Document Type : Original Article


1 Dept. Physical Education, Farhangian University, P.O.Box 14665-889, Tehran, Iran

2 dept. Sport Sciences, Bu-Ali Sina University, Hamedan, Iran

3 Dept. Exersice Physiology, University of Guilan, Rasht, Iran



Background: The present study evaluated the effects of aerobic training with variable intensities on apoptotic indices of cardiac tissue in fatty diabetic rats.
Methods: Twenty-four male Wistar rats were randomly divided into non-diabetic (ND, n=8), trained diabetic (TD, n=8), and control diabetic (CD, n=8) groups. After high-fat dietary regimen, type 2 diabetes was induced by streptozotocin and blood glucose above 300 mg/dL were considered as an indicator of diabetes. The TD group underwent aerobic exercise five times a week for 6 weeks. Then, left ventricular end diastolic (LVEDV) and end systolic (LVESV), ejection fraction (EF%), catalase, caspase-9, P53, glucose, insulin, and HOMA-IR, were measured.
Results: Aerobic training resulted in a significant decrease in blood glucose levels (P < 0.01), caspase-9 (P < 0.05), HOMA-IR (P < 0.05), and P53 expression (P< 0.001) compared with the CD group. LVEDV and LVESV were significantly decreased (P < 0.05 and P < 0.05, respectively), while LVEF significantly increased (P < 0.05). Catalase activation increased insignificantly in the TD group pre- to post-training compared to CD.
Conclusions: Incremental aerobic exercise training (6 weeks) may have a cardioprotective effect in diabetic rats by decreasing apoptosis and oxidative stress indices, simultaneously increasing aerobic fitness and decreasing body weight.