@article { author = {Shemirani, Hasan and Tajmirriahi, Marzieh and Nikneshan, Ali and Kleidari, Behrooz}, title = {The relation between obesity and left ventricular diastolic function in young people: A cross-sectional study}, journal = {ARYA Atherosclerosis Journal}, volume = {17}, number = {1}, pages = {1-6}, year = {2022}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {10.22122/arya.v17i0.2251}, abstract = {BACKGROUND: It has been proposed that left ventricular diastolic dysfunction (LVDD) is a possible physiological link between high body mass index (BMI) and future occurrence of heart failure (HF). The present cross-sectional study was aimed to analyze the association between BMI and LVDD by transthoracic echocardiography (TTE).METHODS: This study was conducted from May 2017 to September 2019 in Khorshid Hospital of Isfahan University of Medical Sciences, Isfahan, Iran. Based on the calculated BMI (kg/m²), patients were divided into three groups: group 1: subjects with BMI < 25, as a normal group (n = 75), group 2: volunteer cases with 40 > BMI ≥ 30, as an obese group (n = 98), and group 3: patients with BMI ≥ 40, as a morbidly obese group (n = 100). TTE was performed by a trained cardiologist and associated variables including left atrium (LA) volume, E, septal e’, lateral e’,andE/e’ were assessed and also subjects were characterized as normal diastolic function, abnormal diastolic function, and inconclusive diagnosis of diastolic dysfunction (DD).RESULTS: Apart from the ejection fraction (EF) and the tricuspid regurgitation velocity (TRV), there was a significant difference between the other echocardiographic variables including LA volume, E, septal e’, lateral e’, and E/e’ (P < 0.05). One patient with morbid obesity in our study revealed LVDD. There was no significant difference between three groups (P = 0.42).CONCLUSION: There is no considerable relationship between obesity and LVDD. It seems that the absence of associated comorbidities such as diabetes, coronary disorders, etc. plays a crucial role in preventing LVDD, but for realistic and definitive decision, more cellular and molecular investigations and studies with larger sample size are necessary.}, keywords = {Obesity,Body Mass Index,Left Ventricular,Diastolic Heart Failure}, url = {https://arya.mui.ac.ir/article_10795.html}, eprint = {https://arya.mui.ac.ir/article_10795_f921afb165a12d084ff44830ce081105.pdf} }