TY - JOUR ID - 10111 TI - EFFECTS OF EICOSAPENTAENOIC ACID AND VITAMIN E SUPPLEMENTATION ON SERUM LIPID PROFILE, BLOOD PRESSURE, ANTIOXIDANT STATUS AND INFLAMMATORY RESPONSES IN MALE ATHLETES JO - ARYA Atherosclerosis Journal JA - ARYA LA - en SN - 1735-3955 AU - Ghiasvand, Reza AU - Djazayery, Seyed Abolghassem AU - Djalali, Mahmoud AU - Keshavarz, Seyed Ali AU - Hosseini, Mostafa AD - M.Sc., Dept. of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences (TUMS), Tehran. AD - Ph.D. Professor Institute of Public Health Research, TUMS, 14155-6446 Poursina Street, Qods Street, Tehran, Iran. AD - Ph.D., D.Sc. Dept. of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, TUMS, Tehran, Iran. AD - Ph.D., Dept. of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, TUMS, Tehran, Iran. AD - Ph.D., Dept. of Biostatistics and Epidemiology, School of Public Health and Institute of Public Health Research, TUMS, Tehran, Iran. Y1 - 2010 PY - 2010 VL - 3 IS - 2 SP - EP - DO - N2 -   Abstract INTRODUCTION: The relationship between ω -3 fatty acids and surrogate circulating markers of cardiovascular disease (CVD) risk, especially in healthy individuals remains to be determined. We investigated the effects of Eicosapentaenoic acid (EPA) supplementation, with or without vitamin E, on serum lipid profile, C-reactive protein (CRP), blood pressure (BP) and total antioxidant capacity in a sample of male athletes. methods: This randomized double blind placebo-controlled clinical trial was conducted in 2006 on 34 apparently healthy, well-trained male basketball players, aged 17-35 years, . Venous blood samples were obtained between 5:00 and 6:00 p.m., after exercising for 2 hours, at the baseline and after intervention. Participants received 2 g EPA and/or 400 IU vitamin E and/or placebo depending on their groups. For 6 weeks, eight subjects received an EPA supplement with vitamin E (group 1), nine subjects received an EPA supplement with vitamin E placebo (group 2), nine subjects received an EPA supplement placebo and vitamin E (group 3), and eight subjects received an EPA supplement placebo and vitamin E placebo (group 4). results: Significant decreases were documented in the serum levels of total cholesterol (TC), triglycerides ( TG), LDL-C and CRP in group1 (p<0.01), in TC, TG, LDL-C, CRP, and BP in group 2 (p<0.01), and significant increase in total antioxidant capacity in group 3 (P<0.05). No significant difference was found in LDL between groups 1 and 4 (P<0.05), and in total antioxidant capacity between groups 2 and 3 (p<0.001) and groups 3 and 4 (p<0.001), and in CRP level between groups 2 and 3 (P<0.05). There were no significant differences in TC, TG, HDL-C and BP between the groups after 6 weeks of intervention. CONCLUSIONS: Six weeks of EPA+ vitamin E supplementation improved the lipid profile and reduced the CRP level, whereas six weeks of EPA supplementation without vitamin E improved the lipid profile, but increased CRP and BP. Six weeks of vitamin E supplementation alone increased total plasma antioxidant capacity.     Keywords: Eicosapentaenoic acid, vitamin E, lipid, antioxidant, inflammation, healthy men, exercise. UR - https://arya.mui.ac.ir/article_10111.html L1 - https://arya.mui.ac.ir/article_10111_c6dd80a81fc7e2ee4853142a73c66201.pdf ER -