Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 18 1 2022 01 01 Comparing outcomes of clonidine and captopril in patients with hypertensive urgency: A randomized clinical trial 1 6 31218 10.48305/arya.v18i1.2146 EN Ahmad Mirdamadi Associate Professor, Department of Cardiology, Najafabad Branch, Islamic Azad University, Isfahan, Iran 0000-0002-3120-1812 Raana Abrishamkar Medical Practitioner, Najafabad Branch, Islamic Azad University, Isfahan, Iran 0000-0002-0346-3567 Afrooz Kargaran Medical Practitioner, Najafabad Branch, Islamic Azad University, Isfahan, Iran 0000-0003-2430-3439 Journal Article 2020 03 29  <strong>BACKGROUND: </strong>Hypertension (HTN) is the second leading risk factor for death and disability.<br />One fourth of healthcare in Eastern Europe and Central Asia is being spent on blood pressure<br />(BP)-related diseases. An important situation in patients with high BP is hypertensive crisis<br />(BP > 180/120 mmHg), which is divided to hypertensive emergency and urgency. Therefore,<br />here, we decided to compare the effect of captopril and clonidine in patients with hypertensive<br />urgencies, and their side effects.<br /><strong>METHODS: </strong>This was a parallel-group randomized clinical trial. Patients, who referred to<br />emergency ward with any symptoms of hypertensive crisis, underwent a careful history taking<br />and clinical examination. Individuals with systolic BP (SBP) ≥ 180 mmHg or diastolic BP (DBP)<br />≥ 110 mmHg with no evidence of end organ damage were randomly assigned into two<br />interventions, clonidine and captopril. 25% decrease in BP was considered as ideal relief.<br /><strong>RESULTS: </strong>Regarding the duration of response to treatment drugs, patients who received<br />clonidine relieved significantly faster than those who received captopril (P = 0.016). Moreover,<br />the frequencies of side effects such as headache, dizziness/vertigo, dry mouth, and drowsiness in<br />the clonidine group were significantly lower than captopril group (P < 0.05).<br /><strong>CONCLUSION: </strong>Patients in clonidine group relieved sooner and experienced fewer side effects.<br />Therefore, this study suggests clonidine as a more effective therapeutic for hypertensive urgency<br />compared with captopril. https://arya.mui.ac.ir/article_31218_b5026aa7758dc0e6f85ddb75f754ed14.pdf