Cardiovascular research institute, Isfahan University of Medical SciencesARYA Atherosclerosis Journal1735-395515420190811Effects of an orientation tour on preoperative anxiety in candidates for coronary artery bypass grafting: A randomized clinical trial1541601068910.22122/arya.v15i4.1806ENReyhanehNiknejadMSc Student, Student Research Committee, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-9610-3295MohsenMirmohammad-SadeghiAssociate Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranMohammadAkbariCardiac Rehabilitation Research Center, Cardiovascular Research Institute AND Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-9258-2831AhmadGhadamiAssistant Professor, Nursing and Midwifery Care Research Center AND Department of Operating Room, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran0000-0001-6681-5403Journal Article20180601BACKGROUND: Candidates for cardiac surgery usually suffer from preoperative anxiety. Although there are various anxiety reduction techniques, it is unclear which one is the most effective. Therefore, the present study was conducted to explore the effects of an orientation tour on preoperative anxiety in candidates for coronary artery bypass grafting (CABG).METHODS: In this randomized clinical trial study, 70 patients who were candidate for CABG were recruited from February 2016 to May 2017. They were randomly assigned to two groups of 35. The intervention group members were taken on an orientation tour and the control group received routine care. Data were collected using the State-Trait Anxiety Inventory (STAI).RESULTS: The statistical tests revealed that there was no significant difference between the intervention group (42.43 ± 13.24) and the control group (45.11 ± 10.19) with respect to the pre-intervention state anxiety level (P = 0.340); however, before surgery, the state anxiety level was significantly lower in the intervention group (34.83 ± 11.15) than in the control group (47.69 ± 11.30) (P < 0.001). Moreover, the independent t-test showed that there was no significant difference between the intervention (43.71 ± 12.04) and control (45.03 ± 8.76) groups with respect to the pre-intervention trait anxiety level (P = 0.600). Nevertheless, before surgery, the trait anxiety level was significantly lower in the intervention group (35.40 ± 10.24) than in the control group (46.91 ± 9.51) (P < 0.001).CONCLUSION: The preoperative orientation tour had a positive impact on the anxiety level in the candidates for CABG. Hence, the tour can be used as a remarkably effective technique for reducing anxiety. https://arya.mui.ac.ir/article_10689_b8043b9b976639acb17b035ab8963f18.pdfCardiovascular research institute, Isfahan University of Medical SciencesARYA Atherosclerosis Journal1735-395515420190811Correlation between air pollution and hospitalization due to myocardial infarction1611671069010.22122/arya.v15i4.1834ENZeynabDavoodabadiCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-3622-5175AzamSoleimaniHeart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-2529-5223AliPourmoghaddasInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-5684-0426Sayed MohsenHosseiniDepartment of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, IranTohidJafari-KoshkiRoad Traffic Injury Research Center AND Department of Statistics and Epidemiology, School of Health, Tabriz University of Medical Sciences, Tabriz, IranMojtabaRahimiDepartment of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMansourShishehforoushIsfahan Disaster Management Office, Isfahan Governor’s Office, Isfahan, IranAhmadrezaLahijanzadehKhouzestan Department of Environment, Ahvaz, IranBabakSadeghianCentral Laboratory and Air Pollution Monitoring, Isfahan Province Environmental Monitoring Center, Isfahan Department of Environment, Isfahan, IranElhamMoazamCancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, IranMohammad BagherMohebiInformation Technology Office, Isfahan University of Medical Sciences, Isfahan, IranVictoriaEzatianIsfahan Meteorological Office, Isfahan, IranKatayounRabieiIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranNizalSarrafzadeganIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20180722BACKGROUND: Air pollution is associated with increased risk of cardiovascular disease (CVD). This study aims to evaluate the correlation between air pollutants and hospitalization due to myocardial infarction (MI) as part of "correlation of air pollution with hospitalization and mortality of CVDs and respiratory diseases (CAPACITY) study".METHODS: This case-crossover study analyzed the data of 319 patients who were admitted with diagnosis of ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI) in three main hospitals of Isfahan, Iran. The data of airborne pollutants including particulate matter < 10 µm (PM10), particulate matter < 2.5 µm (PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), and ozone (O3) as well as climatic indices (temperature, wind speed, and humidity) at 24 hours, 48 hours, and one week before admission were extracted from CAPACITY study. The conditional logistic regression method was used to evaluate the correlation between air pollutants and MI hospitalization.RESULTS: 319 patients with mean age of 63.15 ± 28.14 years, including 238 men (74.6%), and 207 patients with STEMI (64.8%) were recruited. The risk of hospitalization significantly increased in patients with STEMI and 10-unit increment in PM2.5 at 48 hours before admission [odds ratio (OR) = 3.70, 95% confidence interval (CI): 1.69-7.69]. Although, majority of air pollutants had positive association with hospitalization in patients with NSTEMI, they were not statistically significant.CONCLUSION: This study showed significant association between elevated PM2.5 at 48 hours before admission and hospitalization of patients with STEMI. This finding can warn policymakers to design better care services for patients at risk of acute MI during the times of increased air pollution.https://arya.mui.ac.ir/article_10690_79e0effe60c1d4c057037f430cd25b73.pdfCardiovascular research institute, Isfahan University of Medical SciencesARYA Atherosclerosis Journal1735-395515420190819The effect of canola oil compared with sesame and sesame-canola oil on cardio-metabolic biomarkers in patients with type 2 diabetes: Design and research protocol of a randomized, triple-blind, three-way, crossover clinical trial1681781069110.22122/arya.v15i4.1940ENMojganAmiriNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran0000-0003-4936-4609Mohammad TaghiGhaneianProfessor, Environmental Science and Technology Research Center AND Department of Environmental Health Engineering, Shahid Sadoughi University of Medical Sciences, Yazd, IranMohammad JavadZare-SakhvidiAssociate Professor, Occupational Health Research Center AND Department of Occupational Health, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranMasoudRahmanianAssistant Professor, Diabetes Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranAzadehNadjarzadehAssociate Professor, Nutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranFatemehMoghtaderiNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranHamidrezaRaeisi-DehkordiNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranAlirezaZimorovatNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranFatemeJafariNutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran0000-0002-3342-0242JavadZavar-RezaProfessor, Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranAlirezaJahan-MihanAssociate Professor, Department of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USAMohammad RezaAghaei-MeybodiDiabetes Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranAminSalehi-AbargoueiAssociate Professor, Nutrition and Food Security Research Center AND Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran0000-0002-7580-6717Journal Article20181219BACKGROUND: Both canola and sesame oils consumption have been associated with favorable effects on cardio-metabolic biomarkers. However, to the best of our knowledge, no study has compared their effects on cardiovascular risk factors. The present study aimed to assess the effect of canola, sesame, and sesame-canola oils consumption on cardio-metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM).METHODS: This study was a randomized, triple-blind, three-way, crossover clinical trial. The study participants included 102 individuals with T2DM. Their spouses were also included in the study. The participants were entered into a 4-week run-in period. After that, their regular dietary oil was replaced with canola, sesame, or sesame-canola oils (a blend of sesame and canola oils) in three 9-week phases, which were separated by two 4-week washout periods (sunflower oil was consumed during the run-in and the washout periods). Dietary, physical activity, blood pressure, and anthropometric measurements were assessed at the beginning, in the middle (week 4-5), and at the end of each treatment phase. Blood samples were taken at the beginning and at the end of each phase. Serum, plasma, buffy coat, and whole blood samples were extracted and kept at -80 ºC for further analysis. Serum fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were selected as the primary outcomes.RESULTS: 102 participants with T2DM were randomly assigned to one of the 6 rolling methods. Through them, 93 individuals (91.2%) completely participated in all phases.CONCLUSION: The present study will provide an exceptional opportunity to examine the effect of canola, sesame, and sesame-canola oil on cardio-metabolic markers in adults with and without T2DM. This trial will also provide a good medium for the investigation of gene-dietary oils interaction in the future.https://arya.mui.ac.ir/article_10691_77b88288ebae7b17b7c8610a48c40dd1.pdfCardiovascular research institute, Isfahan University of Medical SciencesARYA Atherosclerosis Journal1735-395515420190819Immunohistochemical analysis of adiponectin in atherosclerotic lesions of human aorta1791841069210.22122/arya.v15i4.1873ENDmitry A.TanyanskiyDepartment of Biochemistry, Institute of Experimental Medicine AND Department of Fundamental Medicine and Medical Technology, Saint Petersburg State University, Saint Petersburg, Russia0000-0002-5321-8834Peter V.PigarevskiiAssociate Professor, Department of General and Special Morphology, Institute of Experimental Medicine, Saint Petersburg, RussiaSvetlana V.MaltsevaDepartment of General and Special Morphology, Institute of Experimental Medicine, Saint Petersburg, RussiaAlexander D.DenisenkoProfessor, Department of Biochemistry, Institute of Experimental Medicine AND Department of Fundamental Medicine and Medical Technology, Saint Petersburg State University, Saint Petersburg, RussiaJournal Article20180925BACKGROUND: Metabolic syndrome, a cluster of interrelated disorders including abdominal obesity, insulin resistance, dyslipidemia, and hypertension (HTN) plays an important role in development of atherosclerotic lesions in arterial wall. Dysregulation of adipose tissue hormones (adipokines) production is a possible link between abdominal obesity and other manifestations of metabolic syndrome. Adiponectin is a well-known adipokine which affects metabolism and inflammatory response. However, data on its role in atherogenesis are still controversial. The aim of this study is to investigate whether adiponectin is present in atherosclerotic lesions of human aorta.METHODS: Thirty-five autopsy segments from abdominal, thoracic aortas, and aortic arch of four men (mean age: 57 years) were fixed and stained for lipids [Oil Red O (ORO)], cells [hematoxylin-eosin (H&E)], and adiponectin [indirect immunoperoxidase assay (IPA) method]. Samples of both stable and unstable plaques were selected for analysis. Human adipose tissue, THP-1 monocytes/macrophages, and human endothelial hybrid cell line (EA.hy926) were chosen for detection of adiponectin messenger ribonucleic acid (mRNA) using reverse transcription polymerase chain reaction (RT-PCR).RESULTS: Adiponectin accumulations were found inside endothelial cells covering both stable and unstable atherosclerotic plaques. Focal depositions of adiponectin were also found in fibrous caps of stable lesions and atheromatous core of both stable and unstable plaques and also in adventitia. RT-PCR revealed mRNA expression of adiponectin gene in adipose tissue, but not in mononuclears and endothelial cells.CONCLUSION: Adiponectin is present in aortic plaques of humans, but is not synthesized in endothelial cells and mononuclears, at least in culture conditions. Detection of adiponectin in atherosclerotic lesions can serve as indirect evidence of possible participation of this adipokine in atherogenesis. https://arya.mui.ac.ir/article_10692_8640ff6ca914c9855203ac93e4c05119.pdfCardiovascular research institute, Isfahan University of Medical SciencesARYA Atherosclerosis Journal1735-395515420190911Comparing efficacy of receiving different dosages of eptifibatide in bleeding after percutaneous coronary intervention in patients with myocardial infarction1851911069310.22122/arya.v15i4.1668ENHasanShemiraniProfessor, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-8977-6360AlirezaKhosraviProfessor, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran0000-0003-0736-2090AliEghbalResident, Student Research Committee AND Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-5585-4295AfshinAmirpourAssistant Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranFarshadRoghaniAssociate Professor, Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-8529-7522Seyed MohammadHashemi-JaziProfessor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranAliPourmoghaddasProfessor, Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran0000-0002-5684-0426RaminHeidariAssistant Professor, Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranAmirSajjadiehAssistant Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranNahidSadeghiIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranHamidSaneiProfessor, Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20170816BACKGROUND: Acute coronary syndrome (ACS) is a common condition that needs appropriate treatment like percutaneous coronary intervention (PCI). Glycoprotein IIb/IIIa inhibitors (GPI) like eptifibatide prevent procedural ischemic complications after PCI. Eptifibatide has increased the risk of bleeding complications, although it is effective in reducing mortality and morbidity. Eptifibatide is routinely used in bolus and infusion forms and the aim of this study is to evaluate the efficacy of bolus-only dose and bolus + infusion strategy for administrating eptifibatide in bleeding complications and consequences after PCI.METHODS: This randomized clinical trial was conducted on subjects who experienced PCI after incidence of myocardial infarction (MI). Patients were randomly divided into two groups who received bolus-only dose (n = 51) or bolus + infusion form of eptifibatide (n = 50). Then, PCI blood pressure, mean time duration of hemostasis after arterial sheath removal, laboratory data, need for blood transfusion, and presence of bleeding complications were evaluated. After 6 months, patients were followed for needs for additional coronary interventions.RESULTS: The mean age of participants was 61.68 ± 1.50 years. The prevalence of men was 70.29%. There was no significant difference in mean of systolic blood pressure (SBP) and diastolic blood pressure (DBP) during hospitalization (P > 0.050). The mean time duration of hemostasis was 8.13 ± 0.45 minutes in the bolus-only group and 16.46 ± 0.71 minutes in the bolus + infusion group (P < 0.001). There was no significant difference in the hemoglobin (Hb) level, platelet count, white blood cell (WBC), blood urea nitrogen (BUN), and creatinine level (P > 0.050).CONCLUSION: The results of this study suggested that bolus-only dose of eptifibatide before PCI could be able to decrease significantly bleeding complication and other clinical and cardiovascular outcomes.https://arya.mui.ac.ir/article_10693_a8fbbd3b11424ce032ba813493d95ad7.pdfCardiovascular research institute, Isfahan University of Medical SciencesARYA Atherosclerosis Journal1735-395515420190811Stressors in open-heart surgery patients: A qualitative study1922001069410.22122/arya.v15i4.1840ENSoheilaSedaghatNursing Care Research Center in Chronic Disease Care, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0003-4590-4807ShahnazRostamiNursing Care Research Center in Chronic Disease Care, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran0000-0002-8013-0344AbbasEbadiBehavioral Sciences Research Center, Life Style Institute, School of Nursing, Baqiyatallah University of Medical Sciences, Tehran, IranMalekFereidooni-MoghadamNursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20180804BACKGROUND: Open-heart surgery is a stressful experience for the patients and their families. From the moment that patients are told they must undergo surgery until discharge, they experience different degrees of worry and nervousness. This study was conducted with the aim of identifying stress factors in heart surgery patients.METHODS: This study was performed using a qualitative method on 21 participants (14 patients and 7 caregivers). The research environment was open-heart surgery wards of two educational hospitals in Ahwaz (south of Iran) in 2017. The participants were selected through purposive sampling. The data were collected through semi-structured interviews, and then, analyzed using the qualitative approach of content analysis proposed by Graneheim and Lundmnan (2004).RESULTS: The 5 themes of “physical stressors”, “self-care stressors”, “psychological stressors”, “religious stressors”, and “hospital stressors” were obtained. These themes were the result of the patients’ experiences and dimensions of patients’ perceptions regarding stressors in open-heart surgery.CONCLUSION: Stress in patients undergoing open-heart surgery is a contextual and relative concept and a subjective experience, which is experienced as a sense of worry. Identifying and clarifying stressors in open-heart surgery patients for nurses is vital, like a key for improving care quality. Nursing managers in clinical practice can also benefit from these findings regarding heart surgery in improving the care quality and professional performance of nurses. https://arya.mui.ac.ir/article_10694_c1234a24b3825382a0e1ac3e1d925b13.pdfCardiovascular research institute, Isfahan University of Medical SciencesARYA Atherosclerosis Journal1735-395515420190824Wolff-Parkinson-White syndrome and de Winter patterns; An implication for paying special attention to electrocardiogram2012041069510.22122/arya.v15i4.1842ENMostafaAhmadiAssistant Professor, Department of Cardiovascular Diseases, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran0000-0002-2462-0162RaminKhameneh-BagheriAssistant Professor, Department of Cardiovascular Diseases, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMohammadVojdanparastAssistant Professor, Department of Cardiovascular Diseases, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranRezaJafarzadeh-EsfehaniPhD Candidate, Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran0000-0002-9177-994XJournal Article20180805BACKGROUND: Despite recent advances in diagnostic techniques in cardiology, electrocardiography (ECG) has yet remained the first and corner stone of detecting emergency cardiac events including myocardial infarction (MI). There are some ECG findings which are considered as equivalents to MI. De Winter ST-T wave pattern is one of the important ECG findings which is thought to be related to left anterior descending artery occlusion. However, the coexistence of this ECG pattern with other ECG abnormalities are not reported widely. In this report, we discussed a unique case of de Winter ST-T wave pattern in a patient with Wolff-Parkinson-White (WPW) syndrome for the first time.CASE REPORT: A 43-year-old man was referred because of an intermittent typical chest pain. The patient had no cardiovascular risk factor, and was not on any medication; laboratory tests showed elevated and raising troponin I. The first ECG showed pre-excitation (WPW) as well as de winter pattern. According to patient’s symptoms and suggestive ECG for probable left anterior descending (LAD) occlusion, emergent angiography was scheduled. The coronary angiography revealed sever LAD artery occlusion. The patient was symptom free after successful percutaneous coronary intervention, and was discharged on medication. The patient remained asymptomatic in 1-year follow-up period.CONCLUSION: Presence of de Winter ST-T changes with other ECG abnormalities is a rare issue, and here we addressed the first case of WPW and de Winter. The physicians should be aware that ECG changes in patients with WPW should not be interpreted as de Winter ST-T changes and vice versa.https://arya.mui.ac.ir/article_10695_445dc1bd2498d250b1a65a9bbe4bb5d9.pdfCardiovascular research institute, Isfahan University of Medical SciencesARYA Atherosclerosis Journal1735-395515420190701Journal Index1068810.22122/arya.v15i4.2082ENIndexJournal0000-0002-0105-6095Journal Article20191128Click to download the index of this issue. https://arya.mui.ac.ir/article_10688_73c83a253e66cb5877f2d7f8beeba07f.pdf