechanism than LIT.

Keywords

• Liver X Receptor
• Atherosclerosis
• Endurance Training
• Exercise
• Stroke