ARYA Atherosclerosis Journal

Platelet indices and function response to two types of high intensity interval exercise and comparison with moderate intensity continuous exercise among men after coronary artery bypass graft: A randomized trial

Document Type : Original Article(s)

Authors

Vahid Sobhani 1
Mahmoudreza Taghizadeh 2
Maryam Moshkani-Farahani 3

1 Associate Professor, Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Exercise Physiologist, Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

3 Associate Professor, Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

https://doi.org/10.22122/arya.v14i5.1780
Abstract
BACKGROUND: It has been indicated that the acute exercise increases the thrombotic events that stem from platelet hyper-reactivity. The present randomized controlled trial study was carried out with the aim to compare high-intensity interval exercise (HIIE) with moderate intensity continuous exercise (MICE) in terms of platelet indices and function in patients who had undergone post coronary artery bypass graft (CABG).METHODS: 30 men with a history of CABG were recruited and divided into 3 groups (MICE, HIIE-1, and HIIE-2). The MICE protocol consisted of running for 40 minutes with 65% of maximal heart rate (HRmax). Subjects in HIIE-1 group performed an interval exercise with work to rest ratio of 1:1 in which 10 rounds of running (95% HRmax) were followed by active recovery (35% HRmax). HIIE-2 subjects performed an interval exercise with work to rest ratio of 2:1 in which 7 rounds of running (85% HRmax) were followed by active recovery (45% HRmax). Before and immediately after the exercise protocols, blood samples were taken from subjects and analyzed to measure the variables.RESULTS: Although platelet count (PLT) and hematocrit (HCT) were increased significantly after HIIE-1 and HIIE-2 in comparison to MICE (P < 0.050), the other platelet indices [mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT)] were not significantly changed among groups (P > 0.050). The platelet aggregation and fibrinogen were further increased after HIIE-1 and HIIE-2 as compared with MICE; however, such increment were significant between HIIE-2 and MICE (P < 0.050).CONCLUSION: It seems that HIIE, regardless of the type, has higher thrombotic potentials compared with MICE. Accordingly, MICE is safer than HIIE for rehabilitation in patients undergoing CABG.

Keywords

High-intensity Intermittent Exercise
Aerobic Exercise
Rehabilitation
Platelets
Fibrinogen
  1. Laslett LJ, Alagona P Jr, Clark BA 3rd, Drozda JP Jr, Saldivar F, Wilson SR, et al. The worldwide environment of cardiovascular disease: Prevalence, diagnosis, therapy, and policy issues: A report from the American College of Cardiology. J Am Coll Cardiol 2012; 60(25 Suppl): S1-49.
  2. Roques F, Nashef SA, Michel P, Gauducheau E, de Vincentiis C, Baudet E, et al. Risk factors and outcome in European cardiac surgery: Analysis of the EuroSCORE multinational database of 19030 patients. Eur J Cardiothorac Surg 1999; 15(6): 816-22.
  3. Willoughby S, Holmes A, Loscalzo J. Platelets and cardiovascular disease. Eur J Cardiovasc Nurs 2002; 1(4): 273-88.
  4. Unal EU, Ozen A, Kocabeyoglu S, Durukan AB, Tak S, Songur M, et al. Mean platelet volume may predict early clinical outcome after coronary artery bypass grafting. J Cardiothorac Surg 2013; 8: 91.
  5. Kobzar G, Mardla V, Ratsep I, Samel N. Platelet activity before and after coronary artery bypass grafting. Platelets 2006; 17(5): 289-91.
  6. Ivert T, Dalen M, Ander C, Stalesen R, Nasman P, Lordkipanidze M, et al. Platelet function one and three months after coronary bypass surgery in relation to once or twice daily dosing of acetylsalicylic acid. Thromb Res 2017; 149: 64-9.
  7. Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357(24): 2482-94.
  8. Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets 2006; 17(1): 67-9.
  9. Suaya JA, Shepard DS, Normand SL, Ades PA, Prottas J, Stason WB. Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery. Circulation 2007; 116(15): 1653-62.
  10. Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. Exercise-based rehabilitation for patients with coronary heart disease: Systematic review and meta-analysis of randomized controlled trials. Am J Med 2004; 116(10): 682-92.
  11. Moafi S, Zolaktaf V, Rabiei K, Hashemi Jazi M, Tarmah H, Sadegh M. Effect of home-based exercise rehabilitation on quality of life early post-dischargeafter coronary artery bypass graft and percutaneous coronary intervention. ARYA Atheroscler 2012; 7(Special Issue): S17-S22.
  12. Gibala MJ, Little JP, Macdonald MJ, Hawley JA. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol 2012; 590(5): 1077-84.
  13. Rognmo O, Hetland E, Helgerud J, Hoff J, Slordahl SA. High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil 2004; 11(3): 216-22.
  14. Cornish AK, Broadbent S, Cheema BS. Interval training for patients with coronary artery disease: A systematic review. Eur J Appl Physiol 2011; 111(4): 579-89.
  15. Albert CM, Mittleman MA, Chae CU, Lee IM, Hennekens CH, Manson JE. Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med 2000; 343(19): 1355-61.
  16. Wang JS. Exercise prescription and thrombogenesis. J Biomed Sci 2006; 13(6): 753-61.
  17. Alis R, Sanchis-Gomar F, Risso-Ballester J, Blesa JR, Romagnoli M. Effect of training status on the changes in platelet parameters induced by short-duration exhaustive exercise. Platelets 2016; 27(2): 117-22.
  18. Andreotti F, Lanza GA, Sciahbasi A, Fischetti D, Sestito A, De Cristofaro R, et al. Low-grade exercise enhances platelet aggregability in patients with obstructive coronary disease independently of myocardial ischemia. Am J Cardiol 2001; 87(1): 16-20.
  19. Ahmadizad S, Nouri-Habashi A, Rahmani H, Maleki M, Naderi N, Lotfian S, et al. Platelet activation and function in response to high intensity interval exercise and moderate continuous exercise in CABG and PCI patients. Clin Hemorheol Microcirc 2016; 64(4): 911-9.
  20. Guiraud T, Nigam A, Gremeaux V, Meyer P, Juneau M, Bosquet L. High-intensity interval training in cardiac rehabilitation. Sports Med 2012; 42(7): 587-605.
  21. Guiraud T, Nigam A, Juneau M, Meyer P, Gayda M, Bosquet L. Acute responses to high-intensity intermittent exercise in CHD patients. Med Sci Sports Exerc 2011; 43(2): 211-7.
  22. Guiraud T, Juneau M, Nigam A, Gayda M, Meyer P, Mekary S, et al. Optimization of high intensity interval exercise in coronary heart disease. Eur J Appl Physiol 2010; 108(4): 733-40.
  23. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 1974; 37(2): 247-8.
  24. El-Sayed MS, El-Sayed AZ, Ahmadizad S. Exercise and training effects on blood haemostasis in health and disease: An update. Sports Med 2004; 34(3): 181-200.
  25. Wang JS, Jen CJ, Kung HC, Lin LJ, Hsiue TR, Chen HI. Different effects of strenuous exercise and moderate exercise on platelet function in men. Circulation 1994; 90(6): 2877-85.
  26. Whittaker JP, Linden MD, Coffey VG. Effect of aerobic interval training and caffeine on blood platelet function. Med Sci Sports Exerc 2013; 45(2): 342-50.
  27. Ahmadizad S, Bassami M, Hadian M, Eslami M. Influences of two high intensity interval exercise protocols on the main determinants of blood fluidity in overweight men. Clin Hemorheol Microcirc 2016; 64(4): 827-35.
  28. Alis R, Ibanez-Sania S, Basterra J, Sanchis-Gomar F, Romagnoli M. Effects of an acute high-intensity interval training protocol on plasma viscosity. J Sports Med Phys Fitness 2015; 55(6): 647-53.
  29. Ikarugi H, Shibata M, Ishii K, Yamamoto J. Shear-induced platelet reactivity in middle-aged women after low-intensity exercise. Thromb Res 2001; 104(5): 347-51.
  30. Knowlton RG, Hetzler RK, Kaminsky LA, Morrison JJ. Plasma volume changes and cardiovascular responses associated with weight lifting. Med Sci Sports Exerc 1987; 19(5): 464-8.
  31. Kargotich S, Goodman C, Keast D, Morton AR. The influence of exercise-induced plasma volume changes on the interpretation of biochemical parameters used for monitoring exercise, training and sport. Sports Med 1998; 26(2): 101-17.
  32. Sjogaard G, Adams RP, Saltin B. Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension. Am J Physiol 1985; 248(2 Pt 2): R190-R196.
  33. Mongirdiene A, Kubilius R. Effect of physical training on indices of platelet aggregation and fibrinogen concentration in patients with chronic heart failure. Medicina (Kaunas) 2015; 51(6): 343-50.
  34. Mehta J, Mehta P. Comparison of platelet function during exercise in normal subjects and coronary artery disease patients: Potential role of platelet activation in myocardial ischemia. Am Heart J 1982; 103(1): 49-53.
  35. Hilberg T, Menzel K, Glaser D, Zimmermann S, Gabriel HH. Exercise intensity: Platelet function and platelet-leukocyte conjugate formation in untrained subjects. Thromb Res 2008; 122(1): 77-84.
  36. Wang JS. Intense exercise increases shear-induced platelet aggregation in men through enhancement of von Willbrand factor binding, glycoprotein IIb/IIIa activation, and P-selectin expression on platelets. Eur J Appl Physiol 2004; 91(5-6): 741-7.
  37. Ikarugi H, Taka T, Nakajima S, Noguchi T, Watanabe S, Sasaki Y, et al. Norepinephrine, but not epinephrine, enhances platelet reactivity and coagulation after exercise in humans. J Appl Physiol (1985) 1999; 86(1): 133-8.
  38. Wang JS, Cheng LJ. Effect of strenuous, acute exercise on alpha2-adrenergic agonist-potentiated platelet activation. Arterioscler Thromb Vasc Biol 1999; 19(6): 1559-65.
  39. Zouhal H, Jacob C, Delamarche P, Gratas-Delamarche A. Catecholamines and the effects of exercise, training and gender. Sports Med 2008; 38(5): 401-23.
  40. McClean C, Harris RA, Brown M, Brown JC, Davison GW. Effects of exercise intensity on postexercise endothelial function and oxidative stress. Oxid Med Cell Longev 2015; 2015: 723679.
ARYA Atherosclerosis Journal
Volume 14, Issue 5 - Serial Number 5
September and October 2018
Pages 188-195

Home

Guide for Authors

Submit Manuscript

Reviewers

Contact Us