TY - JOUR ID - 10248 TI - Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits JO - ARYA Atherosclerosis Journal JA - ARYA LA - en SN - 1735-3955 AU - Asgary, Sedighe AU - Najafi, Somayeh AU - Ghannadi, Alireza AU - Dashti, Gholamreza AU - Helalat, Alireza AD - Professor, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. AD - MSc, Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Professor of Pharmacognosy, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Associate Professor, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. AD - PhD, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Y1 - 2012 PY - 2012 VL - 7 IS - 4 SP - 146 EP - 150 DO - N2 - BACKGROUND: Hypercholesterolemia is among the most common health problems treated withtraditional remedies. Nigella sativa (NS) is an effective plant for treating hypercholesterolemia.However, the effects of this herb on hematologic factors and hemostasis system have not beenelucidated. This study was designed to investigate the effects of NS on these factors in bothnormal and hypercholesterolemic rabbits.METHODS: In this research, twenty rabbits were randomly distributed into four groups of five. Thegroups received four different diets, namely normal, normal + NS (5%), hypercholesterolemic (1٪cholesterol), and hypercholesterolemic (1٪ cholesterol) + NS (5%), for 8 weeks. After this period,WBC (white blood cell), RBC (red blood cell), HTC (hematocrit), HGB (hemoglobin content), PLT(platelet), fibrinogen (FIB) and factors VII (F VII) were measured.RESULTS: Using NS significantly increased PLT count in the normal group. In addition, it significantlydecreased WBC counts in the hypercholesterolemic group (P < 0.05). However, dietaryuse of NS did not have any effects on other hematologic factors including RBC, HTC, HGB, FIB,and F VII (P < 0.05).CONCLUSION: Increased PLT numbers might cause enhanced coagulation. The achieved resultscall for more research on the effects of various diets (hypercholesterolemic and normal diet)supplemented with NS on different coagulation factors and hemostasis system.Keywords: Hematological Factors, Hypercholesterolemia, Nigella Sativa L., Rabbit. UR - https://arya.mui.ac.ir/article_10248.html L1 - https://arya.mui.ac.ir/article_10248_691a80bc959dd3c1c71ab9ada0226ca2.pdf ER -