Document Type : Original Article(s)

Authors

• Masoud Mozafari ¹
• Masoumeh Sadeghi ²
• Hamid Sanei ³
• Mohammad Arash Ramezani ⁴
• Allahyar Golabchi ¹
• Nizal Sarrafzadegan ⁵

¹ Cardiology Resident, Isfahan University of Medical Sciences, Isfahan

² Associate Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan

³ Associate Professor of Cardiology, Isfahan University of Medical Sciences, Isfahan

⁴ Community Medicine Specialist, Isfahan Cardiovascular Research Center, Isfahan

⁵ Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences Isfahan

Abstract

BACKGROUND: Leptin and adiponectin are two adipose tissue hormones and their association with the incidence of cardiovascular diseases is under evaluation. The aim of this study was to determine the relationship of leptin and adiponectin with coronary artery diseases.    METHODS: One hundred and seventy patients with angina pectoris and indications of coronary angiography underwent angiography. Serum levels of blood lipids, leptin, and adiponectin were measured. The gathered data was evaluated using SPSS software, V. 15, by multivariate variance analysis.    RESULTS: Analysis of the data demonstrated that 45.1% of the patients had positive angiographic findings. The serum levels of leptin and adiponectin were significantly lower than the minimum levels specified by the kit. However, the two groups, i.e., patients with positive angiographic findings and those with negative findings were not significantly different according to the serum levels of the hormones. Moreover, no significant correlation between the serum levels of the hormones and serum lipids was observed.     CONCLUSION: Various studies have demonstrated that high serum level of leptin and the incidence of coronary artery diseases are correlated. On the other hand, they have reported that adiponectin has cardioprotective role. Confirmation of these findings requires more detailed studies.    Keywords: Leptin, Adiponectin, Coronary artery disease