TY - JOUR ID - 30932 TI - Fibrinolytic Therapy in Thrombosis of Mechanical Valves: Outcomes and Complications JO - ARYA Atherosclerosis Journal JA - ARYA LA - en SN - 1735-3955 AU - Nasri Nasrabadi, Ali AU - Yarhamadi, Fahime AU - Amirpour, Afshin AU - Zavar, Reihane AU - Akbari, Mojtaba AD - Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran AD - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran AD - Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Cardiology ,Chamran Cardiovascular and Medical Research Hospital, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2023 PY - 2023 VL - 19 IS - 5 SP - 213 EP - 219 KW - Prosthetic valve thrombosis KW - Fibrinolytic therapy KW - Streptokinase KW - Reteplase DO - 10.48305/arya.2023.26569.2804 N2 - INTRODUCTION: Valvular heart disease presents a significant and escalating global health challenge. Prosthetic valve thrombosis (PVT) following surgical valve replacement is a primary cause of valve failure. The aim of this study was to ascertain the outcomes and complications of fibrinolytic therapy in patients diagnosed with PVT.METHOD: This cross-sectional study enrolled 81 patients diagnosed with PVT who underwent fibrinolytic therapy between 2008 and 2018. Streptokinase was administered to 87.6% of patients, while 12.4% received reteplase. All demographic and clinical data were gathered from the patients’ medical records. The incidence of successful recovery and complications were assessed.RESULTS: The records of 81 patients (43.2% male, mean age: 51.6 ± 13.9 years) were examined. The findings revealed that 59% and 35% of the patients had mitral and aortic PVT, respectively. While 12% of the patients experienced drug complications, 90% achieved successful recovery. Stroke and severe hemorrhage were complications frequently reported by the patients treated with streptokinase (8% and 4% respectively). The patients treated with reteplase demonstrated a 100% recovery rate. Conversely, 89% of the patients treated with streptokinase achieved successful recovery, and 7% of the patients experienced a partial recovery.CONCLUSION: Fibrinolytic agents can serve as an effective treatment with an excellent success rate for managing PVT in patients post-surgical valve replacement.  UR - https://arya.mui.ac.ir/article_30932.html L1 - https://arya.mui.ac.ir/article_30932_6d3f5f4687f002a3c59d63c93b54fce7.pdf ER -