Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
05
01
Evaluation of haptoglobin genotypes in patients with metabolic syndrome: A preliminary report
167
172
EN
Alireza
Nakhaee
Associate Professor, Cellular and Molecular Research Center AND Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Mohammad
Hashemi
Professor, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
hashemim@zaums.ac.ir
Alireza
Rezaeifar
Lecturer, Department of Clinical Biochemistry, Zabol University of Medical Sciences, Zabol, Iran
Mahmoud Ali
Kaykhaei
Assistant Professor, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
BACKGROUND: Haptoglobin (Hp) polymorphisms have been suggested to be associated with many pathological conditions, including cardiovascular diseases, infectious diseases, and type 2 diabetes. For the first time, we aimed to investigate the possible association between Hp genotypes and metabolic syndrome (MES) in a sample of Iranian subjects. METHODS: In this study, 291 patients with MES according to National Cholesterol Education Program-Adult Treatment Panel III criteria, and 284 healthy individuals have been studied. We determined Hp genotype by polymerase chain reaction. RESULTS: The frequency of three genotype (Hp1-1, Hp2-1, and Hp2-2) in healthy individuals and patients were 7.74, 39.7, 52.46, and 7.9, 31.61, 60.48 percent, respectively. There was no significant difference between the groups regarding Hp genotypes. The Hp2 allele was the predominant allele in MES (76.29%) and normal subjects (72.54%). CONCLUSION: Hp polymorphisms are not risk factor for predisposition to MES in a sample of the Iranian population. Further studies with different ethnicities are required to validate our findings.
Haptoglobin,Phenotype,Metabolic Syndrome
https://arya.mui.ac.ir/article_10468.html
https://arya.mui.ac.ir/article_10468_5c83c5cffc575434728e542d11ee5244.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
05
24
A study of the efficacy of furosemide as a prophylaxis of acute renal failure in coronary artery bypass grafting patients: A clinical trial
173
178
EN
Fatemeh
Bayat
Assistant Professor, Fellowship in Cardiac Anesthesiology, Alborz University of Medical Sciences, Tehran, Iran
alidabbagh@yahoo.com
Zahra
Faritous
Associate Professor, Fellowship in Cardiac Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Nahid
Aghdaei
Associate Professor, Fellowship in Cardiac Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Ali
Dabbagh
Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
alidabbagh@sbmu.ac.ir
BACKGROUND: Renal failure is a frequent event after coronary artery bypass grafting (CABG). Hemodynamic alterations during surgery as well as the underlying disease are the predisposing factors. We aimed to study intermittent furosemide therapy in the prevention of renal failure in patients undergoing CABG. METHODS: In a single-blind randomized controlled trial, 123 elective CABG patients, 18-75 years, entered the study. Clearance of creatinine, urea and water were measured. Patients were randomly assigned into three groups: furosemide in prime (0.3-0.4 mg/kg); intermittent furosemide during CABG (0.2 mg/kg, if there was a decrease in urinary excretion) and control (no furosemide). RESULTS: There was a significant change in serum urea, sodium and fluid balance in “intermittent furosemide” group; other variables did not change significantly before or after the operation. Post-operative fluid balance was significantly higher in “intermittent furosemide” group (2573 ± 205 ml) compared to control (1574 ± 155 ml) (P < 0.010); also, fluid balance was higher in “intermittent furosemide” group (2573 ± 205 ml) compared to “furosemide in prime” group (1935 ± 169 ml) (P < 0.010). CONCLUSION: The study demonstrated no benefit from intermittent furosemide in elective CABG compared to furosemide in prime volume or even placebo.
Renal Failure,Coronary Artery Bypass Grafting,Furosemide
https://arya.mui.ac.ir/article_10469.html
https://arya.mui.ac.ir/article_10469_cba7e6046e2b7f80607606c914529b90.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
05
01
Applying the Framingham risk score for prediction of metabolic syndrome: The Kerman Coronary Artery Disease Risk Study, Iran
179
185
EN
Gholamreza
Yousefzadeh
Physiology Research Center, Institute of Nouropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Mostafa
Shokoohi
Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
shokouhi.mostafa@gmail.com
Hamid
Najafipour
Physiology Research Center, Institute of Nouropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Mitra
Shadkamfarokhi
Physiology Research Center, Institute of Nouropharmacology, Kerman University of Medical Sciences, Kerman, Iran
BACKGROUND: There has been a few studies about the predictability of metabolic syndrome (MetS) based on the Framingham risk score (FRS) as a tool for predicting the risk of 10-years cardiovascular diseases (CVD) in Iranian population. The aim of this study was to compare the risk stratification obtained with the FRS and MetS in a cohort of the Iranian population. METHODS: In this population-based study Kerman Coronary Artery Disease Risk study, Iran, MetS was diagnosed as defined by the revised National Cholesterol Education Program definition criteria (ATPIII) and the FRS was calculated using a computer program, previously reported algorithm. RESULTS: Overall, the prevalence 10-years risk of CVD for patients with MetS was significantly different with those without MetS (74.3 vs. 86.4% for low-risk patients, 18.1 vs. 12.3% for intermediate-risk people, and 7.6 vs. 1.3% for high-risk individuals) (P < 0.001). The frequency of intermediate-risk and high-risk for 10-year CVD in men with MetS (39.5 and 18.3%, respectively) was considerably higher than women with MetS (3.2 and 0.1%, respectively). Using multiple logistic regression, the odds ratio of MetS in intermediate-risk and high-risk FRS group was 1.7 and 6.7, respectively (P < 0.001). CONCLUSION: Significant association between the presence of MetS and high risk for CVD based on FRS was revealed in both men and women indicating a good concordance between MetS and FRS in predicting the risk of CVDs. However, the odds ratio of the development of risk of cardiovascular events among women was higher than men with MetS.
Metabolic Syndrome,Framingham Risk Score,Cardiovascular Disease,Ischemic Heart Disease
https://arya.mui.ac.ir/article_10470.html
https://arya.mui.ac.ir/article_10470_5a7914a85772a85983db38290fe92495.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
05
24
Effects of single antegrade hot shot in comparison with no hot shot administration during coronary artery bypass grafting
186
190
EN
Pouya
Mirmohammadsadeghi
Student of Medicine, Isfahan Medical Students Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
pouyammsadeghi@gmail.com
Mohsen
Mirmohammadsadeghi
Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical
Sciences, Isfahan, Iran
BACKGROUND: Superior results will be achieved from cardiac surgery by minimizing the effect of ischemia/reperfusion injury during cross-clamping of the aorta. Different cardioplegia solutions have been introduced, but the optimum one is still ambiguous. The aim of this study is to determine the effect of single antegrade hot shot terminal warm blood cardioplegia (TWBC) on patients who had undergone coronary artery bypass grafting (CABG). METHODS: In total, 2488 patients who had CABG surgery in Sina Hospital, Isfahan, Iran, from 2003 to 2011 were enrolled in this case-control study. They were divided into two groups, those who received cold cardioplegia only and those who received a hot shot following cold cardioplegia. Demographics, and clinical data, such as; premature atrial contraction (PAC) arrhythmia, diabetes treatment, and left ventricular ejection fraction (EF), were collected and logistic regression analysis was used to analyze the data. RESULTS: There were significant differences found between subjects receiving antegrade hot shot based on direct current (DC) shocks, with regard to; female, EF levels, diabetes treatment (P < 0.050). Those who did not receive the hot shot and were not diabetic received more DC shock (P = 0.019). The prevalence of subjects who did no need DC shock was significantly higher among male subjects who had good EF and acceptable diabetic treatment. Multiple logistic regression showed that PAC arrhythmia did not have a significant effect on receiving DC shock during CAGB [0.84 (0.25, 2.85), (P = 0.780)]. Having poor EF increased the risk of receiving DC shock among subjects by 2.81 [(1.69, 4.69), (P ≤ 0.001)] (P < 0.001). Among the diabetic subjects, receiving insulin decreased the risk of receiving DC shock by 0.54 (0.29, 0.98) (P = 0.042). CONCLUSION: It was concluded that single antegrade hot shot following cold cardioplegia was not particularly effective in the CABG group. TWBC will decrease the need for DC shock.
Coronary Artery Bypass,Heart Arrest,Induced,Stroke,Mortality,Oxidative Stress,Reperfusion Injury
https://arya.mui.ac.ir/article_10471.html
https://arya.mui.ac.ir/article_10471_fcfab54d12802fe6277596b2893fbf61.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
06
28
Adiponectin inhibits oxidized low density lipoprotein-induced increase in matrix metalloproteinase 9 expression in vascular smooth muscle cells
191
195
EN
Maryam
Saneipour
MSc Student, Clinical Biochemistry Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
Keihan
Ghatreh-Samani
0000-0001-8993-0527
Assistant Professor, Clinical Biochemistry Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
kgsamani@yahoo.com
Esfandiar
Heydarian
Associate Professor, Clinical Biochemistry Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
Effat
Farrokhi
0000-0002-3068-0719
PhD Candidate, Cellular and Molecular Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
Narges
Abdian
PhD Candidate, Cellular and Molecular Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
BACKGROUND: High expression of matrix metalloproteinase 9 (MMP9) during vascular injury and inflammation plays an important role in atherosclerotic plaque formation and rupture. In the process of atherosclerosis, oxidized low-density lipoprotein (oxLDL) upregulates MMP9 in human aortic vascular smooth muscle cells (HA/VSMCs). Adiponectin is an adipose tissue-derived hormone that has been shown to exert anti-atherogenic and anti-inflammatory effects. The aim of this study was to investigate the effect of adiponectin on MMP9 expression under pathogenic condition created by oxLDL in HA/VSMCs. METHODS: In this experimental study, HA/VSMC were stimulated with oxLDL alone and in the presence of adiponectin for 24 and 48 h. The expression of MMP9 gene was determined by real-time polymerase chain reaction method. The protein level of this gene was investigated by western blotting technique. RESULTS: An oxLDL increased MMP9 expression 2.16 ± 0.24- and 3.32 ± 0.25-fold after 24 and 48 h, respectively and adiponectin decreased oxLDL-induced MMP9 expression in a time-dependent manner. CONCLUSION: These results show that adiponectin changes extracellular matrix by reducing MMP9 mRNA and protein, therefore, may stabilize lesions and reduce atheroma rupture.
Matrix Metalloproteinase 9,Adiponectin,Oxidized Low Density Lipoprotein
https://arya.mui.ac.ir/article_10472.html
https://arya.mui.ac.ir/article_10472_dad76b5cacaaca31ae06c492e28fddd8.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
05
01
Effects of citalopram on heart rate variability in women with generalized anxiety disorder
196
203
EN
Fatemeh
Ranjbar
Associate Professor, Clinical Psychiatry Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Fariborz
Akbarzadeh
Associate Professor, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
f_akbarzadeh@yahoo.com
Faramarz
Zakeri
Resident, Clinical Psychiatry Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mostafa
Farahbakhsh
Resident, Clinical Psychiatry Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Ali
Nazari
Assistant Professor, Department of Psychology, School of psychology, University of Tabriz, Tabriz, Iran
BACKGROUND: Heart rate variability (HRV) is defined as variations in R-R interval with time. Dysautonomia is common in patients with psychiatric disorders such as depression and anxiety. Using HRV analysis, recent studies showed that in anxiety disorders, the vagal cardiac function decreases, and sympathetic function increases. This study aimed at investigating citalopram effects on HRV. METHODS: This before and after study was conducted in 25 generalized anxiety disorder (GAD) patients. GAD was diagnosed based on clinical interview according to diagnostic and statistical manual of mental disorders IV-Text revised (DSM-IV-TR) criteria using Structured Clinical Interview for DSM Disorders-I questionnaire. A cardiologist studied 24 h ambulatory monitoring of the electrocardiogram (Holter) on all patients before the treatment. A volume of 20 mg of citalopram was administered to the subjects on a daily basis. Then, they were studied by Holter monitoring again after 1-month of administration of citalopram. RESULTS: The average age of participants was 35.32 ± 8.7. The average Holter monitoring time was 23.29 ± 1.14 h before treatment and 23.81 ± 0.68 after it. The 3 h low frequency/high frequency ratio was significantly different between 3 h segments of time before treatment (P < 0.001). This difference was even higher after treatment (P = 0.001). Data showed an increase in parasympathetic tone during sleep both before and after treatment. CONCLUSION: These patients showed some impairments of HRV indices that did not improve by citalopram in future, the clinical importance of such disturbances should be evaluated in details with prolonged follow-up and greater sample size.
Anxiety disorders,Heart Rate,Ambulatory electrocardiography
https://arya.mui.ac.ir/article_10473.html
https://arya.mui.ac.ir/article_10473_686f0517d0ad857d5a15722dbb05f144.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
05
24
Percutaneous aortic valve implantation in bicuspid aortic valve: A case report
204
207
EN
Seyed Ebrahim
Kassaian
Tehran Heart Center AND Department of Interventional Cardiology, Tehran University of Medical Sciences, Tehran, Iran
ekassaian@yahoo.com
Faramarz
Fallahi
Department of Cardiology, Mostafa Khomaini Hospital, Shahed University, Tehran, Iran
fallahi@shahed.ac.ir
Mahmood
Shirzad
Tehran Heart Center AND Department of Cardiac Surgery, Tehran University of Medical Sciences, Tehran, Iran
Mohammad
Sahebjam
Tehran Heart Center AND Department of Echocardiography, Tehran University of Medical Sciences, Tehran, Iran
Mojtaba
Salarifar
Tehran Heart Center AND Department of Echocardiography, Tehran University of Medical Sciences, Tehran, Iran
BACKGROUND: Transcatheter aortic valve implantation (TAVI) was known as an alternative technique for treatment of severe aortic stenosis (AS). This technique is controversial in bicuspid aortic valve (BAV). Here, we report TAVI for severe AS in a BAV setting in a patient with serious lung disease. CASE REPORT: A 68-year-old woman with a history of coronary artery bypass graft, BAV and severe AS, asthma, who had repeatedly denied any suggestion for open heart surgery, was our volunteer candidate for TAVI. The peak and mean pressure gradient decreased from 53 and 43 mm Hg to 13and 6 mm Hg respectively. CONCLUSION: TAVI could be a viable option for highly selected patients with AS and BAV who have a prohibitive risk for open heart surgery.
Transcatheter Aortic Valve Implantation,Aortic Stenosis,Bicuspid Aortic Valve
https://arya.mui.ac.ir/article_10474.html
https://arya.mui.ac.ir/article_10474_af314cdb7a906e43a4dd8461dd4573eb.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
05
24
Surgical embolectomy in the management of massive and sub-massive pulmonary embolism: The results of 30 consecutive ill patients
208
213
EN
Ali
Azari
Cardiovascular Research Center, Ghaem Hospital AND Atherosclerosis Prevention Research Center, Imam Reza Hospital, AND Department of Cardiac Surgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Leila
Bigdelu
0000-0002-9372-781X
Cardiovascular Research Center, Ghaem Hospital AND Atherosclerosis Prevention Research Center, Imam Reza Hospital AND Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
bigdelul@mums.ac.ir
Zahra
Moravvej
Cardiovascular Research Center, Ghaem Hospital AND Atherosclerosis Prevention Research Center, Imam Reza Hospital AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
BACKGROUND: Despite the improvement in the diagnosis and treatment of acute pulmonary embolism, it is yet a common clinical problem. The actual role of open embolectomy has not been well understood. The present report aimed to extrapolate the outcome of early open pulmonary embolectomy in a number of patients with acute (sub) massive pulmonary embolism (AMPE/ASMPE). METHODS: A prospective study was performed on 30 patients who underwent emergency embolectomy at Ghaem Hospital, Mashhad, Iran during January 2005 to November 2012. All patients with an indication for pulmonary embolectomy according to recent American Heart Association guideline were enrolled in this study. Echocardiographic features, pulmonary artery pressure, and right ventricular (RV) diameter were recorded. The patients were followed up monthly by two cardiologists. RESULTS: Indications for operation in descending order consisted of contraindication for fibrinolytic therapy (30%), failure to respond to fibrinolysis (26.66%), cardiopulmonary arrest (20%), patent foramen ovale (20%), right atrium clot (10%), and cardiogenic shock (10%). Mean pulmonary artery pressures were 52.26 ± 6.54 and 29.43 ± 2.87 mmHg before and after the operation, respectively (P < 0.0001). RV function and diameter improved significantly after surgery (P < 0.0001 and < 0.0001, respectively). Complete follow-up was performed in all surviving patients. All patients survived the operation, except one who died 2 days after surgery due to profound hypotension. CONCLUSION: Short and long-term outcomes of early open embolectomy seemed to be satisfactory in high-risk patients presenting high clot burden in central pulmonary arteries. This study demonstrated that pulmonary embolectomy may play a promising role in the management of AMPE and ASMPE and recommended for future clinical trials.
Echocardiography,Fibrinolysis,Embolectomy,Thromboembolism,Pulmonary,Treatment Outcome
https://arya.mui.ac.ir/article_10475.html
https://arya.mui.ac.ir/article_10475_74cd8f69e09adc9ce9220720c4ceabe7.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
11
3
2015
05
01
Journal Index
EN
Index
Journal
0000-0002-1825-0097
arya@crc.mui.ac.ir
Click to download the index of this issue.
https://arya.mui.ac.ir/article_10467.html
https://arya.mui.ac.ir/article_10467_8b748fcd34a7b90584591d24d1530fdd.pdf