ARYA Atherosclerosis Journal

Interleukin 10, lipid profile, vitamin D, selenium, metabolic syndrome, and serum antioxidant capacity in elderly people with and without cardiovascular disease: Amirkola health and ageing project cohort-based study

Document Type : Original Article(s)

Authors

Hamid Reza Nematollahi 1
Reza Hosseini 2
Ali Bijani 3
Haleh Akhavan-Niaki 4
Hadi Parsian 5
Mahdi Pouramir 5
Mehrdad Saravi 6
Mojgan Bagherzadeh 7
Abbas Mosapour 8
Massud Saleh-Moghaddam 9
Majid Rajabian 9
Monireh Golpour 10
Amrollah Mostafazadeh 11

1 Department of Biochemistry, School of Sciences, Payame Noor University of Mashhad, Mashhad, Iran

2 Professor, Social Determinants of Health Research Center AND Department of Community Medicine, Babol University of Medical Sciences, Babol, Iran

3 Assistant Professor, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

4 Professor, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

5 Professor, Department of Biochemistry, School of Sciences, Babol University of Medical Sciences, Babol, Iran

6 Associate Professor, Department of Cardiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

7 Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

8 PhD Candidate, Department of Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran

9 Professor, Department of Biochemistry, School of Sciences, Payame Noor University of Mashhad, Mashhad, Iran

10 PhD Candidate, Cellular and Molecular Biology Research Center AND Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

11 Associate Professor, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

https://doi.org/10.22122/arya.v15i5.1623
Abstract
BACKGROUND: The age-related autoinflammation-mediated atherosclerosis is associated with some immunological, nutritional, and metabolic parameters and redox status. Here, we evaluated the association of circulatory interleukin 10 (IL-10) levels with lipid profile, some nutrients, and total anti-oxidant capacity in elderly people who presented cardiovascular disease (CVD) with or without metabolic syndrome (MetS) and in healthy subjects.METHODS: In this cross-sectional case-control study, 258 sera prepared from elderly people (144 healthy and 114 patient subjects) who participated in a community-based study, the Amirkola Health and Ageing Project (AHAP), were analyzed for IL-10, lipid profile, vitamin D, selenium (Se), antioxidant capacity, and MetS.RESULTS: Compared to patients, the healthy subjects exhibited higher levels of circulatory IL-10 among individuals with detectable serum IL-10 (P = 0.036). However, this difference was not observed when total subjects from both groups were compared, since more than 90% of those people were IL-10-negative. Se, vitamin D, and antioxidant levels were similar in both groups. There was a negative association between IL-10 and body mass index (BMI) (P < 0.050) and an equivocal association with vitamin D levels, whereas the association between IL-10 and other indicated variables was not significant. Significant association was observed between MetS and CVD prevalence (P < 0.001). There was a positive correlation between Se and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) (P < 0.010) in healthy subjects and with TC in patients (P < 0.050).CONCLUSION: A major proportion of elderly people were serum IL-10-negative, whereas independently to IL-10, MetS was most common in patients with CVD. Weight loss may have the potential to increase IL-10 levels in the elderly.

Keywords

Interleukin 10
Lipids
Cardiovascular Diseases
Antioxidants
Metabolic Syndrome
Elderly
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ARYA Atherosclerosis Journal
Volume 15, Issue 5 - Serial Number 5
September and October 2019
Pages 233-240

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