@article { author = {Mirhashemi, Seyyed Mehdi and Najafi, Vajiheh and Raygan, Fariba and Asemi, Zatollah}, title = {The effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: A randomized, double-blind, placebo-controlled trial}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {158-165}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Limited data are present that have assessed the effects of coenzyme Q10 (CoQ10) intake on cardiometabolic markers in type 2 diabetic patients with coronary heart disease (CHD). This study was done to determine the effects of CoQ10 administration on cardiometabolic markers in overweight diabetic patients with stable myocardial infarction. METHODS: This randomized double-blind placebo-controlled clinical trial was done among 60 diabetic patients with CHD aged 45-75 years old. Subjects were randomly allocated into two groups to receive either 100 mg/day CoQ10 supplements (n = 30) or placebo (n = 30) for 8 weeks. RESULTS: Compared with the placebo, CoQ10 intake led to a significant reduction in serum interleukin 6 (IL-6) (-1.7 ± 1.6 vs. 0.8 ± 1.7 ng/l, P < 0.001) and protein carbonyl (PCO) levels (-0.2 ± 0.3 vs. 0.1 ± 0.2 nmol/mg protein, P < 0.001). Supplementation with CoQ10 did not affect serum lipoprotein(a), advanced glycation end-products and thiol concentrations compared with the placebo. CONCLUSION: Overall, this study indicated that CoQ10 intake after 8 weeks among diabetic patients with the stable CHD had beneficial effects on serum IL-6 and PCO levels, but did not alter other cardiometabolic markers.  }, keywords = {Coenzyme Q10,Supplementation,Cardiometabolic Markers,Type 2 Diabetes Mellitus,Coronary Heart Disease}, url = {https://arya.mui.ac.ir/article_10533.html}, eprint = {https://arya.mui.ac.ir/article_10533_b328a387cdec426b7401fa63c082e4d1.pdf} } @article { author = {Roohafza, Hamidreza and Kabir, Ali and Sadeghi, Masoumeh and Shokouh, Pedram and Ahmadzad-Asl, Masoud and Khadem-Maboudi, Ali Akbar and Sarrafzadegan, Nizal}, title = {Stress as a risk factor for noncompliance with treatment regimens in patients with diabetes and hypertension}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {166-171}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: We have assessed the role of stress on compliance of patients with diabetes mellitus (DM) and hypertension (HTN) with taking prescribed medications and following dietary and exercise regimens. METHODS: A total of 9544 individuals more than 19 years of age were selected from three counties in central Iran. The presence of DM and HTN were asked from participants. We defined treatment adherence (compliance) based on agreement of individual’s self-report behavior with recommendations from a physician. RESULTS: Awareness about DM and HTN was 82.6% and 49.9%, respectively. Multivariate analysis showed that odds ratio (OR) of high to low stress level was lower than one for both “usage of medication” and “following exercise regimen” in diabetics even after adjustment for either “age and sex” or “age, sex and education”. In hypertensive patients, OR of high to low stress level was lower than one for “usage of medication” even after adjustment for either “age and sex” or “age, sex and education” and also lower than one for “following exercise regimen” only as crude index. CONCLUSION: Cases with higher stress level had lower compliance for accepting either medication or exercise as a treatment option for their DM or HTN. }, keywords = {Stress,Patient Compliance,Risk Factors,Exercise,Diabetes Mellitus,Hypertension}, url = {https://arya.mui.ac.ir/article_10534.html}, eprint = {https://arya.mui.ac.ir/article_10534_a7e2525f06079301840df943d519b3cb.pdf} } @article { author = {Rouhani, Mohammad Hossein and Larijani, Bagher and Azadbakht, Leila}, title = {Are the price patterns of cardioprotective vs. unhealthy foods the same? A report from Iran}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {172-179}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Although several studies have assessed the price of different food groups in developed countries, there is scarce evidence regarding developing countries. Also, there is no report regarding the price of cardioprotective compared with unhealthy foods. The aim of this study was to determine the trend of food cost across different food groups (cardioprotective vs. unhealthy) and to assess the association between food cost and nutritional quality of foods in Iran. METHODS: A list of foods consumed frequently by Iranian population was provided. Nutritional quality of foods was assessed by energy density and nutrient rich foods (NRF) index. Food groups were defined according to the US Department of Agriculture (USDA) MyPlate food groups. The price of food groups was reported as kcal/price and price/serving. RESULTS: Although a positive association between different types of NRF, nutrient content of foods and food price was observed, there was an inverse relationship between food price and energy density. The kcal/price of "oils" was less than "whole grains" and "refined grains". "Sugar, sweets and beverages" and "beans and legumes" food groups had equal kcal/price media. Among healthy foods for cardiovascular system, nuts had the highest price/serving. On the other hand, among unhealthy foods for cardiovascular system, processed meat had the highest price/serving. The price/serving of healthy oils was similar to saturated and trans fatty acids rich oils. Also, the price/serving of low-fat (healthy) vs. high fat (unhealthy) dairy was not different. Similar finding was observed for white meat vs. red meat. CONCLUSIONS: Our findings revealed that the pattern of food price in Iran is different from developed countries. Also, we found that Iranians can consume a cardioprotective diet without any economic pressure. }, keywords = {Food Price,Nutritional Quality,Cardioprotective Agents,Unhealthy Foods,Developing Country}, url = {https://arya.mui.ac.ir/article_10535.html}, eprint = {https://arya.mui.ac.ir/article_10535_e5936e2db2cff31fab675dc8ca0d6ba9.pdf} } @article { author = {Nasri, Hamid Reza and Shahouzehi, Beydolah and Masoumi-Ardakani, Yaser and Iranpour, Maryam}, title = {Effects of digoxin on cardiac iron content in rat model of iron overload}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {180-184}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Plasma iron excess can lead to iron accumulation in heart, kidney and liver. Heart failure is a clinical widespread syndrome. In thalassemia, iron overload cardiomyopathy is caused by iron accumulation in the heart that leads to cardiac damage and heart failure. Digoxin increases the intracellular sodium concentration by inhibition of Na+/K+-ATPase that affects Na+/Ca2+ exchanger (NCX), which raises intracellular calcium and thus attenuates heart failure. The mechanism of iron uptake into cardiomyocytes is not exactly understood. METHODS: We assessed the effect of different concentrations of digoxin on cardiac iron content in rat model of iron overload. Digoxin had been administrated intraperitoneally (IP) for one week before main study began to assure increased digoxin levels. Group 1 received four IP injections of iron-dextran (12.5mg/100g body weight) every 5 days evenly distributed over 20 days. Groups 2-4 received 0.5, 1 and 5 mg/kg/day IP digoxin, respectively. Last three groups 5-7 received iron-dextran as group 1 and digoxin concentrations 0.5, 1 and 5 mg/kg/day respectively. RESULTS: Cardiac iron contents were significantly higher in iron overload groups that received different concentrations (0.5, 1 and 5 mg/kg/day) of digoxin than their counterparts in control groups and this pattern was also observed in pathology assessment. CONCLUSION: It seems that digoxin plays an important role in iron transport into heart in iron overload state but exact mechanism of this phenomenon is not clear. L-type Ca2+ channels are good candidates that probably could be involved in iron accumulation in cardiomyocytes. Thus it would be better to reconsider digoxin administration in thalassemia and iron overload conditions }, keywords = {Iron Overload, Digoxin,Iron Dextran Complex,Cardiac Iron Content}, url = {https://arya.mui.ac.ir/article_10536.html}, eprint = {https://arya.mui.ac.ir/article_10536_7bd64d18ef8d9c74e151c4cf8d44575a.pdf} } @article { author = {Rafiee Alhossaini, Mahsa and Hassanzadeh, Akbar and Feizi, Awat and Sarrafzadegan, Nizal}, title = {Transition in public knowledge of risk factors of cardiovascular disease in an Iranian general population: A latent transition analysis (LTA) on a longitudinal large community-based educational prevention program}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {185-191}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Cardiovascular diseases (CVD) are the second leading cause of death, after accidents, in Iran. This study was performed to assess the change in levels of knowledge about 8 risk factors of CVD and its associated determinants the Iranian general population.METHODS: The current repeated cross-sectional study included 3014 people in 2004, 3012 in 2005, and 4719 in 2007, aged older than 19 years. Knowledge about 8 risk factors (high blood pressure, nutrition, physical inactivity, smoking, diabetes, heredity, stress, and obesity) as the major causes of CVD was evaluated using latent transition analysis (LTA).RESULTS: The most widely known CVD risk factors were nutrition and physical inactivity followed by stress. In addition, old age, low level of education, male gender and low socioeconomic status (SES) level were the significant determinants of low knowledge levels of CVD risk factors. Besides, individuals’ knowledge of CVD risk factors increased across the time.CONCLUSION: Public knowledge of CVD risk factors has increased; however significant gaps continue to exist, particularly among the elderly, less-educated people, people in low socioeconomic status level and men. Future intensified educational efforts by policymakers are necessary for improving knowledge of CVD, particularly among high-risk groups.}, keywords = {Cardiovascular Disease,Risk Factors,Prevention,Awareness,Latent Transition Analysis}, url = {https://arya.mui.ac.ir/article_10537.html}, eprint = {https://arya.mui.ac.ir/article_10537_29bacbb8a8f60a05a1877604fdf8a1a0.pdf} } @article { author = {Mirmohammadsadeghi, Mohsen and Salimi-Jazi, Fereshteh and Rabbani, Majid}, title = {Multiple right coronary artery fistulas to coronary sinus: A case report and literature review}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {192-194}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Coronary arteriovenous fistula is a rare congenital or acquired abnormal connection between a coronary artery and any of the great vessels or any of the heart chambers. Most of them are diagnosed during routine coronary angiography. CASE REPORT: This case report illustrates a successful surgical ligating of multiple right coronary artery and circumflex artery fistulas to coronary sinus. CONCLUSION: According to our experience and literature review, it can be concluded that to prevent potential complications in various cases of coronary arteriovenous fistula, early surgical management, just after their condition has been diagnosed, is the best choice }, keywords = {Coronary Arteriovenous Fistula,Right Coronary Artery,Dilated Coronary Sinus}, url = {https://arya.mui.ac.ir/article_10538.html}, eprint = {https://arya.mui.ac.ir/article_10538_b4be515101bf423382ee8d50af6c6e9e.pdf} } @article { author = {Eizadi-Mood, Nastaran and Aboufazeli, Elham and Hajhashemi, Valiollah and Gheshlaghi, Farzad and Badri, Shirinsadat and Sabzghabaee, Ali Mohammad}, title = {Effect of intravenous midazolam on cardiac parameters in acute tricyclic antidepressants poisoning}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {195-200}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Midazolam is commonly and safely used in poisoning management and intensive care for the control of the agitated poisoned patients. Despite the introduction of newer and safer antidepressants, tricyclic antidepressants (TCA) are still prescribed and used in many countries due to their cost-effectiveness. Severe morbidity and mortality associated with these drugs arises largely from their well-documented cardiovascular toxicity. In this study we aimed to investigate the probable effect of midazolam on some hemodynamic indices in TCA poisoned patients. METHODS: In this clinical study we have evaluated some cardiovascular and hemodynamic indices of 100 TCA poisoned patients whom were randomly allocated for receiving midazolam with a first loading dose of 0.1 mg / kg (2 mg /min.) followed by a 6-hours maintenance infusion of 0.1 mg /kg /h of the drug in dextrose-saline (3.33% of dextrose and 0.33% of NaCl) or placebo (dextrose-saline infusion without midazolam). Pulse rate, systolic/diastolic blood pressure, respiratory rate, neurologic status and the outcome of therapy were recorded at the time of admission and hourly for the next 6 hours. RESULTS: There was a statistically significant reduction in the heart rate of the midazolam treated group after the first hour of hospital admission. There were no significant differences in the respiratory rate, central nervous system manifestations and other indices between the two groups.  CONCLUSION: Midazolam may reduce tachycardia (and its fatal consequences) in the first hour of admission in TCA poisoned patients.   }, keywords = {Midazolam,Tricyclic antidepressants (TCAs) Poisoning,Tachycardia}, url = {https://arya.mui.ac.ir/article_10539.html}, eprint = {https://arya.mui.ac.ir/article_10539_eb83bd6ee411e629b08ec9ba2766b488.pdf} } @article { author = {Baharvand-Ahmadi, Babak and Sharifi, Khalil and Namdari, Mehrdad}, title = {Prevalence of non-alcoholic fatty liver disease in patients with coronary artery disease}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {201-205}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {Background: Several common metabolic risk factors contribute to development of both non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD). The  aim was to determine prevalence of NAFLD in patients with CAD. Methods: This prospective study was carried out from December2011 to June2012. All patients with documented diagnosis of CAD with stenosis of one of the main coronary arteries or their branches were included in the study. Ultrasound examination of liver was performed in all patients to diagnose hepatic steatosis. Accordingly the severity of steatosis was graded from 0 (absence of steatosis) to 3 (severe steatosis). Finally, prevalence of NAFLD was determined in the studied patients. Results: Among 170 patients with CAD included in the study, 63 and 17 cases respectively, had grade 1 and grade 2 hepatic steaotosis in ultrasound examination providing prevalence of 47% in studied population.  There was no significant differences between patients with NAFLD and those without NAFLD regarding gender (p= 0.12), presence of diabetes mellitus (p=0.27), hyperlipidemia (p=0.21) and hypertension (p=0.87).  There was no association between involvement of left anterior descending artery and hepatic steatosis (p=0.87). Conclusions: The present study indicated a high prevalence of NAFLD in patients with documented CAD.}, keywords = {Non-Alcoholic Fatty Liver Disease,Coronary Artery Disease,Ultrasound}, url = {https://arya.mui.ac.ir/article_10540.html}, eprint = {https://arya.mui.ac.ir/article_10540_4ffaa7833dfe0eae6d22c8f4ec5b765f.pdf} } @article { author = {Mohandes, Mohsen and Rojas, Sergio and Guarinos, Jordi and Fernández, Francisco and Oliva, Xavier and Noueched, Marianela and Bardaji, Alfredo}, title = {Efficacy and safety of Tornus catheter in percutaneous coronary intervention of hard or balloon-uncrossable chronic total occlusion}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {206-211}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Balloon advancement and dilation through chronic total occlusion segment could be challenging in some cases after successful wire crossing. The purpose of this study was to evaluate efficacy and safety of Tornus catheter in percutaneous coronary intervention of chronic total occlusion in hard or balloon-uncrossable chronic total occlusion. METHODS: The present study is a retrospective and descriptive analysis of 14 hard or balloon-uncrossable chronic total occlusions treated percutaneously in our cath. Tornus catheter was used to penetrate and eventually cross the chronic total occlusion segment. Procedure success was defined when Tornus penetrated at least partly into chronic total occlusion segment making possible the subsequent balloon dilatation and stent implantation achieving a final TIMI III angiographic result with residual stenosis less than 30%. Switch to other microcatheter was considered as an unsuccessful procedure. Complications associated with the Tornus use were analyzed in order to evaluate device safety. RESULTS: The average age of patients was 65.2 ± 9.6 and 11 out of 14 (78.6%) were male. In 7 (50%) cases, Tornus was used after an unsuccessful balloon passage through occluded segment. In 11 (78.6%) out of 14 cases the procedure was successful and in 3 (21.4%) cases, the operator switched to another microcatheter to continue with the procedure. No complication occurred during all procedures. CONCLUSION: Tornus catheter can be effectively and safely used in a subgroup of patients undergoing percutaneous coronary intervention of chronic total occlusion with hard or balloon-uncrossable lesions and could facilitate the treatment of this type of lesions. }, keywords = {Percutaneous Coronary Intervention,Coronary Occlusion,Catheter}, url = {https://arya.mui.ac.ir/article_10541.html}, eprint = {https://arya.mui.ac.ir/article_10541_656b7f07894d5a2cb1f5caf45d1bf9e1.pdf} } @article { author = {Journal, Index}, title = {Journal Index}, journal = {ARYA Atherosclerosis Journal}, volume = {12}, number = {4}, pages = {-}, year = {2016}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {Click to download the index of this issue.}, keywords = {}, url = {https://arya.mui.ac.ir/article_10532.html}, eprint = {https://arya.mui.ac.ir/article_10532_832158c7a81718eb9622cfa62006770f.pdf} }