Document Type : Original Article
Authors
- Mehdi Ghaderian 1
- Alireza Ahmadi, MD 2
- Narges Navabfar 3
- Mahammadreza Sabri 2
- Bahar Dehghan 4
- Chehreh Mahdavi 5
1 Associate professor of Pediatric Cardiology, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
2 Professor of Pediatric Cardiology, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
4 Assistant Professor of Pediatric Cardiology, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
5 Assistant Professor, Pediatric Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Because of cardiovascular complications, mortality is numerous in cyanotic patients with congenital heart disease (CHD). It has been determined that endothelial dysfunction, increased arterial stiffness, and a devastating vascular system negatively impacts cardiovascular prognosis. This study aimed to determine carotid-intima-media-thickness (CIMT) and flow-mediated dilatation (FMD) in the children group of cyanotic CHD (CCHD) patients.
Methods: In this case-control study, flow-mediated dilatation (FMD) and carotid-intima-media-thickness (CIMT) was assessed in 45 children with CCHD and 38 non-CCHD subjects during the years 2021-2022. The case group were matched with the controls in terms of age, and gender.
Results: 61.3% of participants were male, and the mean ± standard deviation age was 7.8 ± 5.39 years. CIMT and FMD insignificantly increased and decreased respectively in CCHD individuals, but systolic blood pressure was considerably higher in patients compared to the healthy group (P=0.003).
Conclusions: Children with CCHD had impaired FMD, but systolic blood pressure and CIMT were lower in controls. An increase in CIMT and systolic blood pressure may enhance the risk of developing atherosclerosis in CCHD patients.
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