ARYA Atherosclerosis Journal

Comparison of midazolam versus captopril in patients with uncomplicated hypertensive urgency in emergency ward: Double-blind randomized clinical trial

Document Type : Original Article(s)

Authors

Mohammad Reza Khorsand 1
Mostafa Enayatrad 2
Seyed Meysam Yekesadat 1
Maryam Khodayar 1
Amir Noyani 3

1 Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran

2 Clinical Research Development Unit, Bahar Hospital, Shahroud University of Medical Sciences, Shahroud, Iran

3 School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran AND Department of Emergency Medicine, Treetop Hospital, Male, Maldive

https://doi.org/10.48305/arya.2022.26128
Abstract
BACKGROUND: The urgency of uncomplicated blood pressure (BP) is known as a sudden rise in BP. The aim of this study was to evaluate the intravascular administration of midazolam as an emergency care to control BP against captopril in patients with uncomplicated hypertension (HTN).
METHODS: The present study was a double-blind parallel randomized clinical trial (RCT) study that was performed on patients with urgent HTN referred to Imam Hossein Hospital in Shahroud, Iran, in 2018. Patients with BP higher than 180/110 mmHg and with healthy vital organs were selected randomly and allocated into three groups of 43 participants. All patients’ BP in both arms, and after a period of 10 minutes in the left arm, was checked and after administering the medication was checked again for 4 times of 15 minutes till 1 hour complete.
RESULTS: There were significant differences between systolic (P = 0.024), diastolic (P = 0.001), and mean BP (P = 0.009) in the midazolam group before and after treatment. The group of midazolam and captopril showed the greatest reduction of BP before, in the middle, and after carrying out the treatment methods. As such, systolic, diastolic, and mean BP showed 23.5% (P = 0.047), 17.4% (P = 0.021), and 20.5% (P = 0.031) reduction, respectively.
CONCLUSION: Midazolam can be used as an effective and low-risk drug for lowering BP. Midazolam also has a faster effect on lowering BP.

Keywords

Hypertension
Midazolam
Captopril
Emergency Medicine
Clinical Trial
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ARYA Atherosclerosis Journal
Volume 18, Issue 4
April 2022
Pages 1-8

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