TY - JOUR ID - 10786 TI - Troponin is a useful marker in clinical decision making in hospitalized patients with COVID-19 infections JO - ARYA Atherosclerosis Journal JA - ARYA LA - en SN - 1735-3955 AU - Safarnezhad-Tameshkel, Fahimeh AU - Motamed, Nima AU - Karbalaie-Niya, Mohammad Hadi AU - Perumal, Dhayaneethie AU - Rezaie, Nader AU - Izadi, Shirin AU - Ranjbar, Mitra AU - Yadollahzadeh, Mahdi AU - Behdad, Behnam AU - Hemmasi, Gholamreza AU - Kaveh, Vahid AU - Anoushirvani, Ali Arash AU - Malek, Mojtaba AU - Farahani, Behzad AU - Eskandari, Ramin AU - Panahi, Mahshid AU - Rahimi, Mandana AU - Emami, Sepideh AU - Zamani, Farhad AU - Farrokhpour, Mohsen AD - Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran AD - Associate Professor, Department of Social Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran AD - Assistant Professor, Gastrointestinal and Liver Diseases Research Center AND Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran AD - Assistant Professor, School of Science, Engineering and Computing, Kingston University, Kingston, United Kingdom AD - Associate Professor, Department of Pulmonology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran AD - Assistant Professor, Department of Pulmonology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran AD - Professor, Department of Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran AD - Assistant Professor, Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran AD - Resident, Department of Internal Medicine, School of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran AD - Associate Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran AD - Assistant Professor, Department of Hematology and Medical Oncology, School of Medicine, Iran University Medical Sciences, Tehran, Iran AD - Associate Professor, Department of Interventional Radiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran AD - Associate Professor, Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran AD - Assistant Professor, Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran AD - Assistant Professor, Department of Pathology, Iran University of Medical Sciences, Tehran, Iran AD - Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran Y1 - 2022 PY - 2022 VL - 17 IS - 1 SP - 1 EP - 7 KW - Troponin KW - COVID-19 KW - Mortality DO - 10.22122/arya.v17i0.2191 N2 - BACKGROUND: COVID-19 was introduced by the World Health Organization (WHO) as a global pandemic. The spectrum of symptoms of the disease ranges from a mild cold to death. It has a higher mortality rate in people with a history of comorbidities, including cardiovascular disease (CVD) and can also contribute to cardiac injury. This study was conducted to evaluate the relationship between troponin levels as a cardiac marker and adverse outcomes in this disease.METHODS: The study sample included 438 patients hospitalized with COVID-19; however, the troponin data of 6 patients were not available. The need to be admitted to the intensive care unit (ICU), and death were considered the adverse outcome in patients with COVID-19. Troponin levels were checked in all patients on day 1 and day 3 of hospitalization. Multiple logistic regression analysis was performed to determine whether there was an independent association between the adverse outcomes and troponin enzyme in hospitalized patients with COVID-19.RESULTS: The mean age of patients was 61.29 ± 15.84 years. Among the 432 patients tested on day 1 of hospitalization, 24 patients (5.6%) tested positive (Troponin 1), and among the 303 patients tested on day 3, 13 patients (4.3%) tested positive (Troponin 2). Based on our results, Troponin 1 showed an independent association with both death (3.008 [95%CI = 1.091-8.290]; P = 0.033) and need for ICU admission (8.499 [95%CI = 3.316-21.788]; P < 0.001) in multiple logistic regression analysis. Moreover, the status of Troponin 2 had an independent significant association with both death (4.159 [95%CI = 1.156-14.961]; P = 0.029) and ICU admission (7.796 [95%CI = 1.954-31.097]; P = 0.004).CONCLUSION: Troponin showed a significant association with adverse outcomes in people who were hospitalized with COVID-19. The serial assessment of this enzyme from the time of hospitalization may improve the clinical decision making of clinicians. UR - https://arya.mui.ac.ir/article_10786.html L1 - https://arya.mui.ac.ir/article_10786_4a4618c3404aa580d2152d5980b3ba73.pdf ER -