AbstractINTRODUCTION: Atherosclerotic renal artery stenosis (RAS) is an important cause ofsecondary hypertension as well as ischemic nephropathy. Little information is availableabout the incidence of RAS in hypertensive patients in the Iranian society. This study wasperformed to determine the prevalence of RAS and its related risk factors in hypertensivepatients.METHODS: A cross-sectional study was conducted on 122 hypertensive patients (80males and 42 females) aged 33-74 years (mean age: 54±8.5 years), all of whomunderwent coronary angiography and selective renal angiography.RESULTS: According to angiographic data, 95 patients (77.9%) had coronary arterydisease (CAD) and 27 (22.1%) had normal coronary arteries. RAS was seen in 22 patients(23.1%) with CAD and hypertension, and in 4 patients (14.8%) with hypertension andnormal coronary arteries. Overall, 26 patients (21.3%) had RAS, which was classified assignificant (14.7%) and non-significant (6.6%). RAS significantly correlated to the femalegender (P=0.019), age (P=0.002), diabetes mellitus (P=0.025) and severity ofhypertension (P=0.006).CONCLUSIONS: The prevalence of significant RAS among hypertensive patientsundergoing coronary angiography was 14.7%. Factors like old age, severe hypertension,diabetes mellitus and female gender were clinical predictors of RAS.Key Words: Hypertension, renal artery stenosis, coronary artery disease, coronaryartery angiography.