Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 21 Issue 3 2025 04 01 Determinants of severity of pain in non-cardiac chest pain patients: A cross sectional study 49 58 32874 10.48305/arya.2025.43240.3010 EN Hamidreza Roohafza Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0003-3582-0431 Danesh Heidari Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Awat Feizi Department of Biostatistics and Epidemiology, School of health, Isfahan University of Medical Sciences, Isfahan, Iran Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0002-1930-0340 Azam Khani Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0003-4423-7694 Kasra Shokri Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0001-8529-1078 Sara Bagherieh Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Niloufar Yavari Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Parsa Saneian Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Ali Karami Students' Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Masoumeh Sadeghi Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 0000-0001-7179-5558 Journal Article 2024 12 04 <strong>BACKGROUND:</strong> This study aims to explore the psychosocial factors related to the severity of pain in patients with non-cardiac chest pain (NCCP), providing insights to support more comprehensive and targeted management strategies.    <br /><strong>METHODS:</strong> This cross-sectional study was conducted at two university-affiliated hospitals. Patients diagnosed with NCCP, based on physical examination and angiographic findings, completed questionnaires assessing type D personality, cardiac anxiety, fear of bodily sensations, somatization, depression, and pain severity. Univariate and multiple logistic regression analyses were conducted to identify factors influencing pain severity levels.<br /><strong>RESULTS: </strong>A total of 156 males and 204 females, with a mean age of 55.76 ± 12.83 years, were divided into low-pain (N = 182) and high-pain (N = 178) groups. Higher education and being female were significantly associated with greater pain severity. Depression, type D personality, somatization, and cardiac anxiety were significantly correlated with pain severity. Multiple logistic regression analysis indicated that self-rated health (OR,: 2.14; 95% CI. :1.18-3.90), depression (OR-11.15; 95% CI-:1.09-1.22), type D personality (OR-: 1.90; 95% CI-: 1.06- 3.41), somatization (OR-: 1.03; 95% CI-: 1.01-1.06), and fear of bodily sensation (OR-: 1.90; 95% CI-: 1.06-3.41), were all associated with pain severity. <br /><strong>CONCLUSION:</strong> This study concluded that type D personality, fear of bodily sensations, depression, somatization, cardiac anxiety, and poor self-rated health were associated with increased NCCP severity. By controlling the disease and managing related pain earlier, more coherent treatment strategies can be implemented, ultimately improving patients’ quality of life. https://arya.mui.ac.ir/article_32874_561eaa108c9074d4c16da3186f2b9be0.pdf