Document Type : Original Article

Authors

• Mahdiyeh Yaghooti-Khorasani ^{1, 2}
• Naiemeh Varasteh ²
• Hossein Hatamzadeh ³
• Sara Saffar Soflaei ^{1, 2}
• Susan Darroudi ²
• Toktam Sahranavard ²
• Maryam Allahyari ³
• Ehsan Mosa Farkhani ⁴
• Alireza Heidari-Bakavoli ^{5, 6}
• Hedieh Alimi ⁵
• Azadeh Izadi-Moud ⁷
• Fahime Hosseinzadeh ^{8, 9}
• Gordon A. Ferns ¹⁰
• Habibollah Esmaily ^{8, 9}
• Majid Ghayour-Mobarhan ^{1, 2}
• Mohsen Moohebati ^{5, 6}

¹ Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

² International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

³ Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

⁴ Department of Epidemiology, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran

⁵ Vascular and Endovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

⁶ Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

⁷ Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

⁸ Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran

⁹ Social Determinants of Health Research center, Mashhad University of Medical Sciences, Mashhad, Iran

¹⁰ Brighton and Sussex Medical School, Division of Medical Education, Brighton, UK

Abstract

BACKGROUND: Finding the relation between complete blood count (CBC) parameters and ischemic electrocardiogram (ECG) changes among a large normal population, for the first time.
METHODS: Participants of the first phase of the MASHAD cohort study were enrolled in this cross-sectional study. Twelve-lead ECGs were taken from participants. According to the Minnesota codes, we divided the ischemic ECG changes into major and minor. Major ischemic changes included major Q-wave changes, minor Q-wave plus ST-T changes, and major isolated ST-T changes. Minor changes included minor isolated Q/QS waves, minor ST/T changes, and ST-segment elevation. The mean of the CBC parameters was compared between individuals with and without ischemic changes. The backward stepwise logistic regression model was implemented to estimate the odds ratios of ECG changes and eliminate confounders. Data were analyzed using SPSS version 20, with significance set at p < 0.05.
RESULTS: Among 9,106 participants, 510 individuals (5.6%) had minor and major ischemic changes, with a preference for males. Major ischemic changes were not associated with CBC parameters. However, the odds of having minor ischemic changes increased 1.96-fold with increasing red blood cell (RBC) count (OR = 1.96 [1.31–2.94], p = 0.001); though, they decreased by 0.18 units with increasing hemoglobin (OR = 0.81 [0.73–0.92], p = 0.001). Additionally, high mean corpuscular volume (MCV) increased the odds of minor ischemic changes (OR = 1.05 [1.01–1.08], p = 0.004).
CONCLUSION: Among Mashhad’s normal population, major ischemic changes were not associated with CBC parameters. Also, minor and major ischemic changes were positively associated with WBC count.

Keywords

• Electrocardiogram
• Complete Blood Count
• Cardiovascular Disease