ARYA Atherosclerosis Journal

Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial

Document Type : Short Communication

Authors

Mohsen Moohebati 1
Shima Yazdandoust 2
Amirhossein Sahebkar 3
Mohsen Mazidi 2
Zahra Sharghi-Shahri 2
Gordon Ferns 4
Majid Ghayour-Mobarhan 5

1 Associate Professor, Cardiovascular Research Center AND Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Assistant Professor, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4 Professor, Brighton and Sussex Medical School, Mayfield House, University of Brighton, Brighton, UK

5 Associate Professor, Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract
BACKGROUND: Small dense low-density lipoprotein (sdLDL) is a sub-fraction of LDL considered to have the most atherogenic properties. The present trial aimed to assess changes in circulating sdLDL concentrations following supplementation with curcuminoids, polyphenolic compounds with diverse potential cardio-protective functions. METHODS: This study was designed as a randomized double-blind placebo-controlled cross-over trial. A total of 30 obese dyslipidemic subjects were assigned to curcuminoids (1 g/day) or placebo for 4 weeks, followed by a 2-week washout and then treatment with the alternate for another 4 weeks. Serum sdLDL was measured at baseline and weeks 4, 6, and 10 of the trial. RESULTS: Supplementation with curcuminoids (1 g/day) did not cause any significant alteration in serum sdLDL (P > 0.05). CONCLUSION: Four-week supplementation with curcuminoids was not associated with any significant alteration in circulating sdLDL concentrations.   Keywords: Diferuloylmethane, Curcuma longa L., Turmeric, Cardiovascular Disease, Hypercholesterolemia, Atherosclerosis 
ARYA Atherosclerosis Journal
Volume 10, Issue 5 - Serial Number 5
September and October 2014
Pages 280-286

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