Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 22 Issue 2 2026 03 01 ST-segment elevation differential diagnosis in a patient with ovarian cancer: A case report 1 4 33252 10.48305/arya.2026.45246.3056 EN Faezeh Dehghani-Tafti Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0001-9266-8128 Mahmood Emami-Meybodi Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-5121-0054 Seyed Mostafa Seyed Hossieni Tezerjani Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0001-7115-6596 Roghayeh Pourkia Babol University of Medical Sciences, Department of Cardiology, School of Medicine, Babol, Iran 0000-0002-8013-7888 Journal Article 2025 05 23 Across the world the incidence of cancer is predicted to increase by 47% over the next 20 years. Increasingly, cardiologists will be faced with patients presenting with acute coronary syndromes, who are receiving active treatment for cancer. On the other hand, metastasis of malignant tumors to the heart is not usual but can present with various clinical features such as pericardial effusion, heart failure, arrhythmia, and myocardial infarction. Rarely, they may cause characteristic electrocardiographic changes, resembling ST-segment elevated myocardial infarction (STEMI). Decision making in this scenario is complex and requires detailed knowledge of the patient’s cancer stage, response to cancer treatment, and overall prognosis. Proper diagnosis is critical in these patients to prevent unnecessary or even harmful interventions such as fibrinolytic therapy. We reported a 45-year-old woman with a history of ovarian carcinoma, who presented with atypical chest pain and ECG findings suggestive myocardial infarction. But after full investigation we realized these ECG changes were due to the myocardial invasion of the tumor not coronary atherosclerosis and obstruction.

https://arya.mui.ac.ir/article_33252_da84b5e0e99f3999917feb3a31afec8d.pdf

Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 22 Issue 2 2026 03 01 A roy adaptation model–based care program and its impact on quality of life in patients with acute coronary syndrome: A randomized controlled trial 5 16 33161 10.48305/arya.2025.45561.3089 EN Miaad Mirzapour Student Research Committee, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran 0009-0001-1005-6011 Mohsen Shahriari Nursing and Midwifery Care Research Center, Medical Surgical Nursing Department, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-7833-0187 Sima Babaei Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-3836-5211 Journal Article 2025 10 11 BACKGROUND: Acute coronary syndrome (ACS), a clinical manifestation of chronic coronary artery disease, is often associated with multiple complications, recurrent hospitalizations, and diminished quality of life. Evaluating quality of life is a key outcome for determining the effectiveness of clinical and educational interventions. This study examined the impact of a care program grounded in the Roy Adaptation Model (RAM) on the quality of life of patients with ACS. METHODS: In this randomized controlled trial, 76 patients with ACS were randomly assigned to either the intervention or control group. Data collection took place from July to December 2024. Participants in the intervention arm received a two‑week educational care program grounded in the Roy Adaptation Model, delivered through in‑person sessions and supplemented with an instructional booklet. Data were gathered using a demographic survey, the SF‑36 quality‑of‑life instrument, and the Roy Adaptation Model assessment form, which were administered at baseline and at one and three months following the intervention. RESULTS: Independent t‑tests revealed no significant pre‑intervention differences in physical, mental, or overall quality‑of‑life scores between the groups. Following the intervention, the intervention group demonstrated significant improvements. Repeated‑measures ANOVA confirmed significant main effects of time and time‑by‑group interaction. Subscale analysis demonstrated significant improvements in seven of the eight SF‑36 domains in the intervention group. In contrast, the control group exhibited a significant improvement only in general health. CONCLUSION: The Roy Adaptation Model provides an effective framework for fostering adaptation and enhancing quality of life in cardiac patients.

https://arya.mui.ac.ir/article_33161_2511e300780ede704e51ed05e5d306db.pdf

Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 22 Issue 2 2026 03 01 The effects of whey protein-based beverage formulation on the expression of genes related to lipid metabolisms, muscle function, and oxidative stress in trained mice 17 25 33162 10.48305/arya.2025.43538.3039 EN Alieh Abdolrezaie Department of Biochemistry, Fal.C., Islamic Azad University, Isfahan, Iran Hashem Nayeri Department of Biochemistry, Fal.C., Islamic Azad University, Isfahan, Iran 0000-0002-4334-9064 Ali Mohammad Ahadi Department of Genetics, School of Science, Shahr-e-Kord University, Shahr-e-Kord, Iran Ali Nasirpour Department of Food Science and Technology, Isfahan University of Technology, Isfahan, Iran Ahmad Bagheri Moghadam Isfahan Sport Medicine Board, Isfahan, Iran Journal Article 2025 04 28 BACKGROUND: The expression of metabolic genes can be changed by the simultaneous effect of endurance exercise and nutrition. The aim of this study was to verify the effects of endurance exercise and whey protein consumption on the expression of Fibronectin type III domain-containing protein 5 (FNDC5), Paraoxonase-1 (PON1), and proliferator-activated receptor alpha (PPARα) genes in muscle. METHODS: A total of twenty BalB/C male mice were accidentally selected and subsequently divided into four groups, with each group consisting of five mice. The groups were as follows: placebo, exercised, whey-supplemented, and exercise plus whey-supplemented. In the groups involving exercise, the animals underwent treadmill exercise three times per week. The expression of FNDC5, PON1, and PPARα genes was analyzed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Finally, GraphPad Prism 9.0 software was used to statistically evaluate changes in gene expression, and one-way analysis of variance (ANOVA) at the p<0.05 level and Tukey’s multiple comparison test. RESULTS: FNDC5 gene expression in muscle increased in the groups that were supplemented with whey or exercised, compared to the placebo group. Investigations did not show a significant difference in FNDC5 expression in the liver between the whey-supplemented, exercise plus whey-supplemented, and placebo groups. In both liver and muscle tissue, whey protein increased the expression of PON1 (P = 0.001) regardless of exercise. PPARα expression also increased in muscle tissue. Additionally, the expression of PON1 in muscle was higher in the whey-supplemented group compared to the exercise and placebo groups. CONCLUSION: The consumption of whey protein and its interaction with exercise can significantly contribute to the modification of energy and lipid metabolism, muscle function, and oxidative stress through increased metabolic gene transcription.

https://arya.mui.ac.ir/article_33162_30fb29ade62fcc64db06d1001676c913.pdf

Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 22 Issue 2 2026 03 01 Hypertension and 10-year risk of coronary artery diseases in adult population: Yazd healthy heart project 26 34 33164 10.48305/arya.2025.45949.3127 EN Mohammadtaghi Sarebanhassanabadi Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-8867-4717 Mahdieh Mousavirad Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Physical Medicine & Rehabilitation, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Lida Hosseini Department of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran Pedro Marques-Vidal Department of Internal Medicine, BH10-642, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland Alexander Kraemer Department of Health Sciences, Bielefeld University, Bielefeld, Germany Seyedeh Mahdieh Namayandeh Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Clinical Research Development Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0003-3616-2864 Hamideh Mihanpour Department of Occupational Health Engineering, Genetic and Environmental Adventures Research Center, School of Abarkouh Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-3886-6323 Sima Mozafari Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0003-4960-2718 Journal Article 2025 11 30 BACKGROUND: The incidence of coronary artery disease (CAD) is influenced by several risk factors, including hypertension. Although the association between hypertension and CAD has been investigated in Western countries, limited research has been conducted in Asia and the Middle East. We investigated the association between hypertension and the 10‑year risk of CAD in the adult population. METHODS: In this cohort study, 2,000 participants aged 20 to 74 years in the Yazd Healthy Heart Project were enrolled in 2005–2006 and followed up to 2015–2016. Participants with a history of CAD were excluded. At baseline, data on demographic characteristics, anthropometric measurements, biochemical blood tests, and lifestyle factors were collected. The association between hypertension and approximately 10‑year CAD risk was assessed using the Cox regression model. RESULTS: The baseline prevalence of hypertension among adults was 36.1%. During the ten‑year follow‑up, CAD incidence was 16.8% in men, 12.0% in women, and 14.5% in the total population. After adjusting for potential confounders, hypertension increased the risk of CAD in men (HR = 1.64; 95% CI: 1.09–2.46), women (HR = 2.16; 95% CI: 1.15–4.05), and the whole sample (HR = 1.73; 95% CI: 1.23–2.43). This association was similar in men and women (p for interaction ≥0.05). CONCLUSION: This study demonstrated a significant association between hypertension and CAD risk, highlighting the need for targeted interventions in populations with hypertension to reduce CAD risk.

https://arya.mui.ac.ir/article_33164_6008ee3996caf132da3a30be8a14dc73.pdf

Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 22 Issue 2 2026 03 01 Endovascular stenting for coarctation of the aorta in Infants and young children in southeast Iran: A retrospective study 35 46 33213 10.48305/arya.2026.45312.3062 EN Fatemeh Doost-Mohammadi Clinical Research Development Unit, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran 0000-0003-3867-4214 Reza Derakhshan Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran 0000-0001-6630-8161 Journal Article 2025 06 02 BACKGROUND: Coarctation of the aorta (CoA) in infants and young children is typically treated with high-risk open-heart surgery. Endovascular stenting provides a less invasive alternative; however, its safety and efficacy remain underexplored. This study aimed to evaluate procedural success, complications, and four-year outcomes of stenting for CoA. METHODS: A retrospective review included 30 infants and young children (28 days to 3 years of age, weight >2.5 kg) with CoA who underwent endovascular stenting in Kerman and Sistan-Baluchestan, Iran, from 2024 to 2025. Patients with complex heart defects requiring immediate surgery or weighing <2.5 kg were excluded. Diagnostics utilized echocardiography, femoral angiography (for gradient assessment), and CT angiography. Outcomes included reduction in gradient, minor complications (hematoma, transient arrhythmia, localized bleeding, and bruising), major complications (stent thrombosis, vascular rupture, stent migration, vascular injury, sepsis, and mortality), and stent patency. RESULTS: Procedural success was achieved in 27 out of 30 patients (90%, 95% CI: 73.5–97.9%). The mean gradient was reduced by 89% (from 45 ± 10 mmHg to 5 ± 3 mmHg, p<0.001). Minor complications occurred in 3 of 30 patients (10%; 95% CI: 2.1–26.5%), including 2 hematomas and 1 transient arrhythmia; no major complications or mortality were reported. Four-year stent patency was 90% (95% CI: 73.5–97.9%); 3 out of 30 patients (10%) required re-dilation at 2.5 years due to growth. Cox regression analysis found no predictors for re-intervention (p>0.05). CONCLUSION: Endovascular stenting seems to be a safe and effective alternative for CoA in infants and young children. Larger prospective studies are necessary.

https://arya.mui.ac.ir/article_33213_2ffe5ae29bb6b60145835654b541b443.pdf

Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 22 Issue 2 2026 03 01 Comparison of postoperative complications following CABG in diabetic and non-diabetic patients 47 54 33214 10.48305/arya.2026.45487.3081 EN Akram Ghadiri-Anari Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-9430-4894 Farnaz Bemaninejad Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Seyedeh Mahdieh Namayandeh Clinical Research Development Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0003-3616-2864 Reyhaneh Azizi Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-0996-045X Mohammadreza Ahi Clinical Research Development Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0003-2600-5515 Journal Article 2025 07 22 BACKGROUND: Diabetic patients face an elevated cardiovascular disease burden, often requiring coronary artery bypass grafting (CABG). However, evidence regarding post-CABG outcomes in diabetic versus non-diabetic patients is inconsistent, and data from the Iranian population are particularly scarce. This study was conducted to clarify this ambiguity by comparing short-term post-CABG complications between these groups.. METHODS: A retrospective cohort study analyzed data from the Yazd Cardiovascular Disease Registry (YCDR) for all CABG patients (2017–2018) at Afshar Hospital. Patients were stratified into diabetic (n=592) and non-diabetic (n=694) groups. We collected standardized data on demographics, comorbidities (including diabetes), and in-hospital major postoperative complications following CABG, such as reoperation, mortality, infections, renal complications, neurological complications (including TIA, stroke, and seizure), and pulmonary complications. RESULTS: The frequency distribution of female sex (36.66% vs. 21.90%), hypertension (65.03% vs. 44.52%), and hyperlipidemia (39.02% vs. 23.20%) in diabetic patients was significantly higher than in non-diabetic patients (p<0.001). No statistically significant differences were observed between diabetic and non-diabetic groups in the incidence of major complications, including reoperation (2.1% vs. 2.3%), mortality (3.2% vs. 2.4%), and other major events (all p>0.05). However, seizure occurred exclusively in the diabetic group (1.1% vs. 0%; p=0.049). Logistic regression analysis demonstrated that diabetes mellitus was not an independent predictor of overall postoperative complications. CONCLUSION: In this cohort, diabetes was not an independent risk factor for most short-term post-CABG complications. The exception was a higher seizure incidence in diabetic patients, warranting further mechanistic investigation. Larger prospective studies are needed to confirm these findings.

https://arya.mui.ac.ir/article_33214_6264104f24cbc6849b7e6ad298862a24.pdf

Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 22 Issue 2 2026 03 01 The effect of diabetes mellitus on aortic valve stenosis and its treatment outcome: A meta-analysis review 55 66 33187 10.48305/arya.2026.45869.3119 EN Alireza Hosseini Department of Cardiovascular Surgery, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-5201-4995 Asieh Maghami-Mehr Department of Statistics, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-4104-9324 Hamed Khesali Department of Cardiovascular Surgery, Isfahan University of Medical Sciences, Isfahan, Iran 0009-0000-1557-7564 Journal Article 2025 12 15 BACKGROUND: Given the importance of diabetes mellitus (DM) and its role in the development of aortic valve stenosis (AVS), as well as its association with adverse outcomes after aortic valve replacement (AVR), the present meta analysis aimed to provide a comprehensive review of previous studies in this field. METHODS: To achieve this objective, a thorough literature search was conducted in PUBMED/MEDLINE, ScienceDirect, CINAHL, EMBASE/SCOPUS, PsycINFO, ClinicalKey, the Cochrane Central Register of Controlled Trials (CENTRAL), ProQuest, Web of Science, and Persian databases such as SID and Magiran. The number of patients, gender ratio, mean age, prevalence of T2DM, AVS, and treatment outcomes after TAVI, TAVR, and SAVR (stroke, early and late mortality) were recorded. RESULTS: This meta‑analysis comprised 22 studies involving a total of 760,287 patients with AVS. The pooled prevalence of DM was approximately 31% (95% CI: 26–36%). DM was associated with a significantly higher risk of early mortality, including both in‑hospital mortality (OR: 2.399) and 30‑day mortality (OR: 1.45), compared with non‑DM patients (p<0.05). However, the increase in late mortality (one year or longer) among DM patients was not statistically significant. Additionally, DM patients showed a significantly elevated risk of stroke compared with non‑DM patients (OR: 1.15; 95% CI: 1.03–1.28; p=0.009). CONCLUSION: Overall, DM appears to play a significant role in the development of AVS and is associated with adverse outcomes including mortality and stroke after AVR.

https://arya.mui.ac.ir/article_33187_cc73ed6fa658dab4deb142aa5266cff7.pdf