Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 15 5 2019 11 03 Interleukin 10, lipid profile, vitamin D, selenium, metabolic syndrome, and serum antioxidant capacity in elderly people with and without cardiovascular disease: Amirkola health and ageing project cohort-based study 233 240 10701 10.22122/arya.v15i5.1623 EN Hamid Reza Nematollahi Department of Biochemistry, School of Sciences, Payame Noor University of Mashhad, Mashhad, Iran 0000-0003-0564-7711 Reza Hosseini Professor, Social Determinants of Health Research Center AND Department of Community Medicine, Babol University of Medical Sciences, Babol, Iran Ali Bijani Assistant Professor, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Haleh Akhavan-Niaki Professor, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Hadi Parsian Professor, Department of Biochemistry, School of Sciences, Babol University of Medical Sciences, Babol, Iran Mahdi Pouramir Professor, Department of Biochemistry, School of Sciences, Babol University of Medical Sciences, Babol, Iran Mehrdad Saravi Associate Professor, Department of Cardiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Mojgan Bagherzadeh Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Abbas Mosapour PhD Candidate, Department of Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran Massud Saleh-Moghaddam Professor, Department of Biochemistry, School of Sciences, Payame Noor University of Mashhad, Mashhad, Iran Majid Rajabian Professor, Department of Biochemistry, School of Sciences, Payame Noor University of Mashhad, Mashhad, Iran Monireh Golpour PhD Candidate, Cellular and Molecular Biology Research Center AND Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Amrollah Mostafazadeh Associate Professor, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran 0000-0003-3178-9203 Journal Article 2017 05 14 BACKGROUND: The age-related autoinflammation-mediated atherosclerosis is associated with some immunological, nutritional, and metabolic parameters and redox status. Here, we evaluated the association of circulatory interleukin 10 (IL-10) levels with lipid profile, some nutrients, and total anti-oxidant capacity in elderly people who presented cardiovascular disease (CVD) with or without metabolic syndrome (MetS) and in healthy subjects.METHODS: In this cross-sectional case-control study, 258 sera prepared from elderly people (144 healthy and 114 patient subjects) who participated in a community-based study, the Amirkola Health and Ageing Project (AHAP), were analyzed for IL-10, lipid profile, vitamin D, selenium (Se), antioxidant capacity, and MetS.RESULTS: Compared to patients, the healthy subjects exhibited higher levels of circulatory IL-10 among individuals with detectable serum IL-10 (P = 0.036). However, this difference was not observed when total subjects from both groups were compared, since more than 90% of those people were IL-10-negative. Se, vitamin D, and antioxidant levels were similar in both groups. There was a negative association between IL-10 and body mass index (BMI) (P < 0.050) and an equivocal association with vitamin D levels, whereas the association between IL-10 and other indicated variables was not significant. Significant association was observed between MetS and CVD prevalence (P < 0.001). There was a positive correlation between Se and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) (P < 0.010) in healthy subjects and with TC in patients (P < 0.050).CONCLUSION: A major proportion of elderly people were serum IL-10-negative, whereas independently to IL-10, MetS was most common in patients with CVD. Weight loss may have the potential to increase IL-10 levels in the elderly. https://arya.mui.ac.ir/article_10701_33f2481179ad598a2b87005cec4b6830.pdf