:1698 (15 March 2021) DOI:10.22122/arya.v17i0.1698

The effect of educational and encouraging interventions on anthropometric characteristics and perilipin-1 levels: TABASSOM Study

Maryam Maghroun, Noushin Mohammadifard, Firoozeh Sajjadi, Narges Jafaridinani, Simin Karimi, Katayoun Rabiei, Soraya Massoudi, Nizal Sarrafzadegan

DOI: http://dx.doi.org/10.22122/arya.v17i0.1698


BACKGROUND: Perilipin protein located in lipid droplets is involved in formation and storage of lipid in adipocytes; thus, it is considered as one of the obesity biomarkers. This study was performed to examine the effect of educational and encouragement interventions and lifestyle modifications on anthropometric characteristics and perilipin-1 level.

METHODS: This quasi-experimental study was conducted on subsample of TABASSOM Study. Participants were 42 overweight and obese children and adolescents aged 6-18 years old and 80 overweight and obese adults aged 19-65 years old. Anthropometric characteristics including weight, height, waist circumference (WC), body fat percentage (BFP), and perilipin-1 level were measured at the first and the end of study (after one year).

RESULTS: After intervention, the mean of perilipin-1 decreased significantly in total children and adolescents (before vs. after: 26.79 ± 13.17 vs. 22.57 ± 8.03; P = 0.006) and girls (27.75 ± 10.51 vs. 22.00 ± 8.15; P = 0.001), but decreasing was not significant in boys. In adults, perilipin-1 levels were significantly reduced in total subjects (before vs. after: 16.19 ± 13.42 vs. 15.34 ± 11.25; P = 0.029) and men (18.02 ± 15.78 vs. 15.44 ± 10.61; P = 0.003). There was no significant difference in mean of body mass index (BMI), WC, and BFP in both groups after 12 months.

CONCLUSION: Educational and encouraging interventions and lifestyle modifications could lead to decreasing perilipin-1 level in adults, children, and adolescents.



Obesity; Overweight; Adult; Child; Adolescent; Perilipin-1; Anthropometry

Full Text:



Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight:

A systematic review and meta-analysis. BMC Public Health 2009; 9: 88.

World Health Organization. Commission on ending childhood obesity [Online]. [cited 2017]; Available from: URL: https://www.who.int/end-childhood-obesity/en

Sarrafzadegan N, Kelishadi R, Sadri G, Malekafzali H, Pourmoghaddas M, Heidari K, et al. Outcomes of a comprehensive healthy lifestyle program on cardiometabolic risk factors in a developing country: The Isfahan Healthy Heart Program. Arch Iran Med 2013; 16(1): 4-11.

Manolio TA, Bailey-Wilson JE, Collins FS. Genes, environment and the value of prospective cohort studies. Nat Rev Genet 2006; 7(10): 812-20.

Ordovas JM, Smith CE. PLIN1 gene: Fat keeper and prevention switcher. J Appl Physiol (1985) 2010; 108(3): 477-8.

Tai ES, Ordovas JM. The role of perilipin in human obesity and insulin resistance. Curr Opin Lipidol 2007; 18(2): 152-6.

Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem 1991; 266(17): 11341-6.

Lee MJ, Fried SK. Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion. Am J Physiol Endocrinol Metab 2009; 296(6): E1230-E1238.

Abete I, Parra D, Martinez JA. Legume-, fish-, or high-protein-based hypocaloric diets: Effects on weight loss and mitochondrial oxidation in obese men. J Med Food 2009; 12(1): 100-8.

Meier U, Gressner AM. Endocrine regulation of energy metabolism: Review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004; 50(9): 1511-25.

Zou CC, Liang L, Wang CL, Fu JF, Zhao ZY. The change in ghrelin and obestatin levels in obese children after weight reduction. Acta Paediatr 2009; 98(1): 159-65.

MacLean PS, Higgins JA, Jackman MR, Johnson GC, Fleming-Elder BK, Wyatt HR, et al. Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol 2006; 290(6): R1577-R1588.

Crujeiras AB, Goyenechea E, Abete I, Lage M, Carreira MC, Martinez JA, et al. Weight regain after a diet-induced loss is predicted by higher baseline leptin and lower ghrelin plasma levels. J Clin Endocrinol Metab 2010; 95(11): 5037-44.

Gao Y, Griffiths S, Chan EY. Community-based interventions to reduce overweight and obesity in China: A systematic review of the Chinese and English literature. J Public Health (Oxf) 2008; 30(4): 436-48.

Tehrani M, Baji Z, Shakerinejad G, Hajinajaf S, Jarvandi F, Saki M. Effects of nutrition education on anthropometric indices, biochemical and sonographic findings of patients with non-alcoholic fatty liver disease (NAFLD). Iran J Health Educ Health Promot 2017; 5(1): 33-42.

Golshiri P, Yarmohammadi P, Sarrafzadegan N, Shahrokhi S, Yazdani M, Pourmoghaddas M. Developing and validating questionnaires to assess knowledge, attitude, and performance toward obesity among Iranian adults and adolescents: TABASSOM study. ARYA Atheroscler 2012; 7(Suppl): S119-S124.

Abolhassani S, Irani MD, Sarrafzadegan N, Rabiei K, Shahrokhi S, Pourmoghaddas Z, et al. Barriers and facilitators of weight management in overweight and obese people: Qualitative findings of TABASSOM project. Iran J Nurs Midwifery Res 2012; 17(3): 205-10.

Goodpaster BH, Delany JP, Otto AD, Kuller L, Vockley J, South-Paul JE, et al. Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial. JAMA 2010; 304(16): 1795-802.

Reinehr T, de Sousa G, Toschke AM, Andler W. Long-term follow-up of cardiovascular disease risk factors in children after an obesity intervention. Am J Clin Nutr 2006; 84(3): 490-6.

Kelishadi R, Mohammadifard N, Sarrazadegan N, Nouri F, Pashmi R, Bahonar A, et al. The effects of a comprehensive community trial on cardiometabolic risk factors in adolescents: Isfahan Healthy Heart Program. ARYA Atheroscler 2012; 7(4): 184-90.

Sahota P, Rudolf MC, Dixey R, Hill AJ, Barth JH, Cade J. Randomised controlled trial of primary school based intervention to reduce risk factors for obesity. BMJ 2001; 323(7320): 1029-32.

Levin BE. The drive to regain is mainly in the brain. Am J Physiol Regul Integr Comp Physiol 2004; 287(6): R1297-R1300.

Seoane LM, Al-Massadi O, Caminos JE, Tovar SA, Dieguez C, Casanueva FF. Sensory stimuli directly acting at the central nervous system regulate gastric ghrelin secretion. An ex vivo organ culture study. Endocrinology 2007; 148(8): 3998-4006.

Qi L, Corella D, Sorli JV, Portoles O, Shen H, Coltell O, et al. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Clin Genet 2004; 66(4): 299-310.

Kern PA, Di Gregorio G, Lu T, Rassouli N,

Ranganathan G. Perilipin expression in human adipose tissue is elevated with obesity. J Clin Endocrinol Metab 2004; 89(3): 1352-8.

Soenen S, Mariman EC, Vogels N, Bouwman FG, den Hoed M, Brown L, et al. Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance. Physiol Behav 2009; 96(4-5): 723-8.

Corella D, Qi L, Sorli JV, Godoy D, Portoles O, Coltell O, et al. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. J Clin Endocrinol Metab 2005; 90(9): 5121-6.

Corella D, Qi L, Tai ES, Deurenberg-Yap M, Tan CE, Chew SK, et al. Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care 2006; 29(6): 1313-9.

Pasdar Y, Moridi S, Najafi F, Niazi P, Heydari M. The effect of nutritional intervention and physical activities on weight reduction. J Kermanshah Univ Med Sci 2012; 15(6): 427-34. [In Persian].


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 4.0

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.