Prevalence of non-alcoholic fatty liver disease in patients with coronary artery disease

Baharvand-Ahmadi, Babak; Sharifi, Khalil; Namdari, Mehrdad

Prevalence of non-alcoholic fatty liver disease in patients with coronary artery disease

Document Type : Short Communication

Authors

Babak Baharvand-Ahmadi ¹

Khalil Sharifi ²

Mehrdad Namdari ¹

¹ Associate Professor, Khorramabad Heart Center AND Department of Cardiology, Shahid Madani Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran

² Assistant Professor, Lorestan University of Medical Sciences, Khorramabad, Iran

Abstract

Background: Several common metabolic risk factors contribute to development of both non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD). The aim was to determine prevalence of NAFLD in patients with CAD. Methods: This prospective study was carried out from December2011 to June2012. All patients with documented diagnosis of CAD with stenosis of one of the main coronary arteries or their branches were included in the study. Ultrasound examination of liver was performed in all patients to diagnose hepatic steatosis. Accordingly the severity of steatosis was graded from 0 (absence of steatosis) to 3 (severe steatosis). Finally, prevalence of NAFLD was determined in the studied patients. Results: Among 170 patients with CAD included in the study, 63 and 17 cases respectively, had grade 1 and grade 2 hepatic steaotosis in ultrasound examination providing prevalence of 47% in studied population. There was no significant differences between patients with NAFLD and those without NAFLD regarding gender (p= 0.12), presence of diabetes mellitus (p=0.27), hyperlipidemia (p=0.21) and hypertension (p=0.87). There was no association between involvement of left anterior descending artery and hepatic steatosis (p=0.87). Conclusions: The present study indicated a high prevalence of NAFLD in patients with documented CAD.

Keywords

Non-Alcoholic Fatty Liver Disease

Coronary Artery Disease

Ultrasound

Chen CH, Nien CK, Yang CC, Yeh YH. Association between nonalcoholic fatty liver disease and coronary artery calcification. Dig Dis Sci 2010; 55(6): 1752-60.
Sotoudehmanesh R, Sotoudeh M, Ali-Asgari A, Abedi-Ardakani B, Tavangar SM, Khakinejad A, et al. Silent liver diseases in autopsies from forensic medicine of Tehran. Arch Iran Med 2006; 9(4): 324-8.
Alavian SM, Mohammad-Alizadeh AH, Esna-Ashari F, Ardalan G, Hajarizadeh B. Non-alcoholic fatty liver disease prevalence among school-aged children and adolescents in Iran and its association with biochemical and anthropometric measures. Liver Int 2009; 29(2): 159-63.
Lankarani KB, Ghaffarpasand F, Mahmoodi M, Lotfi M, Zamiri N, Heydari ST, et al. Nonalcoholic fatty liver disease in southern Iran: a population based study. Hepat Mon 2013; 13(5): e9248.
Tuyama AC, Chang CY. Non-alcoholic fatty liver disease. J Diabetes 2012; 4(3): 266-80.
Arbab-Zadeh A, Nakano M, Virmani R, Fuster V. Acute coronary events. Circulation 2012; 125(9): 1147-56.
Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983; 51(3): 606.
Saverymuttu SH, Joseph AE, Maxwell JD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J (Clin Res Ed) 1986; 292(6512): 13-5.
Acikel M, Sunay S, Koplay M, Gundogdu F, Karakelleoglu S. Evaluation of ultrasonographic fatty liver and severity of coronary atherosclerosis, and obesity in patients undergoing coronary angiography. Anadolu Kardiyol Derg 2009; 9(4): 273-9.
Kim D, Choi SY, Park EH, Lee W, Kang JH, Kim W, et al. Nonalcoholic fatty liver disease is associated with coronary artery calcification. Hepatology 2012; 56(2): 605-13.
Assy N, Djibre A, Farah R, Grosovski M, Marmor A. Presence of coronary plaques in patients with nonalcoholic fatty liver disease. Radiology 2010; 254(2): 393-400.
Gastaldelli A, Kozakova M, Hojlund K, Flyvbjerg A Favuzzi A, Mitrakou A, et al. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population. Hepatology 2009; 49(5): 1537-44.
Villanova N, Moscatiello S, Ramilli S, Bugianesi E, Magalotti D, Vanni E, et al. Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease. Hepatology 2005; 42(2): 473-80.
Foster KJ, Dewbury KC, Griffith AH, Wright R. The accuracy of ultrasound in the detection of fatty infiltration of the liver. Br J Radiol 1980; 53(629): 440-2.
Yajima Y, Ohta K, Narui T, Abe R, Suzuki H, Ohtsuki M. Ultrasonographical diagnosis of fatty liver: significance of the liver-kidney contrast. Tohoku J Exp Med 1983; 139(1): 43-50.
Angelico F, Del Ben M, Conti R, Francioso S, Feole K, Maccioni D, et al. Non-alcoholic fatty liver syndrome: a hepatic consequence of common metabolic diseases. J Gastroenterol Hepatol 2003; 18(5): 588-94.