THE EFFECT OF WEIGHT LOSS ON PLASMA MDA, LIPIDS PROFILE AND APOA AND APOB IN OBESE WOMAN

Ramezani, Fatemeh; Keshavarz, Ali; Jalali, Mahmud; Eshraghian, Mohamadreza; Chameri, Maryam

THE EFFECT OF WEIGHT LOSS ON PLASMA MDA, LIPIDS PROFILE AND APOA AND APOB IN OBESE WOMAN

Document Type : Original Article(s)

Authors

Fatemeh Ramezani ¹

Ali Keshavarz ²

Mahmud Jalali ³

Mohamadreza Eshraghian ⁴

Maryam Chameri ¹

¹ MSc. Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran.

² PhD. Professor of Nutrition, Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran.

³ PhD. Professor of Biochemistry, Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sci-ences, Tehran.

⁴ PhD. Associate Professor. Department of Biostatistic, School of Health, Tehran University of Medical Sciences, Tehran.

Abstract

Abstract INTRODUCTION: Obesity increased reactive oxygen species generation that it result in oxidative injury on lipids profile and lipoproteins that all of which insert atherosclerotic effect. Nutritional intervention by means of a hypocaloric diet could produce protective effects against the redox unbalance. In this context, the aim of this intervention trial was to estimate the ability of weight loss to improve oxidative stress biomarkers related to lipids peroxidation and lipid profile and apoproteins concentrations of serum in obese women. METHODS: Thirties eight obese women, 15-45 years old, with body mass index (BMI <30 kg/m2 were recruited. The obese women were assigned to energy-restricted dietary treatments for 12 week. Before and after nutritional intervention and 10% weight reduction, anthropometric measurements were taken and fasting blood was drawn. Plasma levels of (MDA) determined with TBAR and triglyceride, total cholesterol and HDL cholesterol. Keywords: MDA, lipid profile, obese woman, Weight loss.