ARYA Atherosclerosis Journal

The role of human T-lymphotropic virus (HTLV) in cardiovascular diseases: A review of literature

Document Type : Review Article

Authors

Samaneh Abolbashari 1
Majid Ghayour-Mobarhan 2
Mahmoud Ebrahimi 3
Zahra Meshkat 4

1 PhD Candidate, Student Research Committee AND Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Professor, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Associate Professor, Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4 Associate Professor, Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

https://doi.org/10.22122/arya.v14i4.1608
Abstract
Cardiovascular diseases are a major cause of morbidity and mortality. Chronic inflammation is an important risk factor for atherosclerosis, and viral infections can cause cardiovascular disease by developing inflammation. Infection with human T-lymphotropic virus (HTLV) is endemic in some parts of the world such as Japan, Africa, Caribbean islands, South America, and Iran. HTLV-1 is an oncogenic retrovirus, and can cause adult T-cell leukemia/lymphoma (ATL or ATLL). It also causes HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A number of inflammatory diseases such as uveitis, arthritis, and Sjogren's syndrome are also associated with the virus. A few case reports have shown the direct involvement of the heart in HTLV-1-positive patients who develop ATLL. The purpose of this study was to review the literature relevant with the role of HTLV in cardiovascular diseases.

Keywords

Cardiovascular Disease
HTLV Infection
Atherosclerosis
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ARYA Atherosclerosis Journal
Volume 14, Issue 4 - Serial Number 4
July and August 2018
Pages 183-187

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