Document Type : Original Article(s)
1 Assistant Professor, Department of Cardiology, Imam Khomeini Hospital of Lorestan University of Medical Sciences, Lorestan
2 Associate Professor, Department of Cardiology, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan
3 General Practitioner, Imam Khomeini Hospital of Lorestan University of Medical Sciences, Lorestan
4 Lecture, Department of Statistics, School of Health, Lorestan University of Medical Sciences, Lorestan
5 BSc in Nursing, Imam Khomeini Hospital of Lorestan University of Medical Sciences, Lorestan
BACKGROUND: Hypertension (HTN) is one of the most important problems in all parts of the world. Although the disease is usually asymptomatic, its diagnosis and treatment are easy. The aim of this study was to compare the effect of Nifedipine (Adalat®), Captopril and sublingual Nitroglycerin on reducing blood pressure (BP).
METHODS: This study was a parallel group randomized controlled trial. From the patients referred to our heart clinic, 120 patients with severe HTN were enrolled in the study. The patients were randomly allocated into 3 groups A, B, and C. The patients were advised to use 5 drops of Adalat in group A, Captopril 25 mg sublingually in group B, and 1 sublingual Nitroglycerin pearl in group C. The BP was measured every 20 minutes during one hour.
RESULTS: Systolic BP was reduced significantly by Adalat and Captopril compared with sublingual Nitroglycerin in the 20th, 40th and 60th minutes (P = 0.001), but there was no significant difference between Adalat and captopril in reducing systolic BP. In addition, the result of reducing diastolic BP was not significantly different among the three groups.
CONCLUSION: We saw the same effect on reducing BP by Captopril, Adalat, and sublingual Nitroglycerin. Among these three drugs, the side effects of Captopril were the least frequent. Adalat caused headache and flushing. Thus, it seems Captopril can be used instead of Adalat in medical centers.
Keywords: Adalat, Captopril, Nitroglycerin, Severe Hypertension