Document Type : Original Article

Authors

1 Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Assistant Professor, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Assistant Professor of Thoracic and cardiology surgery, Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences

Abstract

Background

The impact of gender on the pre-, intra-, and postoperative parameters and outcomes after coronary artery bypass graft (CABG) has conflicting results. The objectives of study were to identify differences in preoperative, intraoperative, and postoperative parameters and compare the postoperative complications and mortality between two genders who underwent CABG surgery.

Methods

This prospective observational study was conducted on patients who underwent isolated CABG and were divided based on sex. Demographic data, underlying comorbidities and drug history, clinical and laboratory data at the referral time, operative characteristics, postoperative variables, and mortality outcomes were monitored during hospitalization and six months after discharge.

Results

320 patients were included during the period of the study. 71% were men. Women had higher age (62.40±9.03 vs. 59.99±9.81 years, p= 0.011) and more presented with dyslipidemia (p=0.003), hypertension (p=0.000), and diabetes (p=0.001), whereas men more were admitted with myocardial infarction (MI) (p=0.011) and with lower Ejection fraction (EF) (p=0.001), also had lower EF in the post-surgery and six months after discharge (p <0.001, 0.006).

However, the number of vessel involvement was no different between genders (p=0.589) but the number of grafts was higher in men (p=0.008).

The overall mortality rate was no statistically significant difference between the two groups (4.42% and 6.38% in men and women, respectively, p= 0.464).

Conclusion

The women had more underlying comorbidities. Furthermore, there were some differences in the intra-operative parameters and postoperative complications between the two genders but there was no difference in mortality during the postoperative period in our setting.

Keywords