Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
13
EFFECT OF DIFFERENT PHYSICAL ACTIVITY TRAINING METHODS ON OVERWEIGHT ADOLESCENTS
EN
Shohreh
Ghatrehsamani
Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan
kelishadi@med.mui.ac.ir
Noushin
Khavarian
Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan
Maryam
Beizaei
Research Assistant, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan
Reza
Ramedan
Senior Expert, Isfahan Sport Training Organization, Isfahan
Parinaz
Poursafa
Senior Expert, Isfahan Sport Training Organization, Isfahan
Roya
Kelishadi
Associate Professor of Pediatrics, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan
BACKGROUND: In view of the growing trend of obesity around the world, including in our country, and the effect of reduced physical activity in increasing the incidence of obesity and overweight in children and adolescents and limitations of families in providing transport for their children to attend exercise classes, as well as time limitations of students in taking part in these classes, accessing appropriate methods for presenting physical activity training seems essential. METHODS: This non-pharmacological clinical trial was performed during six months from May to November 2007 on 105 children and adolescents aged 6-18 years with obesity, randomly assigned to 3 groups of thirty-five. Nutrition and treatment behavior were the same in all groups, but physical activity training in the first group was taking part in physical activity training classes twice a week, in the second group by providing a training CD, and in the third group via face-to-face training. Before and after the intervention, anthropometric indicators were measured and recorded. RESULTS: Mean body mass index (BMI) of participants in group attended physical activity training classes, and in the group undergone training with CD, after the interventions was significantly lower than that before the intervention. CONCLUSION: Our findings demonstrated that training using CDs can also be effective in reducing BMI in overweight and obese children and adolescents as much as face-to-face education and participation in physical training classes. Extending such interventions can be effective at the community level. Keywords: Children, adolescents, physical activity, education, obesity, treatment.
https://arya.mui.ac.ir/article_10010.html
https://arya.mui.ac.ir/article_10010_d9def2e067e2e79298d2cc6e17cdacb8.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
13
EVALUATION OF LEPTIN AND ADIPONECTIN LEVELS IN PATIENTS WITH STABLE ANGINA PECTORIS
EN
Masoud
Mozafari
0000-0001-7179-5558
Cardiology Resident, Isfahan University of Medical Sciences, Isfahan
sadeghimasoumeh@gmail.com
Masoumeh
Sadeghi
0000-0001-7179-5558
Associate Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan
Hamid
Sanei
Associate Professor of Cardiology, Isfahan University of Medical Sciences, Isfahan
Mohammad Arash
Ramezani
Community Medicine Specialist, Isfahan Cardiovascular Research Center, Isfahan
Allahyar
Golabchi
Cardiology Resident, Isfahan University of Medical Sciences, Isfahan
Nizal
Sarrafzadegan
Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences Isfahan
BACKGROUND: Leptin and adiponectin are two adipose tissue hormones and their association with the incidence of cardiovascular diseases is under evaluation. The aim of this study was to determine the relationship of leptin and adiponectin with coronary artery diseases. METHODS: One hundred and seventy patients with angina pectoris and indications of coronary angiography underwent angiography. Serum levels of blood lipids, leptin, and adiponectin were measured. The gathered data was evaluated using SPSS software, V. 15, by multivariate variance analysis. RESULTS: Analysis of the data demonstrated that 45.1% of the patients had positive angiographic findings. The serum levels of leptin and adiponectin were significantly lower than the minimum levels specified by the kit. However, the two groups, i.e., patients with positive angiographic findings and those with negative findings were not significantly different according to the serum levels of the hormones. Moreover, no significant correlation between the serum levels of the hormones and serum lipids was observed. CONCLUSION: Various studies have demonstrated that high serum level of leptin and the incidence of coronary artery diseases are correlated. On the other hand, they have reported that adiponectin has cardioprotective role. Confirmation of these findings requires more detailed studies. Keywords: Leptin, Adiponectin, Coronary artery disease
https://arya.mui.ac.ir/article_10014.html
https://arya.mui.ac.ir/article_10014_d4d1361e83d2186aacf70ba706cce8f5.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
01
RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS WITH SOME INFLAMMATORY BIOMARKERS, GHRELIN AND ADIPONECTIN IN IRANIANS WITH AND WITHOUT METABOLIC SYNDROME IN ISFAHAN COHORT STUDY
EN
Taiebeh
Hajmohammadi
0000-0001-7179-5558
Resident of Cardiology, Isfahan University of Medical Sciences
sadeghimasoumeh@gmail.com
Masoumeh
Sadeghi
0000-0001-7179-5558
Associate Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences
Masoumeh
Dashti
Resident of Neurology, Isfahan University of Medical Sciences
Mohammad
Hashemi
Associate Professor of Cardiology, Isfahan University of Medical Sciences
Mohammad
Saadatnia
Associate Professor of Neurology, Isfahan University of Medical Sciences
Mojgan
Soghrati
General Practitoner, Medical Researcher
Mohammad
Talaei
Medical doctor, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences
Nizal
Sarrafzadegan
Professor of Cardiology, Head of Isfahan Cardiovascular Research Center, Isfahan
BACKGROUND: Recent studies have confirmed inflammatory factors and metabolic syndrome (MetS) as important cardiovascular disease (CVD) risk factors. Recently measurement of carotid intima-media thickness (IMT) has been used for evaluation of early atherosclerosis. This study was designed to assess the correlation between IMT with some inflammatory biomarkers, ghrelin and adiponectin in people with and without MetS in a cohort sample in Isfahan province. METHODS: Among participants of Isfahan Cohort Study (ICS) by random sampling, 88 participants were selected and divided into case (with MetS) and control (without MetS) groups. A questionnaire including demographic data and CVD risk factors was completed for all of the participants. Physical examination and blood pressure, height, weight and waist circumference measurements were done for all subjects. Vascular echocardiography was done for evaluation of IMT of each carotid artery of both sides. Interlukin-6 (IL-6), interlukin-10 (IL-10), highly sensitive C-reactive protein (hs-CRP), ghrelin and adiponectin levels were measured using ELIZA method. Data were entered in SPSS version 15 and analyzed by t test, chi square, Pearson correlation and linear regression analyze. RESULTS: The mean waist circumference, BMI, systolic blood pressure, diastolic blood pressure, hs –CRP and IMT of left carotid artery were significantly higher in participants with Mets. There was significant correlation between left carotid IMT and IL-6 level in all patients (P=0.03). After adjustment for age and sex, significant relationship in groups with MetS was only reported between the left IMT and IL-6 (P=0.02). There was no relation between IMT and other inflammatory markers in subjects with and without MetS. CONCLUSION: Significant correlation between IL-6 and IMT was reported in patients with MetS. While no significant correlation between IL-10, adiponectin and ghrelin with IMT was observed in metabolic syndrome group. Keywords: Intima-media thickness (IMT), carotid artery, hs-CRP, Ghrelin, Adiponectin IL-6, IL-10.
https://arya.mui.ac.ir/article_10016.html
https://arya.mui.ac.ir/article_10016_c34f1d31c4104cfacfe3ee5cdf9c4168.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
01
EFFICACY OF GLUCOSE-INSULIN-POTASSIUM INFUSION ON LEFT VENTRICULAR PERFORMANCE IN TYPE II DIABETIC PATIENTS UNDERGOING ELECTIVE CORONARY ARTERY BYPASS GRAFT.DY
EN
Seied Mostafa
Seied-Hosseini
Resident of Cardiology, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
m.seyedhossaini@gmail.com
Ali
Pourmoghadas
Associate Professor of Cardiology, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan,
Omid
Aghadavoudi
Associate Professor of Anesthesiology, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
Masoud
Amini
Professor of Endocrinology, Endocrine and Metabolism Research center, Isfahan University of Medical Sciences, Isfahan
Mohsen
Mirmohammad-Sadeghi
Assistant professor of Surgery, Department of Heart Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan.
Allahyar
Golabchi
Resident of Cardiology, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
Behnood
Hedayatpour
School of Medicine, Isfahan University of Medical Sciences, Isfahan
Elham
Haratian
Isfahan University of Medical Sciences, Isfahan
Narge
Ghaem-Maghami
Isfahan University of Medical Sciences, Isfahan
Laleh
Khanoom Sharegh
Isfahan University of Medical Sciences, Isfahan
BACKGROUND: Glucose-insulin-potassium (GIK) may improve cardiovascular performance after coronary artery bypass graft surgery (CABG). Our study investigated whether an infusion of GIK during elective CABG surgery in type II diabetic patient improved left ventricular performance. METHODS: We measured left ventricular ejection fraction and troponin (Tn), a myofibrillar structural protein. In this research, after ethics committee approval, 50 patients with type 2 diabetes mellitus (DM) were enrolled into a randomized simple sampling, prospective, double-blind clinical trial study. In the case group, 500 cc dextrose water 5% plus 80 IU regular insulin and 40 mEq KCL were infused at the rate of 30 cc/hr. Patients in control group received 5% dextrose solution at the rate of 30cc/hr. Venous blood samples were taken before induction of anesthesia, after removal of the aortic clamp and before discharging from hospital. The Mann-Whitney-test was used to test for differences in Tn concentration between the groups. Fisher’s exact test was used to determine whether there was a difference in the proportion of patients with a low ejection fraction (<45%) in the case group compared with that in the control group. Changes in potassium and glucose concentrations over time within the groups were examined by ANOVA and paired t-tests. P<0.05 was regarded as significant level for all tests. RESULTS: In this study, 50 patients with type 2 DM were evaluated in case and control groups. The mean age ± SD in the case group was 57.7 ±9.9 years and in the other group was 61.2 ± 8.4 years. The groups were well-matched for age, sex and number of bypass grafts. Randomization did not give an equal distribution of male and female patients. There wasn’t any significant difference in ejection fraction between the case and control groups before and after CABG (P>0.05). Tn concentration in the case group was 3.3 ± 5.0 and in the control group was 3.9 ± 5.1. There was no significant difference in Tn between the two groups before and after CABG (P>0.05). There was not any significant difference in hospitalization time between the two groups. CONCLUSION: The results suggested that GIK can’t improve left ventricular performance in routine CABG surgery. Keywords: Cardiovascular surgery, Glucose-Insulin-Potassium, Cardiac troponin.
https://arya.mui.ac.ir/article_10017.html
https://arya.mui.ac.ir/article_10017_fb3ba9407fb2d4990738a6cb5800996a.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
01
CAN TIMI RISK SCORE PREDICT ANGIOGRAPHIC INVOLVEMENT IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION?
EN
Allahyar
Golabchi
0000-0001-7179-5558
Cardiology Resident, Isfahan University of Medical Sciences, Isfahan
sadeghimasoumeh@gmail.com
Masoumeh
Sadeghi
0000-0001-7179-5558
Associate Professor of Cardiology, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan
Hamid
Sanei
Associate Professor of Cardiology, Isfahan University of Medical Sciences, Isfahan
Mohammad Reza
Akhbari
Cardiologist, Isfahan University of Medical Sciences, Isfahan,
Aliakbar
Tavassoli
Associate professor of Cardiology,
School of Medicine,
Isfahan University of Medical Sciences, Isfahan,
Seied Mostafa
Seiedhosseini
Cardiology Resident, Isfahan University of Medical Sciences, Isfahan
Pejman
Khosravi
Internal resident, Isfahan University of Medical Sciences, Isfahan
Ali Reza
Alisaeedi
Cardiology Resident, Isfahan University of Medical Sciences, Isfahan
BACKGROUND: In most studies, the agreeable risk scores for ST-elevation myocardial infarction (STEMI) consist of thrombolytic in myocardial infarction (TIMI) risk score and modified Gensini risk score. Researchers showed significant relations between TIMI with angiography scores in patients with UA/NSTEMI. We studied this relation in patients with STEMI. METHODS: We studied CCU patients with STEMI hospitalized in several hospitals of Isfahan, Iran from September 2007 to June 2008. Sampling method of 240 patients was random and simple. Exclusion criteria were incomplete history, nonspecific electrocardiogram changes, left bundle branch block and not accomplished angiography or accomplished angiography after 2 months of STEMI. Questionnaire indices collected on the basis of TIMI (0-14 points). Echocardiography and angiography were done and then, we used Gensini (0-400 points) to review films of angiography. Spearman`s rank test and Pearson correlation coefficient were used to study the relation between these scores. RESULTS: One hundred and sixty one patients were male and their average age was 60.02 years. Averages of TIMI and Gensini scores were 6.30 ± 2.5 and 120.77 ± 50.4, respectively. Study showed significant relation between TIMI, age and LVEF (P <0.001, r=-0.46). Also, between Gensini and age, gender and LVEF significant relation was found (P <0.001). But, a meaningful correlation didn’t exist between TIMI and the gender (P =0.08). Our study proved direct relation between TIMI risk scores and modified Gensini scores (P <0.001, r=0.55). CONCLUSION: We may decide quickly and correctly in emergency room to distinguish which patients with STEMI could derive a benefit from invasive strategies using TIMI score. Also, TIMI risk score can be a good predictor to determine the extension of coronary artery disease in patients with STEMI. As a result, we suggest determination of TIMI score for any patient entered emergency room. Also, this score should be recorded at the time patient’s discharge. Keywords: TIMI Risk Score, Modified Gensini Risk Score, LVEF, STEMI.
https://arya.mui.ac.ir/article_10018.html
https://arya.mui.ac.ir/article_10018_57a46b1e429d782fc489bfc119c6776c.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
13
RARE OCCURRENCE OF SIMULTANEOUS DISSECTION, PERFORATION AND THROMBOSIS OF EXTERNAL ILIAC ARTERY FOLLOWING DIAG-NOSTIC CORONARY ANGIOGRAPHY: A CASE REPORT
EN
Younes
Nozary
Interventionist, Tehran University of Medical Sciences, Tehran
Omid
Hashemi Fard
Interventionist, Isfahan Cardiovascular Research Center, Isfahan
omidhashemifard@yahoo.com
Lower extremity complications are the most common problems encountered during transfemoral diagnostic coronary artery angiography. Dissection, thrombosis and perforation of arteries of lower extremities although not uncommon, very rarely occur simultaneously. We did not find any report in the literature in this issue. In this report we describe a case of simultaneous occurrence of all three complications during coronary angiography in one patient. It also represents some of our uncertainties regarding the best management of the patient. In this patient, arterial perforation and dissection was managed conservatively, but we applied an invasive treatment (surgical thrombectomy) for arterial thrombosis with excellent short and long-term results. Keywords: Perforation, dissection, thrombosis, external iliac artery, acute arterial occlusion.
https://arya.mui.ac.ir/article_10012.html
https://arya.mui.ac.ir/article_10012_b27c4bfb7b2b73d388cbbbdcdbddb7d5.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
01
IATROGENIC FEMORAL ARTERY PSEUDOANEURYSM (REVIEW OF TREATMENT OPTIONS)
EN
Omid
Hashemi Fard
Interventional Cardiologist, Isfahan Cardiovascular Research Center, Isfahan
omidhashemifard@yahoo.com
BACKGROUND: Atherosclerosis, which is a result of gradual deposition of lipids in the lower part of blood vessel endothelium, is the leading cause of mortality and morbidity around the world. It has been proved that some inflammatory blood markers such as fibrinogen can predict the risk for cardiovascular disease conditions, not only in cardiovascular patients, but also in those who do not have any manifestations of the atherosclerotic development. In this study, the effect of cornus mas l. was evaluated on fibrinogen of hypercholesterolemic rabbits and it was also compared with lovastatin drug. METHODS: In this study, 25 New Zealand adult male rabbits were randomly divided into five groups of five. They were treated for 60 days by 5 different diets, namely basic, high cholesterol, regular plus 1 g/kgBW cornus mas L. powder, high cholesterol plus 1 g/kgBW cornus mas L. powder, and high cholesterol plus 10 mg/kgBW lovastatin. At the beginning and at the end of this period, blood samples were collected from the rabbits and their serum fibrinogen levels were measured. RESULTS: Cornus mas L. powder and lovastatin significantly decreased fibrinogen levels in comparison with high cholesterol group (P < 0.05). Furthermore cornus mas L. powder could reduce the fibrinogen level more than lovastatin (P < 0.05). CONCLUSION: The results indicated that consumption of cornus mas L. might be beneficial in atherosclerotic patients due to its reducing effects on fibrinogen. Keywords: Atherosclerosis, Fibrinogen, Lovastatin, Rabbits.
https://arya.mui.ac.ir/article_10011.html
https://arya.mui.ac.ir/article_10011_24e09bb5f6d07344b12ddaee3eb805c9.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
01
SOME NOTES ON STEM CELL THERAPY IN CARDIOVASCULAR DISEASES
EN
Mohammad Reza
Mohammadhasani
Islamic Azad University, Tehran Medical Branch, Tehran
reza1335@yahoo.com
Mandana
Hasanzad
Islamic Azad University, Tehran Medical Branch, Tehran
Amirreza
Mohammadhasani
Babol University of Medical Sciences, Babol
Mohammad
Samzadeh
Shahid Beheshti University of Medical Sciences, Tehran
Maryam
Eslami
Islamic Azad University, Tehran Medical Branch, Tehran
Cardiovascular diseases have become an increasing clinical issue worldwide. Acute ischaemic injury and chronic cardiomyopathies lead to permanent loss of cardiac tissue and ultimately heart failure. Current therapies widely aim to attenuate the pathological changes that occur after injury and to reduce risk factors of cardiovascular diseases. However, they do not improve the patient’s quality of life or the prognosis more than moderate. A new challenge in the treatment of the cardiovascular disease is cellular transplantation or cellular cardiomyoplasty. Different types of stem cells have been used for stem cell therapy. Clinical trials using primary bone-marrow-derived cells and skeletal myoblasts have also shown some encouraging results. An additional clinical and pre-clinical study to further enhance the beneficial effects of cell therapy is necessary. Recent studies have shown that there are various pools of putative resident stem cells in an adult heart, raising the hope that these cells can contribute to the treatment of cardiovascular diseases. Keywords: Stem Cell Therapy, Cardiovascular Disease, Iran.
https://arya.mui.ac.ir/article_10015.html
https://arya.mui.ac.ir/article_10015_553ad0a8f5057b7552a52b374089e525.pdf
Cardiovascular research institute, Isfahan University of Medical Sciences
ARYA Atherosclerosis Journal
1735-3955
2251-6638
6
2
2010
11
01
Journal Index
EN
Journal
Index
0000-0002-1825-0097
arya@crc.mui.ac.ir
Click to download the index of this issue.
https://arya.mui.ac.ir/article_10013.html
https://arya.mui.ac.ir/article_10013_5aa50601a48a6e59fb9285e4d053b8bb.pdf