Document Type : Original Article
Authors
- Mohammadtaghi Sarebanhassanabadi 1
- Mahdieh Mousavirad 2
- Lida Hosseini 3
- Pedro Marques-Vidal 4
- Alexander Kraemer 5
- Seyedeh Mahdieh Namayandeh 6
- Hamideh Mihanpour 1
- Sima Mozafari 1
1 Yazd Cardiovascular Research Center, Non-communicable diseases research institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2 Department of Physical Medicine & Rehabilitation, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran
4 Department of Internal Medicine, BH10-642, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland
5 Department of Health Sciences, Bielefeld University, Bielefeld, Germany
6 Afshar Clinical Research Development Center, Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
Introduction: The incidence of coronary artery disease (CAD) is influenced by several risk factors including hypertension. Although the association between hypertension and CAD has been investigated in Western countries, limited research has been conducted in Asia and the Middle East. We investigated the association between hypertension and the 10-year risk of CAD in the adult population.
Method: In this cohort study, 2000 participants aged 20 to 74 years in the Yazd Healthy Heart Project were registered in 2005-2006 and followed up to 2015-2016. Participants with a history of CAD were excluded from the study. At baseline, we collected data on demographic characteristics, anthropometric measurements, biochemical blood tests, and lifestyle. Finally, the association between hypertension and approximately 10-year CAD risk was assessed using the Cox regression model.
Results: Our analysis showed that the baseline prevalence of hypertension among adults was 36.1%. Throughout the ten-year follow-up, CAD incidence was recorded at 16.8% for male, 12.0% for female, and 14.5% for total population. After adjusting for potential confounders, hypertension increased the risk of CAD in male (HR = 1.64, 95% CI: 1.09-2.46); female (HR = 2.16, 95% CI: 1.15-4.05) and the whole sample (HR = 1.73, 95% CI: 1.23-2.43). This association was similar in male and female (P for interaction ≥ 0.05).
Conclusion: This study showed a significant association between hypertension and CAD risk, highlighting the need for targeted interventions in populations with hypertension to reduce CAD risk.
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