Association between ABO blood group and severity of coronary artery disease in unstable angina

Omidi, Negar; Khorgami, Mohammad Rafie; Effatpanah, Mohammad; Khatami, Farnaz; Mashhadizadeh, Mehrpouya; Jalali, Arash; Hekmat, Hamidreza

Association between ABO blood group and severity of coronary artery disease in unstable angina

Document Type : Original Article(s)

Authors

Negar Omidi ¹

Mohammad Rafie Khorgami ²

Mohammad Effatpanah ³

Farnaz Khatami ⁴

Mehrpouya Mashhadizadeh ⁵

Arash Jalali ⁶

Hamidreza Hekmat ⁷

¹ Assistant Professor, Cardiac Primary Prevention Research Center, Tehran Heart Center, AND Department of Cardiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

² Assistant Professor, Rajaie Heart Center AND Department of Pediatric Cardiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

³ Assistant Professor, Department of Psychiatry, School of Medicine, Ziaeian Hospital, International Campus, Tehran University of Medical Sciences, Tehran, Iran

⁴ Assistant Professor, Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

⁵ Student of Medicine, Department of Cardiology, School of Medicine International Campus, Tehran University of Medical Sciences, Tehran, Iran

⁶ Assistant Professor, Tehran Heart Center AND Department of Research, Tehran University of Medical Sciences, Tehran, Iran

⁷ Assistant Professor, Department of Cardiology, School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

Abstract

BACKGROUND: ABO blood groups are genetically transmitted through chromosome 9 at locus 9q34. It is supposed that there is a locus on 9p21, which has a role in developing coronary artery disease. METHODS: Our study population consisted of 309 patients with unstable angina admitted to the Ziaeian Hospital, Tehran, Iran, who underwent coronary angiography. The association between types of blood group (O and non-O) with the severity of coronary artery disease was investigated. RESULTS: Compared to the non-O groups, the O group had more severe coronary artery involvement (P = 0.004). CONCLUSION: Our study supports recent suggestions on the association between blood group and coronary artery disease. Further studies are needed to evaluate the effect of blood group on atherosclerosis.

Keywords

ABO Blood Group System

Blood Group

Coronary Artery Disease, Unstable Angina

Acute Coronary Syndrome, Myocardial Ischemia

Angina Pectoris

Atherosclerosis

Califf RM, Armstrong PW, Carver JR, D'Agostino RB, Strauss WE. 27th Bethesda Conference: matching the intensity of risk factor management with the hazard for coronary disease events. Task Force 5. Stratification of patients into high, medium and low risk subgroups for purposes of risk factor management. J Am Coll Cardiol 1996; 27(5): 1007-19.
Sari I, Ozer O, Davutoglu V, Gorgulu S, Eren M, Aksoy M. ABO blood group distribution and major cardiovascular risk factors in patients with acute myocardial infarction. Blood Coagul Fibrinolysis 2008; 19(3): 231-4.
Franchini M, Capra F, Targher G, Montagnana M, Lippi G. Relationship between ABO blood group and von Willebrand factor levels: From biology to clinical implications. Thromb J 2007; 5: 14.
O'Donnell J, Boulton FE, Manning RA, Laffan MA. Amount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels. Arterioscler Thromb Vasc Biol 2002; 22(2): 335-41.
Yamamoto F, Clausen H, White T, Marken J, Hakomori S. Molecular genetic basis of the histo-blood group ABO system. Nature 1990; 345(6272): 229-33.
Yip SP. Sequence variation at the human ABO locus. Ann Hum Genet 2002; 66(Pt 1): 1-27.
Schmitz G, Kaminski WE. ABCA2: A candidate regulator of neural transmembrane lipid transport. Cell Mol Life Sci 2002; 59(8): 1285-95.
McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007; 316(5830): 1488-91.
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 2007;
(5830): 1491-3.
Carpeggiani C, Coceani M, Landi P, Michelassi C, L'abbate A. ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study. Atherosclerosis 2010; 211(2): 461-6.
Amirzadegan A, Salarifar M, Sadeghian S, Davoodi G, Darabian C, Goodarzynejad H. Correlation between ABO blood groups, major risk factors, and coronary artery disease. Int J Cardiol 2006; 110(2): 256-8.
Jones WB, Riley CP, Reeves TJ, Sheffield LT. Natural history of coronary artery disease. Bull N Y Acad Med 1972; 48(9): 1109-25.
Shi Y, Lin Y, Liu H, Ji Q, Lu Z, Lu Z, et al. Association between ABO blood groups and coronary heart disease in Chinese Guangxi Zhuang population. Zhonghua Xin Xue Guan Bing Za Zhi 2015; 43(9): 788-92.
Biswas S, Ghoshal PK, Halder B, Mandal N. Distribution of ABO blood group and major cardiovascular risk factors with coronary heart disease. Biomed Res Int 2013; 2013: 782941.
Dodiya D, Panchal V, Patel G, Nayak M. Association of ABO blood groups with coronary artery disease in Gujarati population. Indian Journal of Applied Basic Medical Sciences 2013; 15b(21): 66-72.
Sujirachato K, Worasuwannarak W, Srisont S, Udnoon J, Peonim V. ABO Blood Group and Coronary Atherosclerosis in Thais at Ramathibodi Hospital. Siriraj Med J 2015; 67(2): 53-9.
Whincup PH, Cook DG, Phillips AN, Shaper AG. ABO blood group and ischaemic heart disease in British men. BMJ 1990; 300(6741): 1679-82.
McKeigue PM, Marmot MG, Adelstein AM, Hunt SP, Shipley MJ, Butler SM, et al. Diet and risk factors for coronary heart disease in Asians in northwest London. Lancet 1985; 2(8464): 1086-90.