BACKGROUND: The present study aimed at evaluating the vasodilatory effect of nitroglycerin (NTG) in cardioplegia solution on changes in troponin I and creatine phosphokinase-MB (CPK-MB) levels during coronary artery bypass graft (CABG) surgery.
METHODS: The present randomized controlled double-blind clinical trial was performed on 44 patients that were candidates for CABG surgery. These patients were divided into two groups. In the first group (NTG group), 3 mg/kg NTG was added to the cardioplegia solution while 10 cc placebo (distilled water) was added to the cardioplegia solution in the second group (control group). Troponin I and CPK-MB levels were then assessed before and after the surgery.
RESULTS: The results of this study revealed that although the mean cardiopulmonary bypass (CPB) and cross-clamp time was higher in the NTG group as compared to the control group, this difference was not statistically significant. In addition, troponin I and CPK-MB levels after surgery in the NTG group with the mean of 2090.68 ± 1856.07 and 97.27 ± 38.17 were significantly lower than those of the control group with the mean of 2697.02 ± 5586.56 and 137.95 ± 227.99, respectively (P-value <0.05).
CONCLUSION: According to the results of the present study, although troponin I and CPK-MB levels increased significantly after CABG surgery, this increase was significantly lower in the intervention group as compared to the control group following the administration of NTG.