@article { author = {Nakhaee, Alireza and Hashemi, Mohammad and Rezaeifar, Alireza and Kaykhaei, Mahmoud Ali}, title = {Evaluation of haptoglobin genotypes in patients with metabolic syndrome: A preliminary report}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {167-172}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Haptoglobin (Hp) polymorphisms have been suggested to be associated with many pathological conditions, including cardiovascular diseases, infectious diseases, and type 2 diabetes. For the first time, we aimed to investigate the possible association between Hp genotypes and metabolic syndrome (MES) in a sample of Iranian subjects. METHODS: In this study, 291 patients with MES according to National Cholesterol Education Program-Adult Treatment Panel III criteria, and 284 healthy individuals have been studied. We determined Hp genotype by polymerase chain reaction. RESULTS: The frequency of three genotype (Hp1-1, Hp2-1, and Hp2-2) in healthy individuals and patients were 7.74, 39.7, 52.46, and 7.9, 31.61, 60.48 percent, respectively. There was no significant difference between the groups regarding Hp genotypes. The Hp2 allele was the predominant allele in MES (76.29%) and normal subjects (72.54%). CONCLUSION: Hp polymorphisms are not risk factor for predisposition to MES in a sample of the Iranian population. Further studies with different ethnicities are required to validate our findings.   }, keywords = {Haptoglobin,Phenotype,Metabolic Syndrome}, url = {https://arya.mui.ac.ir/article_10468.html}, eprint = {https://arya.mui.ac.ir/article_10468_5c83c5cffc575434728e542d11ee5244.pdf} } @article { author = {Bayat, Fatemeh and Faritous, Zahra and Aghdaei, Nahid and Dabbagh, Ali}, title = {A study of the efficacy of furosemide as a prophylaxis of acute renal failure in coronary artery bypass grafting patients: A clinical trial}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {173-178}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Renal failure is a frequent event after coronary artery bypass grafting (CABG). Hemodynamic alterations during surgery as well as the underlying disease are the predisposing factors. We aimed to study intermittent furosemide therapy in the prevention of renal failure in patients undergoing CABG. METHODS: In a single-blind randomized controlled trial, 123 elective CABG patients, 18-75 years, entered the study. Clearance of creatinine, urea and water were measured. Patients were randomly assigned into three groups: furosemide in prime (0.3-0.4 mg/kg); intermittent furosemide during CABG (0.2 mg/kg, if there was a decrease in urinary excretion) and control (no furosemide). RESULTS: There was a significant change in serum urea, sodium and fluid balance in “intermittent furosemide” group; other variables did not change significantly before or after the operation. Post-operative fluid balance was significantly higher in “intermittent furosemide” group (2573 ± 205 ml) compared to control (1574 ± 155 ml) (P < 0.010); also, fluid balance was higher in “intermittent furosemide” group (2573 ± 205 ml) compared to “furosemide in prime” group (1935 ± 169 ml) (P < 0.010). CONCLUSION: The study demonstrated no benefit from intermittent furosemide in elective CABG compared to furosemide in prime volume or even placebo.   }, keywords = {Renal Failure,Coronary Artery Bypass Grafting,Furosemide}, url = {https://arya.mui.ac.ir/article_10469.html}, eprint = {https://arya.mui.ac.ir/article_10469_cba7e6046e2b7f80607606c914529b90.pdf} } @article { author = {Yousefzadeh, Gholamreza and Shokoohi, Mostafa and Najafipour, Hamid and Shadkamfarokhi, Mitra}, title = {Applying the Framingham risk score for prediction of metabolic syndrome: The Kerman Coronary Artery Disease Risk Study, Iran}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {179-185}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: There has been a few studies about the predictability of metabolic syndrome (MetS) based on the Framingham risk score (FRS) as a tool for predicting the risk of 10-years cardiovascular diseases (CVD) in Iranian population. The aim of this study was to compare the risk stratification obtained with the FRS and MetS in a cohort of the Iranian population. METHODS: In this population-based study Kerman Coronary Artery Disease Risk study, Iran, MetS was diagnosed as defined by the revised National Cholesterol Education Program definition criteria (ATPIII) and the FRS was calculated using a computer program, previously reported algorithm. RESULTS: Overall, the prevalence 10-years risk of CVD for patients with MetS was significantly different with those without MetS (74.3 vs. 86.4% for low-risk patients, 18.1 vs. 12.3% for intermediate-risk people, and 7.6 vs. 1.3% for high-risk individuals) (P < 0.001). The frequency of intermediate-risk and high-risk for 10-year CVD in men with MetS (39.5 and 18.3%, respectively) was considerably higher than women with MetS (3.2 and 0.1%, respectively). Using multiple logistic regression, the odds ratio of MetS in intermediate-risk and high-risk FRS group was 1.7 and 6.7, respectively (P < 0.001). CONCLUSION: Significant association between the presence of MetS and high risk for CVD based on FRS was revealed in both men and women indicating a good concordance between MetS and FRS in predicting the risk of CVDs. However, the odds ratio of the development of risk of cardiovascular events among women was higher than men with MetS. }, keywords = {Metabolic Syndrome,Framingham Risk Score,Cardiovascular Disease,Ischemic Heart Disease}, url = {https://arya.mui.ac.ir/article_10470.html}, eprint = {https://arya.mui.ac.ir/article_10470_5a7914a85772a85983db38290fe92495.pdf} } @article { author = {Mirmohammadsadeghi, Pouya and Mirmohammadsadeghi, Mohsen}, title = {Effects of single antegrade hot shot in comparison with no hot shot administration during coronary artery bypass grafting}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {186-190}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Superior results will be achieved from cardiac surgery by minimizing the effect of ischemia/reperfusion injury during cross-clamping of the aorta. Different cardioplegia solutions have been introduced, but the optimum one is still ambiguous. The aim of this study is to determine the effect of single antegrade hot shot terminal warm blood cardioplegia (TWBC) on patients who had undergone coronary artery bypass grafting (CABG). METHODS: In total, 2488 patients who had CABG surgery in Sina Hospital, Isfahan, Iran, from 2003 to 2011 were enrolled in this case-control study. They were divided into two groups, those who received cold cardioplegia only and those who received a hot shot following cold cardioplegia. Demographics, and clinical data, such as; premature atrial contraction (PAC) arrhythmia, diabetes treatment, and left ventricular ejection fraction (EF), were collected and logistic regression analysis was used to analyze the data. RESULTS: There were significant differences found between subjects receiving antegrade hot shot based on direct current (DC) shocks, with regard to; female, EF levels, diabetes treatment (P < 0.050). Those who did not receive the hot shot and were not diabetic received more DC shock (P = 0.019). The prevalence of subjects who did no need DC shock was significantly higher among male subjects who had good EF and acceptable diabetic treatment. Multiple logistic regression showed that PAC arrhythmia did not have a significant effect on receiving DC shock during CAGB [0.84 (0.25, 2.85), (P = 0.780)]. Having poor EF increased the risk of receiving DC shock among subjects by 2.81 [(1.69, 4.69), (P ≤ 0.001)] (P < 0.001). Among the diabetic subjects, receiving insulin decreased the risk of receiving DC shock by 0.54 (0.29, 0.98) (P = 0.042). CONCLUSION: It was concluded that single antegrade hot shot following cold cardioplegia was not particularly effective in the CABG group. TWBC will decrease the need for DC shock.   }, keywords = {Coronary Artery Bypass,Heart Arrest,Induced,Stroke,Mortality,Oxidative Stress,Reperfusion Injury}, url = {https://arya.mui.ac.ir/article_10471.html}, eprint = {https://arya.mui.ac.ir/article_10471_fcfab54d12802fe6277596b2893fbf61.pdf} } @article { author = {Saneipour, Maryam and Ghatreh-Samani, Keihan and Heydarian, Esfandiar and Farrokhi, Effat and Abdian, Narges}, title = {Adiponectin inhibits oxidized low density lipoprotein-induced increase in matrix metalloproteinase 9 expression in vascular smooth muscle cells}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {191-195}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: High expression of matrix metalloproteinase 9 (MMP9) during vascular injury and inflammation plays an important role in atherosclerotic plaque formation and rupture. In the process of atherosclerosis, oxidized low-density lipoprotein (oxLDL) upregulates MMP9 in human aortic vascular smooth muscle cells (HA/VSMCs). Adiponectin is an adipose tissue-derived hormone that has been shown to exert anti-atherogenic and anti-inflammatory effects. The aim of this study was to investigate the effect of adiponectin on MMP9 expression under pathogenic condition created by oxLDL in HA/VSMCs. METHODS: In this experimental study, HA/VSMC were stimulated with oxLDL alone and in the presence of adiponectin for 24 and 48 h. The expression of MMP9 gene was determined by real-time polymerase chain reaction method. The protein level of this gene was investigated by western blotting technique. RESULTS: An oxLDL increased MMP9 expression 2.16 ± 0.24- and 3.32 ± 0.25-fold after 24 and 48 h, respectively and adiponectin decreased oxLDL-induced MMP9 expression in a time-dependent manner. CONCLUSION: These results show that adiponectin changes extracellular matrix by reducing MMP9 mRNA and protein, therefore, may stabilize lesions and reduce atheroma rupture. }, keywords = {Matrix Metalloproteinase 9,Adiponectin,Oxidized Low Density Lipoprotein}, url = {https://arya.mui.ac.ir/article_10472.html}, eprint = {https://arya.mui.ac.ir/article_10472_dad76b5cacaaca31ae06c492e28fddd8.pdf} } @article { author = {Ranjbar, Fatemeh and Akbarzadeh, Fariborz and Zakeri, Faramarz and Farahbakhsh, Mostafa and Nazari, Mohammad Ali}, title = {Effects of citalopram on heart rate variability in women with generalized anxiety disorder}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {196-203}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Heart rate variability (HRV) is defined as variations in R-R interval with time. Dysautonomia is common in patients with psychiatric disorders such as depression and anxiety. Using HRV analysis, recent studies showed that in anxiety disorders, the vagal cardiac function decreases, and sympathetic function increases. This study aimed at investigating citalopram effects on HRV. METHODS: This before and after study was conducted in 25 generalized anxiety disorder (GAD) patients. GAD was diagnosed based on clinical interview according to diagnostic and statistical manual of mental disorders IV-Text revised (DSM-IV-TR) criteria using Structured Clinical Interview for DSM Disorders-I questionnaire. A cardiologist studied 24 h ambulatory monitoring of the electrocardiogram (Holter) on all patients before the treatment. A volume of 20 mg of citalopram was administered to the subjects on a daily basis. Then, they were studied by Holter monitoring again after 1-month of administration of citalopram. RESULTS: The average age of participants was 35.32 ± 8.7. The average Holter monitoring time was 23.29 ± 1.14 h before treatment and 23.81 ± 0.68 after it. The 3 h low frequency/high frequency ratio was significantly different between 3 h segments of time before treatment (P < 0.001). This difference was even higher after treatment (P = 0.001). Data showed an increase in parasympathetic tone during sleep both before and after treatment. CONCLUSION: These patients showed some impairments of HRV indices that did not improve by citalopram in future, the clinical importance of such disturbances should be evaluated in details with prolonged follow-up and greater sample size.   }, keywords = {Anxiety disorders,Heart Rate,Ambulatory electrocardiography}, url = {https://arya.mui.ac.ir/article_10473.html}, eprint = {https://arya.mui.ac.ir/article_10473_686f0517d0ad857d5a15722dbb05f144.pdf} } @article { author = {Kassaian, Seyed Ebrahim and Fallahi, Faramarz and Shirzad, Mahmood and Sahebjam, Mohammad and Salarifar, Mojtaba}, title = {Percutaneous aortic valve implantation in bicuspid aortic valve: A case report}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {204-207}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Transcatheter aortic valve implantation (TAVI) was known as an alternative technique for treatment of severe aortic stenosis (AS). This technique is controversial in bicuspid aortic valve (BAV). Here, we report TAVI for severe AS in a BAV setting in a patient with serious lung disease. CASE REPORT: A 68-year-old woman with a history of coronary artery bypass graft, BAV and severe AS, asthma, who had repeatedly denied any suggestion for open heart surgery, was our volunteer candidate for TAVI. The peak and mean pressure gradient decreased from 53 and 43 mm Hg to 13and 6 mm Hg respectively. CONCLUSION: TAVI could be a viable option for highly selected patients with AS and BAV who have a prohibitive risk for open heart surgery. }, keywords = {Transcatheter Aortic Valve Implantation,Aortic Stenosis,Bicuspid Aortic Valve}, url = {https://arya.mui.ac.ir/article_10474.html}, eprint = {https://arya.mui.ac.ir/article_10474_af314cdb7a906e43a4dd8461dd4573eb.pdf} } @article { author = {Azari, Ali and Bigdelu, Leila and Moravvej, Zahra}, title = {Surgical embolectomy in the management of massive and sub-massive pulmonary embolism: The results of 30 consecutive ill patients}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {208-213}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {BACKGROUND: Despite the improvement in the diagnosis and treatment of acute pulmonary embolism, it is yet a common clinical problem. The actual role of open embolectomy has not been well understood. The present report aimed to extrapolate the outcome of early open pulmonary embolectomy in a number of patients with acute (sub) massive pulmonary embolism (AMPE/ASMPE). METHODS: A prospective study was performed on 30 patients who underwent emergency embolectomy at Ghaem Hospital, Mashhad, Iran during January 2005 to November 2012. All patients with an indication for pulmonary embolectomy according to recent American Heart Association guideline were enrolled in this study. Echocardiographic features, pulmonary artery pressure, and right ventricular (RV) diameter were recorded. The patients were followed up monthly by two cardiologists. RESULTS: Indications for operation in descending order consisted of contraindication for fibrinolytic therapy (30%), failure to respond to fibrinolysis (26.66%), cardiopulmonary arrest (20%), patent foramen ovale (20%), right atrium clot (10%), and cardiogenic shock (10%). Mean pulmonary artery pressures were 52.26 ± 6.54 and 29.43 ± 2.87 mmHg before and after the operation, respectively (P < 0.0001). RV function and diameter improved significantly after surgery (P < 0.0001 and < 0.0001, respectively). Complete follow-up was performed in all surviving patients. All patients survived the operation, except one who died 2 days after surgery due to profound hypotension. CONCLUSION: Short and long-term outcomes of early open embolectomy seemed to be satisfactory in high-risk patients presenting high clot burden in central pulmonary arteries. This study demonstrated that pulmonary embolectomy may play a promising role in the management of AMPE and ASMPE and recommended for future clinical trials. }, keywords = {Echocardiography,Fibrinolysis,Embolectomy,Thromboembolism,Pulmonary,Treatment Outcome}, url = {https://arya.mui.ac.ir/article_10475.html}, eprint = {https://arya.mui.ac.ir/article_10475_74cd8f69e09adc9ce9220720c4ceabe7.pdf} } @article { author = {Journal, Index}, title = {Journal Index}, journal = {ARYA Atherosclerosis Journal}, volume = {11}, number = {3}, pages = {-}, year = {2015}, publisher = {Cardiovascular research institute, Isfahan University of Medical Sciences}, issn = {1735-3955}, eissn = {2251-6638}, doi = {}, abstract = {Click to download the index of this issue.}, keywords = {}, url = {https://arya.mui.ac.ir/article_10467.html}, eprint = {https://arya.mui.ac.ir/article_10467_8b748fcd34a7b90584591d24d1530fdd.pdf} }