Document Type : Original Article


1 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate professor of cardiac surgery, Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran

3 General surgeon, Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran



Background: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been reported recently as potentially useful indicators of inflammation. Herein, we investigated their predictive role for postoperative complications of Coronary Artery Bypass Graft (CABG).

Methods: This study was performed on medical records of patients who had undergone isolated CABG in 2019-2020 in Isfahan, Iran. The baseline clinical characteristics were obtained from medical records. The diagnosis of postoperative AKI was defined based on the Kidney Disease Improving Global Outcomes guideline. The postoperative bleeding amount was measured from the total chest tube output during the ICU admission after surgery. NLR and PLR were measured by dividing the neutrophil and platelet to the lymphocyte, respectively. All the data were analyzed using the Statistical Package for Social Sciences (SPSS) version 24.

Results: Of 356 patients, data of 280 patients, including 219 males and 61 females were recruited. The mean age among all patients was 63.78±9.07 years. There were no significant differences between bleeding group and non-bleeding group regarding NLR (2.33(1.89-2.73) vs. 2.20(1.63-3)) and PLR(119.26(94.41-146.39) vs.110.26(82.13-136.34)) (p=0.742,p=0.228 respectively). NLR and PLR were significantly higher in AKI-positive patients (P< 0.001 and P=0.002, respectively).Only NLR showed the potential ability to predict postoperative AKI (P<0.001) based on the regression tests. Moreover, no significant correlation was seen between both NLR and PLR,hospital stay, ICU stay and in-hospital mortality.

Conclusion: Increase in NLR is associated with a higher risk for AKI after CABG. We found no significant correlations between NLR and PLR with bleeding and other complications.