Pediatric patients with renal disease and cardiovascular complications: A literature review

Karbasi-Afshar, Reza; Saburi, Amin; Taheri, Saeed

Pediatric patients with renal disease and cardiovascular complications: A literature review

Document Type : Review Article

Authors

Reza Karbasi-Afshar ¹

Amin Saburi ²

Saeed Taheri ³

¹ Assistant Professor, Department of Cardiology AND Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

² Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

³ Dr. Taheri Medical Research Group, Tehran, Iran

Abstract

The cardiovascular burden of end stage renal disease (ESRD) in children has recently received more attention, and some authors have recommended that the origins of the increase in cardiovascular morbidity and mortality be found in childhood. In this comprehensive review of the literature, we aim to review the main and most recent studies evaluating cardiovascular risk factors in pediatric kidney disease patients. The literature suggests that ESRD, even in the pediatric population, is associated with a high rate of cardiovascular morbidity and mortality, and needs serious attention. Unfortunately, there is extreme scarcity of data on the efficacy of preventive strategies on cardiovascular morbidity and mortality in pediatric patients with renal disease. Therefore, authors of the current article recommend future studies to be directed to find beneficial and/or potential harmful effects of different interventions conventionally used in this population, including lifestyle modifications and pharmaceutical therapy on cardiovascular indices. Moreover, the effects of these drugs on the renal function of children with minimal kidney disease should be evaluated. Keywords: Cardiovascular Complication, Children, Kidney Disease, Pediatrics