ARYA Atherosclerosis Journal

The relationship between lipid profile after fat loading and coronary artery disease severity assessed by SYNTAX score

Document Type : Original Article(s)

Authors

Nady A. Razik 1
Amgad Y. Deep 2
Mohamed Z. Abokrisha 3
Eman Mosad 3
Hosam Hasan-Ali 4

1 Lecturer of Cardiology, Cardiology Department, Assiut University. Cardiology Consultant, Sultan Qaboos Hospital, Oman

2 Cardiology Resident, Assiut General Hospital

3 Clinical Pathology Department, Assiut University

4 Cardiology Department, Assiut University

https://doi.org/10.48305/arya.2022.16286.2416
Abstract
BACKGROUND: Dyslipidemia is an established risk factor for coronary artery disease (CAD). Despite this, only half of CAD patients present with fasting dyslipidemia. Some reports have linked postprandial lipemia to atherosclerosis. 
We aimed to test the relationship between postprandial lipid profile (after fat loading) and CAD severity assessed by the SYNTAX score.
METHOD: We included 53 patients with documented CADs. We checked both fasting and postprandial (2 hours) lipograms after fat loading with 17 g/body surface area (m2). Then we assessed CAD severity via coronary angiography using the SYNTAX score. Our study is registered in clinicaltrials.gov (NCT03175393).
RESULTS: 53 patients with age 57.9 ± 7.82   were recuirted.  36 (68% ) of them were male .We observed a significant increase in postprandial triglycerides (TGs) (154.3 ±73.2 vs. 128.1 ± 69.4 mg/dl; P < 0.001), very-low-density lipoproteins (VLDL) (30.8 ± 14.6 vs. 25.6 ± 13.9 mg/dl; P < 0.001) as well as a significant decrease in the postprandial level of total cholesterol (162.4 ± 45.9 vs. 168.3 ± 46.0 mg/dl; P = 0.03) in comparison to their fasting level. 
We found that the SYNTAX score had a significant positive moderate correlation with 2-hour postprandial TGs (r = 0.55; P < 0.001) and 2-hour postprandial VLDL (r = 0.50; P < 0.001).
Based on the current study, predictors of high Syntax score were older age OR: 1.23(1.11-3.47; P< 0.001) post-prandial triglyceride 2.34 (1.89-5.66; P< 0.001) and post-prandial VLDL 1.76 (1.50-3.49; P< 0.001).
CONCLUSION: Postprandial lipograms, especially TGs, are significantly and positively related to CAD severity. 

Keywords

Total cholesterol
Lipogram
Postprandial lipogram, SYNTAX score
Triglycerides
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ARYA Atherosclerosis Journal
Volume 18, Issue 5
May 2022
Pages 1-9

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