Document Type : Original Article


1 Department of Health Research Methods Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

2 Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran



Background: Prevention and control of dyslipidemia, as an important risk factor for cardiovascular diseases (CVDs), is a priority for the healthcare system to reduce the burden of this diseases. The purpose of this protocol is to express the key steps of the first Iranian Dyslipidemia Clinical Practice Guideline development, which can be used by other researchers as a guide to design a standard, comprehensive, evidence-based, and local context-based guideline.

Methods: This guideline will be developed and reported according to the format of the World Health Organization (WHO) handbook for Guideline Development. All members of guideline development team will sign the declaration-of-competing-interests (DOI) forms. The development of our guideline will be supported by five groups: steering committee (SC), Guideline Developing Group (GDG), systematic review (evidence synthesis) group and external review group. We will also establish patient advisory group to inform guideline development by patients’ value and preferences. SC and GDG will determine the scope of the guideline and will design PICO questions. Systematic review group will systematically search Embase, PubMed, Scopus, Web of Sciences, Cochrane Library and Google Scholar from inception. Systematic review group will assess risk of bias and create evidence summaries using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The recommendations of this guideline will be divided into strong recommendation and weak or conditional recommendation or suggestion.

Conclusion: This clinical practice guideline will inform clinicians and health care professionals new evidence-based recommendations for diagnosis, management, and treatment of dyslipidemia in children and adults.