ARYA Atherosclerosis Journal

Pentoxifylline and prevention of contrast-induced nephropathy: Is it efficient in patients with myocardial infarction undergoing coronary angioplasty?

Document Type : Original Article(s)

Authors

Ali Eshraghi 1
Roya Naranji-Sani 2
Hourak Pourzand 3
Mohammad Vojdanparast 4
Negar Morovatfar 5
Javad Ramezani 1
Ramin Khamene-Bagheri 1
Pouya Nezafati 6

1 Assistant Professor, Atherosclerosis Prevention Research Center AND Department of Cardiology, Imam Reza School of Medicine, Imam Reza Hospital, Mashhad, University of Medical Sciences, Mashhad, Iran

2 Resident, Department of Cardiology, Imam Reza School of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

3 Associate Professor, Atherosclerosis Prevention Research Center AND Department of Cardiology, Imam Reza School of Medicine, Imam Reza Hospital, Mashhad, University of Medical Sciences, Mashhad, Iran

4 Cardiologist, Atherosclerosis Prevention Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

5 Assistant Professor, Imam Reza Clinical Research Units, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

6 General Practitioner, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan, Iran

Abstract
BACKGROUND: Contrast-induced nephropathy (CIN) is a major concern following procedures with applying iodinated contrast media. The basis prevention of CIN is hydration and to avoid hypovolemia. We aimed to evaluate the efficacy of pentoxifylline (PTX) for the prevention of CIN in patients with myocardial infarction (MI) undergoing coronary angioplasty. METHODS: This prospective, single-blind, randomized clinical trial study was performed on 175 (127 men) of MI patients undergoing routine treatment. Patients were assigned randomly to the control (n = 84) and study groups (n = 91). In our study group, patients received 400 mg/3 times a day from 24 hours before to 24 hours after coronary angiography. In addition, before the procedure and after 48 hours from the procedure, serum creatinine was measured. RESULTS: CIN occurred in 14 patients (8.0%); 8 controls (9.5%) and 6 patients (6.6%) in the PTX group )P = 0.475) showing PTX to have no significant effect on CIN [P = 0.750, odds ratio = 0.82 (confidence interval = 0.24-2.8)] though a significantly different volume of contrast was used between the groups (231.29 ± 105.10 mm3 and 190.88 ± 75.82 mm3; P = 0.005, respectively). CONCLUSION: There was no significantly different occurrence of CIN on patients with MI, undergoing coronary angioplasty, but its relatively lower rate in PTX group would recommend the prophylactic oral use of PTX for CIN prevention. 

Keywords

Pentoxifylline
Myocardial Infarction
Contrast Media
Angioplasty
Nephropathy
Creatinine
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ARYA Atherosclerosis Journal
Volume 12, Issue 5 - Serial Number 5
September and October 2016
Pages 238-242

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