EFFECT OF AN ANTI-INFLAMMATORY DRUG (PIROXICAM) ON SOME BIOCHEMICAL FACTORS AND DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS
Sedigheh
Asgary
Associate Professor (Ph.D), Isfahan Cardiovascular Research Center a WHO Collaborating Center For Research And Training In Cardiovascular Diseases Control, Prevention For Cardiac Patients in EMRO
author
Gholam-Ali
Naderi
Ph.D(2),
author
Gholam-Reza
Dashti
Ph.D(3),
author
Zamzam
Paknahad
Ph.D
author
text
article
2010
eng
ABSTRACT Objective: To investigate the effect of an anti-inflammatory drug (Piroxicam) on the development of fatty streak in rabbits. Methods: Male rabbits were fed with four types of regimen: a) normal rabbit chow, b) 1% cholesterol diet c) cholesterol diet plus Piroxicam, d) normal rabbit chow plus Piroxicam. After 12 weeks, the animals were sacrificed and the aorta, as well as the right and left branches of the coronary artery were dissected, and histological processing was carried out. Samples were observed under light microscope with different magnifications. Some biochemical tests were measured before and after the treatment. Results: A significant difference was found between the two groups receiving Piroxicam-supplemented diet and the two others (p<0.05) in respect of the mean grade of fatty streaks in the right and left coronary arteries, however, progression of the lesion in aorta was not statistically significant. Conclusion: Piroxicam was found to reduce C-reactive protein (CRP), triglyceride (TG) and LDL-C; it also led to an increase in antioxidant capacity and HDL-C. It is suggested that the anti-inflammatory drug, Piroxicam, has beneficial effects in preventing the development of fatty streaks. Key words: Fatty streak, piroxicam, rabbit, inflammation.
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10190_19b51011bf98391d92121f50fa4b8c00.pdf
CACAO TO COCOA TO CHOCOLATE: HEALTHY FOOD?
ROYA
KELISHADI
Associte Professor of Pediatrics, Head of Preventive Pediatric Cardiology Department, Isfahan Cardiovascular Research Center.
author
text
article
2010
eng
ABSTRACT Chocolate is derived from cocoa beans - the fruit of the cacao tree or Theobroma cacao (the latin term: food of the gods). Recent published articles demonstrate that the quality and quantity of the antioxidants in cocoa and chocolate are very high and their flavonoids are believed to reduce the number of free radicals in the body that contribute to medical problems, such as cardiovascular disease and cancer and also to offer some anti-aging health benefits. Cocoa can lower the leukotriene/ prostacyclin ratio and is shown to have beneficial effects on platelets and possibly inflammation and vessel dilation. They inhibit low-density lipoprotein (LDL) oxidation, raise the high-density lipoprotein (HDL) level and reduce the thrombotic tendency. Their antioxidant catechin content is four times that of tea. They help the body process nitric oxide. Their flavanols and procyanidins have inhibitory effects on hemolysis, they can also attribute as a defense against reactive oxygen species (ROS) and can inhibit their carcinogenic processes. Also they are shown to inhibit growth and polyamine biosynthesis of human colonic cancer cells. They contain tryptophan and anandamide, which lessen anxiety, promote relaxation and trigger the production of endorphins. Cocoa can prevent dental caries and may play a regulating role in the function of the immune system and prevent infectious and autoimmune diseases. It stimulates lactase enzyme activity. Although caffeine may be harmful in large dose, chocolate contains it in small amount in comparison to coffee and tea. Negative effects of chocolate on childhood hyperactivity and migraine as well as tension headaches are controversial. Since the theobromine content of chocolate relaxes the esophageal sphincter, patients suffering from heartburn should avoid it. Cocoa can trigger some allergic reactions such as atopic dermatitis. This article reviews the potential health benefits and disadvantages of cocoa & chocolate and suggests that their flavonoid-rich types are health beneficial and when consumed in moderation, along with other plant foods, can be part of a healthy diet. Keywords: Cacao, Cocoa, Chocolate, Antioxidants, Flavanols, Caffeine
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10191_91e4c9aee9c8617e03e1b7ce96003bb8.pdf
IS COMMON CAROTID INTIMA MEDIA THICKNESS AN INDEPENDENT PREDICTOR FOR CORONARY ARTERY DISEASE
Masoume
Sadeghi
Assistant Professor of Cardiology, Isfahan Cardiovascular Research Center
author
Hamidreza
Roohafza
MD ,
author
Masoud
Poormoghadas
MD3,
author
Aliakbar
Tavasoli
MD4,
author
Ramin
Heidari
MD5.
author
text
article
2010
eng
ABSTRACT Introduction: Non-invasive measurement of carotid intima media thickness (IMT) has been noted as a marker for atherosclerosis and can serve as a predictor of cardiovascular accidents. The present study investigates the relationship between carotid IMT and coronary artery disease (CAD). Method: This is a descriptive, analytical cross-sectional study of 300 individuals referring to Isfahan Cardiovascular Research Center (ICRC). After history taking, clinical examinations, and recording body weight and height, the subjects' lipid profile and fasting blood sugar (FBS) were evaluated. The subjects were divided into two groups according to CAD risk factors. The two groups were adjusted based on coronary disease risk factors. Maximum common carotid IMT was measured via B-mode ultrasonography in all subjects. Those with atherosclerotic plaques were excluded from the study. Collected data were statistically analyzed by SPSS10. Results: 65% of the subjects were male and 35% were female. They had a mean age of 50.72 years. 130 subjects (43%) were placed in the CAD group and 170 (56.7%) in the non-CAD group. There was no significant difference between the two groups in respect of risk factors such as age, total cholesterol, cigarette smoking, body mass index (BMI), hypertension, HDL-C, and LDL-C. Common carotid IMT was evaluated in the two groups. IMT that of the CAD group was found to be 0.8 millimeters more than that of the non-CAD group, which represents a statistically significant difference. Discussion: Different studies have shown varying relationships between carotid IMT and CAD. Based on the results of this study and in view of the safety and simplicity of ultrasonographic carotid IMT measurement, IMT can be used as a predictor of atherosclerosis in coronary arteries. Keywords: Intima-media, Carotid, Coronary Artery Disease (CAD), Ultrasonography
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10192_d116c672248252dbc45760ad4cae860f.pdf
TWO-YEAR INCIDENCE OF ACUTE FATAL AND NON-FATAL CORONARY ACCIDENT AND STROKE IN THE OVER-35 POPULATION IN CENTRAL IRAN
Babak
Sabet
Phycision General of Isfahan Cardiovascular Research Center
author
Roya
Derakhshan
General Physician
author
Masomeh
Sadeghi
Assistant Professor of Cardiology, Isfahan Cardiovascular Research Center.
author
Nizal
Sarraf –Zadegan
Professor of Cardiology, Isfahan Cardiovascular Resarch Center.
author
Fateme
Derakhshan
Medical Student.
author
Shidokhte
Hoseinee
Assistant Research of, Isfahan Cardiovascular Research Center.
author
SHamid
Rohafza
Assistant Professor of Psychiatry, Isfahan Cardiovascular Research Center.
author
Ahmad
Amani
MD,
author
Mohammad
Milani
MD.
author
text
article
2010
eng
ABSTRACT Introduction: Cardiovascular diseases and stroke constitute an important cause of death in most developed and undeveloped countries. Identification of the principal risk factors of coronary accidents and stroke and understanding of the relative risk posed by each of these risk factors are crucial to control and reduction of risk factors. Methods: 6542 individuals aged over 35 years from the cities of Isfahan, Arak and Najafabad were studied and followed for two years. The individuals were chosen from among the population of 12800 people, selected in several stages to participate in Isfahan Healthy Heart Program (IHHP). Pregnant women, mentally retarded individuals, and those with hemorrhagic diseases were excluded from the study. Risk factors were extracted based on definition using SPSS11 software, and the degree of risk posed by each risk factor was determined. Results: The incidence of acute coronary accidents was studied in 3970 (60.7%) healthy individuals participating in IHHP, who were followed over a period of two years. 60 deaths (1.5% of the population) occurred during the two years, 1% of which were caused by myocardial infarction (MI). There were 115 instances of fatal and non-fatal cardiac accidents (2.9% of the population). Strokes were seen in half of the cases. A positive history of smoking was accompanied by reduced survival of subjects in this study. The incidence of non-fatal cardiac accidents also increased with diastolic hypertension and triglyceride level. In this study, the greatest risk of cardiac accidents was associated with hypertension, diabetes, metabolic syndrome, and positive history of smoking. Discussion: In this study, the two-year incidence of cardiac accidents was higher than that of Ewopean countris. The relative risk of risk factors such as diabetes, positive history of smoking, and hypertension was also notably higher than that of similar studies. In light of the higher risk of cardiac accidents compared with similar studies, preparing a risk chart based on geographical and cultural features for evaluation of the risk of cardiac accidents seems imperative. Key Words: Risk chart, Fatal cardiac accidents, Non-fatal cardiac accidents, stroke, Cardiovascular risk factors, Iran
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10193_c65a75acab61b62c1bc00be4678d733e.pdf
EVALUATION OF LIPID PROFILE IN PATIENT WITH MAJOR DEPRESSIVE DISORDER AND GENERALIZED ANXIETY DISORDER
Hamidreza
Roohafza
MD,
author
Masoumeh
Sadeghi
MD,
author
Hamid
Afshar
MD,
author
Ghafor
Mousavi
MD,
author
Shahin
Shirani
MD.
author
text
article
2010
eng
ABSTRACT Introduction: Several studies demonstrated association between dislipidemia and psychiatric disorder. The aim of this study is evaluation of the lipid profile of patient with comorbid generalized anxiety disorder and major depressive disorder. Method: This is a descriptive- analytic study of 100 patient (25 in major depressive disorder, 25 in generalized anxiety disorder, 25 in comorbid anxiety and depressive disorder and 25 control subjects according to DSM-IV). Then demographic detail was filled and blood sampling for lipid profile was drowns. Beck and Kattle inventory was completed. Data were analyzed by chi-square, t-test and ANOVA. Results: Seventy-five % of patient was female. Total cholesterol, triglyceride and low-density lipoprotein cholesterol levels are significantly higher and high-density lipoprotein cholesterol level is lower in patient with comorbid anxiety and depressive disorder other groups. Discussion: According to our result, dislipdemia of comorbid anxiety and depressive disorder was considerable and lipid detection in this patient for precise prevention of atherosclerosis in first phase recommended to reduce prevalence of cardiovascular disease in these patients. Keywords: Lipid profile, Generalized anxiety disorder, Major depressive disorder,
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10194_8b25fa2efb653e2afc242db450bcd430.pdf
BLOOD PRESSURE LEVELS AND TRENDS OF OBESITY IN HYPERTENSIVE PATIENTS VERSUS HEALTH INDIVIDUALS: ISFAHAN 1991-2001
Alireza
Khosravi
Cardiologist. Chief of High Blood
Pressure Research Unit, Isfahan Cardiovascular Research
Center, Isfahan.
author
Rezvan
Ansari
author
Shahin
Shirani
MD
author
text
article
2010
eng
ABSTRACT Introduction: Obesity is an independent risk factor for cardiovascular disease. Several clinical studies have shown that blood pressure decreases significantly with reduction of body weight. The aim of this study was to assess the trend of hypertension and obesity according to body mass index in three descriptive cross-sectional studies conducted in the city of Isfahan during a period of ten years. Methods: This study consisted of three cross-sectional surveys conducted among the population of over-25 individuals in Isfahan. Sampling was performed with the random clustering method. The blood pressure of subjects was checked twice, one week apart. Blood pressure measurement was conducted by an experienced nurse. Raw data was statistically analyzed with SPSS10, with t-test and ANOVA. Results: During 3 surveys conducted in 1991-1992, 1995-1996, and 2000-2001 in the over-25 population in Isfahan, 2438, 3234, and 2015 individuals were studied, respectively. Mean systolic blood pressure (SBP) decreased significantly in all groups (P<0.005). However, decrease in (DBP) was significant only in men and women who were under treatment with antihypertensive drugs (P<0.05). In all hypertensive groups under study and in health subjects, there was an increase in body mass index (BMI). This increase had a more notable trend in hypertensive groups, compared with healthy individuals. The prevalence of obesity in hypertensive patients was higher than that of the healthy group during the ten years of the study. Discussion: Obesity has had a rising prevalence during the last ten years in hypertensive and healthy individuals. In light of the importance of weight control in hypertensive patients, it is recommendable as a primary prevention measure. Keywords: Trend, Hypertension, Obesity, Isfahan
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10195_3ea1780c76f9899821485c67ac11470a.pdf
STUDY OF SMOKING PREVALENCE AND RELATIVE FACTORS ON RESIDENT MEN IN ISFAHAN 2002
N
Bashardoost
Associate Professor pf Biostatistics, Epidemiology department of Health School of Isfahan Medicine University
author
R
Tavakoli Grmashe
MS,
author
M
Kianpoor
BS
author
text
article
2010
eng
Abstract Introduction: Smoking is one of the sanitary problems in world today. Increasing smoking of cigarette and other tobacco products has concerned health managers and community responsible. In recent decades, smoking has increased specially in developing countries and the smokers are adding every year. The objective of this study is determination of smoking prevalence and its distribution by a few of cases characteristics. Method: This is cross-sectional study that has done on men with at least 15 years old in Isfahan. Data was collected by a questionnaire at homes on summer, 2002.The samples were 1600 and the variables included: age, marriage status, level of education, job, smoking status(king and quanta),age of beginning to smoke and precedence of smoking. Results: Results showed that 21.5% individuals were smoking cigarette 10.4%hooka and 1.5 pipe. The age of beginning to smoke cigarette was <20 years in 67.6% of cases. Smoking was more prevalent in adults. Workers with 32.7% were smoking more and students with 5% and scholars with 6.7% were smoking less than others. Smoking was relative to level of education and marriage men smoked 2.5 times more than singles Discussion: The results showed that in comparison with other areas in Iran, Isfahan men are smoking further especially for hooka and pipe. Also it has become a new problem that the younger smoke hooka and pipe more than past, because the people thinks that those are less harmful that cigarette. Keyword: Prevalence, Cigarette, Hooka, Pipe and Isfahan
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10196_830e07cd8737acd8439fc4b213dc51e0.pdf
ANGIOPLASTY AND STENTING OF BASILAR ARTERY WITH SHORT-TERM RESULTS
Massoud
Ghasemi
Invasive Cardiology Department, Sasan General Hospital, Tehran.
author
Hashemi
Fesharaki
Neurology Department, Sasan General Hospital, Tehran, Iran.
author
Mehdi
Sanatkar
Research Center of Endovascular Intervention, Tehran, Iran.
author
text
article
2010
eng
ABSTRACT Symptomatic basilar artery stenosis has a poor prognosis. Surgical bypasses are technically demanding and of no proven benefit. A new generation of intravascular stents that are flexible enough to navigate the tortuosities of the vertebral artery may provide a new therapeutic approach. Our two cases, 57 and 52 year-old men experienced a vertebrobasilar ischemia with repeated vertigo and falls. Magnetic resonance angiography from vertebrobasilar arteries revealed severe middle basilar artery stenos is in one case, and severe vertebrobasilar artery stenosis in the other. The patients underwent uncomplicated angioplasty and stenting of the basilar arteries, with excellent angiographic results. The new flexible intravascular stents provide a new therapeutic approach for patients with basilar artery stenosis. Key Words: Basilar artery - Vertebral artery – Angioplasty – Stenting
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10197_b40c0c6bc03e6cf3c675bbd9016391e9.pdf
An abridged guideline for Acute Stroke Management
Shahram
Oveisgharan
Neurology Department;
Shariati Hospital; Tehran University of Medical
Sciences; Tehran.
author
Akbar
Soltanzadeh
Professor of Neurology, Neurology Department; Shariati Hospital; Tehran University of Medical Sciences; Tehran; Iran.
author
Askar
Ghorbani
Assistant Professor of Neurology, Neurology Department; Shariati Hospital; Tehran University of Medical Sciences; Tehran; Iran.
author
text
article
2010
eng
Stroke is one of the most prevalent and disabling disease in human being. Approximately 700000 strokes occur each year in the United States, leaving 500 000 stroke survivors with disability, and economic loss resulting from stroke approaches an estimated $51.2 billion annually 1. What comes below is stroke management guideline used at Massachusetts General Hospital (at Harvard medical school) in year 2005 2. This presentation is an abridged form of the proposed guideline. At the end, some comments and recommendations are presented regarding acute stroke management in Iran.
ARYA Atherosclerosis Journal
Cardiovascular research institute, Isfahan University of Medical Sciences
1735-3955
1
v.
1
no.
2010
https://arya.mui.ac.ir/article_10198_75c57755d250d219a67f61ad880558dd.pdf