Document Type : Original Article
Authors
- Mohammadtaghi Sarebanhassanabadi 1
- mahnaz eider 1
- Hamideh Mihanpour 2
- Pedro Marques-Vidal 3
- Seyed Jalil Mirhosseini 4
- Lida Hosseini 4
- Seyedeh Mahdieh Namayandeh 4
- sima mozafari 4
1 Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Occupational Health Engineering, Genetic and Environmental Adventures Research Center, school of Abarkouh Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Department of Internal Medicine, BH10-642, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland
4 Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
Background: Hypertriglyceridemic waist phenotype (HTGW), a surrogate indicator of visceral adiposity, has been proposed as a simple screening tool for cardiometabolic risk. Limited information is available on the influence of HTGW and its temporal variations on the development of hypertension. The current study examined the association between HTGW and a decade-long hypertension incidence in an urban population of Iranian adults.
Methods: This study utilized data from the Yazd Healthy Heart Project (YHHP). In its initial phase (2005-2006), 2000 participants aged 20-74 years were enrolled. At this baseline visit, demographic characteristics, blood pressure, anthropometric data, and biochemical tests were evaluated and reassessed in 2015–2016. After excluding individuals with hypertension at baseline, 1,269 normotensive participants were followed for approximately 10-year to assess incident hypertension, using multivariable logistic regression analyses in SPSS.
Results: In this study, after excluding participants lost to follow-up, 786 participants were selected for the final analysis. The cumulative incidence of hypertension was 40.3% (317 out of 786). After adjustment for potential confounders, the risk of HTN was significantly higher among participants with hypertriglyceridemia (OR=2.38, 95%CI: 1.21-4.67) and those with HTGW (OR=1.88, 95%CI: 1.12-3.13) compared to those with normal waist and normal triglycerides (NWNT) in the total population. Also, in men, there was a positive significant association between hypertriglyceridemia (OR=2.71, 95%CI: 1.22-6.02) and HTGW (OR=2.35, 95%CI: 1.23-4.47) and 10-year incidence of HTN after multivariate adjustment.
Conclusion: Our findings showed that hypertriglyceridemia and HTGW are independent predictors of 10-year hypertension incidence, particularly among men, in an Iranian urban adult population.
Keywords
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