ORIGINAL_ARTICLE
ASSESSMENT OF ANTIOXIDANT NUTRIENT INTAKE AND MALONDIADEHYDE PLASMA LEVEL IN RHEUMATOID ARTHRITIS
Abstract BACKGROUND: Elevated free radical generation in inflamed joints and impaired antioxidant systems have been implicated in rheumatoid arthritis (RA). The present study was performed to evaluate dietary nutrient intake and plasma oxidant status in RA patients. METHODS: This case-control study comprised 75 RA patients and equal number of age- and gender-matched controls. Nutrient intake was estimated by using a semi-quantitative food frequency questionnaire. Blood samples were obtained from each group, and as an indicator of oxidant status, plasma concentrations of malondiadehyde (MDA) were measured. RESULTS: The mean calorie intake of RA patients was lower than that of the healthy controls. Energy-adjusted intake of fat, vitamin A and ß-carotene were significantly lower in patients than in control .Plasma MDA concentration was significantly higher in RA patients than in controls (4.9±1.8 vs 2.1±0.6 nmoles/ml respectively, P < 0.01). CONCLUSION: These results suggest proper antioxidant nutrient intake management may reduce free radical generation and improve antioxidant status in RA patients. Keywords: rheumatoid arthritis, antioxidant, malondialdehyde.
https://arya.mui.ac.ir/article_10043_0143ddaf1901bc95d8e35d406285f58e.pdf
2009-12-01
Yousef
Shaabani
shabani@irimc.org
1
Msc, School of Nutrition and Food Sciences, Shaheed Beheshti University of Medical Sciences, Tehran.
LEAD_AUTHOR
Maryam
Foroughi
2
Msc, School of Health, Teharan University of Medical Science, Tehran.
AUTHOR
Reza
Rastmanesh
3
Assistant Professor, Department of Human Nutrition, School of Nutrition and Food Sciences, Tehran.
AUTHOR
Ahmadreza
Jamshidi
4
Associate Professor, Rheumatology Research Center, Teharan University of Medical Science, Tehran.
AUTHOR
Narges
Tajik
5
Msc, School of Health, Teharan University of Medical Science, Tehran.
AUTHOR
Omid
Assadi
6
Bsc, School of Nutrition and Food Sciences, Shaheed Beheshti University of Medical Sciences, Tehran.
AUTHOR
ORIGINAL_ARTICLE
COMPARISON OF ANTIOXIDANTS LEVEL IN TWO AREAS WITH HIGH AND LOW LEVELS OF ULTRAVIOLET B IN ISFAHAN PROVINCE
Abstract BACKGROUND: Ultraviolet radiation can contribute to various damages to body organs especially to skin. However, the effect of Ultraviolet B on the function of viruses, immunologic changes and antioxidants levels which protect human skin health are still unknown. We aimed to find the harmful level of UVB that can be helpful in taking preventive action against the increasing depletion of Ozone layer. METHODS: In this cross-sectional study conducted in Isfahan population, two areas with high and low levels of UVB radiation were investigated based on the information obtained from Meteorological Office. Samples in each area were selected by a cluster-sampling method. 250 persons were assigned to each group. The antioxidant capacity and glutathione peroxide level of samples were measured. Data were analyzed with Student t test by using SPSS software. RESULTS: The mean (± standard deviation) of Malondialdehide in high and low UVB radiation areas were 2.8 ± 0.32 and 1.65 ± 0.38 nmoles/ml, respectively (P < 0.001). Mean (± standard deviation) of antioxidants capacity levels were 81.6 ± 2.36 μmol/l in patients living in low UVB radiation area and 76.5 ± 2.6 μmol/l in patients living in high UVB radiation area (P < 0.0001). Glutathione Peroxide levels were 38.2 ± 1.7 and 35.3 ± 1.9 μmol/l in areas with low and high UVB radiation respectively (P < 0.0001). CONCLUSION: Findings of this study indicates that the amount of free radicals and antioxidant capacity in high UVB radiation areas are less than areas with low levels of UVB radiation. Therefore, it is suggested that necessary considerations should be taken into account for the residents of such areas in order to reduce its health damages. Keywords: Ultraviolet B, antioxidant, malondialdehyde, glutathione peroxide.
https://arya.mui.ac.ir/article_10044_c5974c607e056f451e603e8b022c61cb.pdf
2010-12-01
Mohammad-Bagher
Behyar
1
Assistant Professor, Meteorological Research Center, Meteorological Office, Tehran.
AUTHOR
Shahram
Moradi
shahram50047@yahoo.com
2
Specialist in Infectious Diseases, Skin Diseases and Leishmaniosis Research Center, Isfahan University of Medical Sciences, Isfahan.
LEAD_AUTHOR
Mohammad-Ali
Nilforoushzadeh
3
Assistant Professor of Dermatology, Tehran University of Medical Sciences, Tehran Skin and Leprosy Research Center, and Isfahan Skin Diseases and Leishmaniosis Research Center, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Leila
Shirani-Bidabadi
4
Medical Entomology, Skin Diseases and Leishmaniosis Research Center, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
ORIGINAL_ARTICLE
THE PREVALENCE OF CARDIOVASCULAR RISK FACTORS AND CORRELATION WITH NUTRITIONAL STATUS IN PATIENTS WITH TYPE 2 DIABETES
Abstract BACKGROUND: Type 2 diabetes is a major predictor of cardiovascular disease (CVD). There is a large body of evidence that nutrients have a important role in preventing and controlling of CVD risk factors. This study aimed to investigate the prevalence of CVD risk factors and their relations with nutrients and energy intake in patients with type 2 diabetes. METHODS: In this cross-sectional study, 107 patients with type 2 diabetes were recruited from individuals who underwent routine medical check-up in the out patient clinic of Shariati Hospital, Tehran, Iran. Patients were evaluated for age, anthropometric measures, blood pressure, fasting blood glucose, lipid profile and HbA1C. Nutrient intakes were obtained via 24- hour recall from each patient in three consecutive days. Nutrients and data analysis were done using FPII and SPSS version 13 soft wares. RESULTS: Overall, 10.9% and 87.9% of patients had respectively two and more than two CVD risk factors. The intakes of energy, protein, dietary fiber and vitamins including vitamin C, E, B12, B6, B3, B2, B1, B5 and mineral such as copper and zinc were less than the standard values (P < 0.001). The status of some nutrients intake was significantly correlated with some CVD risks factors. CONCLUSION: This study indicates a high prevalence of CVD risk factors among diabetic patients and emphasizes on the important role of nutrients intake in prevention and control of these risks. These findings suggest the necessity for improvement of nutrition status for reducing the prevalence of diabetes and CVD. Keywords: cardiovascular risk factors, nutrition, diabetes.
https://arya.mui.ac.ir/article_10045_bd624675eb5d7b67f2a050aa739f545b.pdf
2009-12-01
Sommaieh
Mohammadi
1
Emdadi hospital, Zanjan University of Medical Sciences, Zanjan.
AUTHOR
Mohammad javad
Hossein-zadeh Attar
hosseinzadeh.mdphd@yahoo.com
2
Department of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran.
LEAD_AUTHOR
Arash
Hossein-nejad
3
Endocrine and Metabolic Research Center, Tehran University of Medical Sciences, Tehran.
AUTHOR
Seyyed Hossein
Hosseini
4
School of Pharmacology, Islamic Azad University of Medical Sciences, Tehran.
AUTHOR
Mohammad Reza
Eshraghian
5
Department of Statistics, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences,
Tehran.
AUTHOR
Mehrdad
Karimi
6
Department of Traditional Medicine, Tehran University of Medical Sciences, Tehran.
AUTHOR
Nazila
Jafari
7
Internal Medicine, Social Security Organization, Tehran.
AUTHOR
Mazaher
Rahmani
8
Endocrine and Metabolic Research Center, Tehran University of Medical Sciences, Tehran.
AUTHOR
Farzaneh
Karimi
9
Endocrine and Metabolic Research Center, Tehran University of Medical Sciences, Tehran.
AUTHOR
ORIGINAL_ARTICLE
THE RELATION BETWEEN ANXIETY AND QUALITY OF LIFE IN HEART PATIENTS
Abstract BACKGROUND: The study aims to determine the relationship between anxiety and quality of life in patients with coronary artery disease (CAD). METHODS: Study participants included 56 CAD patients referred to Chamran Heart Center and Isfahan Cardiovascular Research Center both affiliated to Isfahan University of Medical Sciences. Sampling was random and Cattle anxiety scale and McNew quality of life questionnaire were used for data collection. A questionnaire was filled in for demographic characteristics. Data were analyzed using multiple regression analysis. RESULTS: The findings showed a strong significant inverse correlation between anxiety and quality of life in CAD patients. The strongest correlation among anxiety (manifest-hidden) and quality of life categories (physical -emotional – social category) was that between manifest anxiety and different categories of quality of life. CONCLUSION: Considering the significant relation between anxiety and quality of life in CAD patients, it is recommended to include methods of controlling anxiety in the treatment program of these patients. Keywords: anxiety, manifest anxiety, cardiovascular disease, quality of life.
https://arya.mui.ac.ir/article_10046_eb0b5e155743a5d30d5ba4b484e7756d.pdf
2010-12-01
Zohreh
Khayyam Nekouei
khayyamnekouei@gmail.com
1
MSc, Islamic Azad University of Khorasgan, Isfahan.
LEAD_AUTHOR
Alireza
Yousefy
aryousefy@edc.mui.ac.ir
2
Faculty Member of the Center for Development and Research in Medical Education, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Seyed Ahmad Reza
Khayyam Nekouei
3
Cardiologist, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Masoumeh
Sadeqhi
4
Associate Professor of Cardiology, Unit of Cardiovascular Disease in Women, Isfahan Cardiovascular Research Center, Isfahan Uni-versity of Medical Sciences, Isfahan.
AUTHOR
ORIGINAL_ARTICLE
NEW CORRELATION BETWEEN ANGLES OF WIDE QRS COMPLEX IN ELECTROCARDIOGRAM AND ECHOCARDIOGRAPHIC INDICES
Abstract BACKGROUND: Heart failure (HF) due to left ventricular (LV) systolic dysfunction has lesser survival than diastolic HF .We examined the correlation of two new angles(a and b) of QRS complex in the electrocardiogram (ECG) with indices including left ventricular ejection fraction (LVEF),left ventricular end systolic dimension (LVESD) and left ventricular end diastolic dimension (LVEDD) for predicting LVEF. METHODS: In this cross–sectional study,159 subjects with clinical signs of LV systolic dysfunction who presented to the Al-Zahra hospital in Isfahan, Iran , underwent echocardiography .First ,on the ECG ,two new angles defined and then these two angles compared manually and with computerized analysis by two different observers blinded to the another data. After confirmation of excellent correlation between these two forms, then two angles measured manually with protractor in 159 patients (wide QRS complex in 59 and normal in 100 patients). Then, correlation between these angles and echocardiographic indices were assessed. RESULTS: Statistical analysis revealed that in normal QRS complex, there was no correlation between any of two angles and echocardiographic indices. In contrast, in wide QRS complex,b angle and b/a ratio was correlated with any three echocardiographic indices (negative correlation with LVEF and positive correlation with LVESD and LVEDD) i.e. with decrease in LVEF and increase in LVESD and LVEDD, b angle is widened and b/a ratio increases. A LVEF of 30% corresponded to b/a ratio of 2 in wide QRS complex patients on the regression line. Linear regression analysis generated the regression line equation for predicting the LVEF. The equation is LVEF = 60.6 – (14.5 ´b/a ratio). CONCLUSION: b angle and b/a ratio can predict LVEF in patients with suspected HF and wide QRS complex. Keywords: Left ventricular systolic dysfunction, QRS angle, Electrocardiogram, ejection fraction.
https://arya.mui.ac.ir/article_10047_807e5e12f7490dc1b65f12e968747b87.pdf
2010-12-01
Morteza
Abdar Isfahani
abdar@mui.ac.ir
1
Associated Professor of Cardiology, Advanced Echocardiographist, Isfahan University of Medical Sciences, Isfahan.
LEAD_AUTHOR
Ali Akbar
Khorasani
2
MD, Cardiologist, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Mojtaba
Akbari
3
MSc, Biostatistics, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
ORIGINAL_ARTICLE
ASSESSMENT OF RELATION BETWEEN MICROALBUMINURIA AND ISCHEMIC ELECTROCARDIOGRAM IN IRANIAN GENERAL POPULATION
Abstract BACKGROUND: Enhancement of albumin exertion in urine increases the risk of renal and ischemic heart diseases (IHD). We assessed the association of urine albumin and sub-clinical IHD in a random sample of Iranian general population. METHODS: The random sample in general population in Isfahan County was recruited to the cross-sectional study. From the all sample blood pressure and lipid profile were assessed and morning urine spot was measured for albumin and Creatinine. Microalbuminuria was defined either Albumin-Creatinine Ratio (ACR) was 30-300mg. Also, the standard 12 lead electrocardiogram (ECG) was carried out for all participants. The ECG pattern was divided to two categories; normal or ECG with ischemia. The logistic regression model was determined the odds of albuminuria for ischemic changes in ECG. RESULTS: 999 subjects, age 35-70 years, participated to study. From all, 40.8% were male. Microalbuminuria was detected in 8% and sub-clinical ECG ischemic changes were found in 23.4%. The most frequent ischemic change was T wave inversion. The mean urine albumin levels in subjects with normal ECG was 9.6±14.6 mg/ml and in ischemic group was 8.5±12.2 mg/ml and they did not have statistically different. The odds ratios of neither Albumin-Creatinine ratio nor microalbuminuria were in significant range for risk to ischemic changes in ECG of apparently healthy participants. They was consecutively OR=0.9 (0.51-1.6), OR=0.99 (0.98-1.004). CONCLUSION: Our finding didn’t declare any association between ACR and IHD. Because of showing this association in the other study; it needs more exploration regarding to association between microalbuminuria and cardiovascular diseases incidence. Keywords: Ischemic heart diseases, electrocardiogram, Albumin-Creatinine Ratio, Urine Albumin
https://arya.mui.ac.ir/article_10048_2489b1460cd19217d2dc739a8b3071c7.pdf
2009-12-01
Alireza
Khosravi
alikh108@yahoo.com
1
Assistant professor of Cardiology. Isfahan Cardiovascular Research Center. Isfahan University of Medical Sciences, Isfahan.
LEAD_AUTHOR
Leili
Avesta
2
Resident of Cardiology. Department of Cardiology. Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Roya
Kelishadi
3
Associated professor of Pediatrics. Isfahan Cardiovascular Research Center. Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Mohammad Arash
Ramezani
4
Head of Surveillance Department. Isfahan Cardiovascular Research Center. Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Ahmad
Bahonar
5
Executive manager. Isfahan Cardiovascular Research Center. Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Hossein
Heydari
6
Isfahan Cardiovascular Research Center. Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Aliakbar
Tavassoli
7
Associated professor of Cardiology. Department of Cardiology. Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Nizal
Sarrafzadegan
8
Professor of Cardiology. Head of Isfahan Cardiovascular Research Center. Isfahan University of Medical Sciences, Isfahan.
AUTHOR
ORIGINAL_ARTICLE
ASSOCIATION OF ANTHROPOMETRIC INDEXES AND CARDIO-METABOLIC RISK FACTORS AMONG OBESE CHILDREN
Abstract BACKGROUND: Childhood obesity is associated with many cardio-metabolic risk factors, and different anthropometric measures have been considered to be associated with these risk factors. The aim of this study was to determine the best anthropometric index associated with cardio-metabolic risk factors among obese children and adolescents. METHODS: This study was conducted by using data of the records of 2064 obese children and adolescents aged 6-18 years. Body mass index (BMI), waist circumference (WC), waist- to- hip ratio (WHR) and waist- to-stature ratio (WSR) were considered as anthropometric indexes. The cardio-metabolic risk factors were total cholesterol (TC), LDL-cholesterol (LDL-C),HDL-cholesterol (HDL-C), triglycerides (TG), fasting blood sugar (FBS), diastolic and systolic blood pressure (SBP and DBP).Data were analyzed with SPSS16 using Receiver Operator Curve (ROC) and Pearson correlation analyses. RESULTS: The prevalence of high LDL -C, TC, TG, FBS, SBP / DBP and low HDL - C was higher in boys than in girls. No single anthropometric index was found to be associated with risk factors in different sex and age groups. BMI, WC and WSR but not WHR had significant correlation with TC, LDL - C, TG, and FBS, whereas HDL - C had no significant correlation with anthropometric indexes. CONCLUSION: Our results showed that in spite of all its limitations in differentiating fat mass and obesity pattern, BMI can be considered as a useful anthropometric index for predicting cardio-metabolic risk factors in obese children and adolescents. It may be clinically useful in pediatric population to routinely use WC and WSR -but not WHR- as a screening tool to identify at-risk children. Keywords: Anthropometric measures, fat distribution, cardiovascular risk factors, children.
https://arya.mui.ac.ir/article_10049_d5d429d76a3aa0a3a7041581374d1047.pdf
2010-12-01
Mahin
Hashemipour
1
Professor of Pediatric Endocrinology, Endocrine&Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Mehrnaz
Soghrati
2
Physician, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Mohammad
Malekahmadi
3
Physician, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Mojgan
Soghrati
4
Physician, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Parisa
Mirmoghtadaei
5
Specialist in Community Medicine, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Parinaz
Poursafa
6
Research Assistant, Pediatric Preventive Cardiology Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan.
AUTHOR
Roya
Kelishadi
kelishadi@med.mui.ac.ir
7
Associate Professor of Pediatrics, Pediatric Preventive Cardiology Department, Isfahan Cardiovascular Research Center, Isfahan Uni-versity of Medical Sciences, Isfahan.
LEAD_AUTHOR
ORIGINAL_ARTICLE
TRANSIENT CORTICAL BLINDNESS: A MUST KNOW COMPLICATION OF CORONARY ANGIOGRAPHY
Abstract INTRODUCTION: This is a case of transient visual loss following trans-femoral coronary angiography in a 44 year- old man, which lasted for 2 days. CASE REPORT: Ophthalmologic, neurological and radiological studies using physical exam and brain MRI showed no pathological finding. CONCLUSION: Visual loss resolved completely without any sequel in 2 days. The leakage of contrast agent into occipital area of the brain could possibly be the cause. Keywords: Complication of coronary angiography, Transient Cortical Blindness
https://arya.mui.ac.ir/article_10050_57f6f5ad0b44b0fc65c3b4d070bdd001.pdf
2010-12-02
Farhad
Fazel
fazel43@yahoo.com
1
Department of Ophthalmology, Feiz Hospital, Isfahan University Of Medical Sciences, Isfahan.
LEAD_AUTHOR
Ali
Abdalvand
2
Emergency Medicine Resident, Shahid Beheshti University Of Medical Sciences, Tehran.
AUTHOR