Document Type : Original Article(s)
1 M.Sc. Animal Physiologist, Research assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences.
2 Abbaszadeh, MD, Internist, Isfahan University of Medical Sciences.
3 Rafiei, B.S. Nutritionist, Director of Medical Education and Development Center, Isfahan University of Medical Sciences.
4 MD, Assistant Professor of Internal Medicine, Isfahan University of Medical Sciences.
5 Neurologist, Tehran University of Medical Sciences.
AbstractINTRODUCTION: Some studies have shown that C-reactive protein (CRP) and uricacid may have a role in development of coronary artery disease (CAD); the role cigarettesmoking plays in CAD through various mechanisms has also been demonstrated. Hence,the question is raised: does cigarette smoking exert its atherogenic effect throughincreasing CRP and uric acid levels in the serum? The first step in responding to thisquestion would be to study the relationship between cigarette smoking, CAD, CRP anduric acid levels. As cigarette smoking is highly prevalent in Iran, the present study wasconducted to compare mean serum levels of CRP and uric acid in 3 groups of activesmokers, passive smokers, and non-smokers, to determine any possible associationbetween cigarette smoking and serum CRP and uric acid levels.METHODS: The study involved 177 men aged 20-40 years in 3 groups of activesmokers, passive smokers, and non-smokers (59 individuals in each group). In addition,fasting blood samples were taken from all subjects to measure serum levels of CRPserologically and uric acid photometrically (using ELAN 2000). Questionnaires onanthropometrics, personal information, disease history, drug use and other relatedsubjects were completed for all the subjects.RESULTS: Mean serum CRP levels were 5.4