Cardiovascular research institute, Isfahan University of Medical Sciences ARYA Atherosclerosis Journal 1735-3955 3 3 2010 12 08 THE EFFECT OF VITAMIN E SUPPLEMENTATION ON LIPID PROFILE AND OXIDATIVE STRESS MARKERS IN HEMODIALYSIS PATIENTS 10099 EN Seyyed Gholamreza Mortzzavimoghaddam MD, Department of Internal Medicine, Vali-e-asr Hospital, Birjand University of Medical Sciences, Birjand, Iran. Asghar Zarban PhD, Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Mohammadreza Rezvani MD, Department of Internal Medicine, Vali-e-asr Hospital, Birjand University of Medical Sciences, Birjand, Iran. Journal Article 2010 12 04 Abstract INTRODUCTION: Dyslipidemia and oxidative stress are thought to be important mechanisms in pathogenesis of disease in hemodialysis patients. This study was designed to investigate the efficacy of oral vitamin E supplementation on lipid profile and oxidative stress in hemodialysis patients. METHODS: The study group consisted of 26 uremic patients (10 women and 16 men), 16-68 years of age undergoing maintenance hemodialysis three times a week (12 hours/week), lasting a range of 6-108 months, at Vali-e-Asre Hospital in Birjand (Iran). Total Antioxidant Capacity (TAC), lipid peroxidation, cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein levels were determined before and after oral vitamin E supplementation, 400 mg/d for 90 days. RESULTS: Vitamin E supplementation caused a significant decrease in ThioBarbituric Acid Reactive Substances (TBARS) level as a marker for lipid peroxidation (2.97±0.52 vs. 2.55±0.44, P<0.001) and a significant increase in plasma TAC (1252±348 vs. 1398±372, P<0.01). Although there was a decrease in the level of lipid profile, there were no statistically significant differences in the means of cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein before and after vitamin E supplementation among patients. CONCLUSION: Our results indicated that oral vitamin E supplementation might be able to modify oxidative stress by an increase in TAC, and a decrease in lipid peroxidation; that could be considered as a preventive strategy in hemodialysis patients         Keywords: Antioxidant capacity, lipid peroxidation, lipid profile, vitamin E, hemodialysis.   https://arya.mui.ac.ir/article_10099_995ca733e3657ff9f5f3c823d73371e1.pdf