TY - JOUR ID - 10385 TI - Pivotal role of microRNA-33 in metabolic syndrome: A systematic review JO - ARYA Atherosclerosis Journal JA - ARYA LA - en SN - 1735-3955 AU - Gharipour, Mojgan AU - Sadeghi, Masoumeh AD - PhD Candidate, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran AD - Associate Professor, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2013 PY - 2013 VL - 9 IS - 6 SP - 372 EP - 376 DO - N2 - Metabolic syndrome (MetS) is a major public health concerns and increase in the incidence of MetS caused a rise in the rates of global morbidity, and mortality due to cardiovascular disease and diabetes. Lifestyle modification, a healthy diet, and pharmacological treatment and bariatric surgery are recommended in order to control this syndrome. Molecular mechanisms of metabolic disorders are essential in order to develop novel, valid therapeutic strategies. MicroRNA-33 plays imperative regulatory roles in a variety of biological processes including collaboration with sterol regulatory element-binding protein (SREBP) to maintain cholesterol homeostasis, high-density lipoprotein formation, fatty acid oxidation, and insulin signaling. Investigation of these molecules and their genetic targets may potentially identify new pathways involved in complex metabolic disease processes, improve our understanding of metabolic disorders, and influence future approaches to the treatment of obesity. This article reviews the role of miRNA-33 in metabolic syndrome, and highlights the potential of using miRNA-33 as a novel biomarker and therapeutic target for this syndrome.   Keywords: MicroRNA-33, Insulin Resistance Syndrome X, Regulatory Role  UR - https://arya.mui.ac.ir/article_10385.html L1 - https://arya.mui.ac.ir/article_10385_eaa2f1c20e8a01de2e97f77c65915356.pdf ER -